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Aliases for TLR8 Gene

Aliases for TLR8 Gene

  • Toll-Like Receptor 8 2 3
  • CD288 Antigen 4
  • CD288 3

External Ids for TLR8 Gene

Previous GeneCards Identifiers for TLR8 Gene

  • GC0XP012117
  • GC0XP011690
  • GC0XP012221
  • GC0XP012286
  • GC0XP012684
  • GC0XP012834
  • GC0XP010691

Summaries for TLR8 Gene

Entrez Gene Summary for TLR8 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR8 Gene

TLR8 (Toll-Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include crimean-congo hemorrhagic fever and hemorrhagic fever. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include RNA binding and double-stranded RNA binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR8 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Wiki entry for TLR8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR8 Gene

Genomics for TLR8 Gene

Regulatory Elements for TLR8 Gene

Genomic Location for TLR8 Gene

Start:
12,906,620 bp from pter
End:
12,923,171 bp from pter
Size:
16,552 bases
Orientation:
Plus strand

Genomic View for TLR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR8 Gene

Proteins for TLR8 Gene

  • Protein details for TLR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR97-TLR8_HUMAN
    Recommended name:
    Toll-like receptor 8
    Protein Accession:
    Q9NR97
    Secondary Accessions:
    • B3Y654
    • D1CS70
    • D1CS76
    • Q495P4
    • Q6UXL6
    • Q9NYG9

    Protein attributes for TLR8 Gene

    Size:
    1041 amino acids
    Molecular mass:
    119828 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK.

    Three dimensional structures from OCA and Proteopedia for TLR8 Gene

    Alternative splice isoforms for TLR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR8 Gene

Proteomics data for TLR8 Gene at MOPED

Post-translational modifications for TLR8 Gene

  • Glycosylation at Asn29, Asn42, Asn80, Asn88, Asn115, Asn160, Asn247, Asn285, Asn293, Asn358, Asn362, Asn395, Asn416, Asn443, Asn511, Asn546, Asn582, Asn590, Asn640, Asn680, and Asn752
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR8 Gene

Domains for TLR8 Gene

Gene Families for TLR8 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Suggested Antigen Peptide Sequences for TLR8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR97

UniProtKB/Swiss-Prot:

TLR8_HUMAN :
  • Q9NR97
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 23 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR8: view

Function for TLR8 Gene

Molecular function for TLR8 Gene

UniProtKB/Swiss-Prot Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Ontology (GO) - Molecular Function for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16123302
GO:0003723 RNA binding TAS 16123302
GO:0003725 double-stranded RNA binding IDA 16111635
GO:0003727 single-stranded RNA binding IDA 14976262
GO:0004872 receptor activity NAS 12032557
genes like me logo Genes that share ontologies with TLR8: view
genes like me logo Genes that share phenotypes with TLR8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TLR8 Gene

Localization for TLR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR8 Gene COMPARTMENTS Subcellular localization image for TLR8 gene
Compartment Confidence
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
lysosome 4
vacuole 4
plasma membrane 3
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0010008 endosome membrane TAS --
GO:0016021 integral component of membrane IC 12032557
GO:0036020 endolysosome membrane TAS --
genes like me logo Genes that share ontologies with TLR8: view

Pathways for TLR8 Gene

genes like me logo Genes that share pathways with TLR8: view

Gene Ontology (GO) - Biological Process for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TLR8: view

Compounds for TLR8 Gene

(1) Drugbank Compounds for TLR8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Imiquimod
99011-02-6 target agonist

(2) IUPHAR Ligand for TLR8 Gene

Ligand Type Action Affinity Pubmed IDs
imiquimod Agonist Agonist
R848 Agonist Agonist

(4) Novoseek inferred chemical compound relationships for TLR8 Gene

Compound -log(P) Hits PubMed IDs
resiquimod 92.4 1
imidazoquinoline 89.2 6
imiquimod 75.5 5
poly(i-c) 59.7 1
genes like me logo Genes that share compounds with TLR8: view

Transcripts for TLR8 Gene

Unigene Clusters for TLR8 Gene

Toll-like receptor 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: - -
SP2: - - -
SP3:

Relevant External Links for TLR8 Gene

GeneLoc Exon Structure for
TLR8
ECgene alternative splicing isoforms for
TLR8

Expression for TLR8 Gene

mRNA expression in normal human tissues for TLR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR8 Gene

This gene is overexpressed in Whole Blood (43.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR8 Gene

SOURCE GeneReport for Unigene cluster for TLR8 Gene Hs.660543

mRNA Expression by UniProt/SwissProt for TLR8 Gene

Q9NR97-TLR8_HUMAN
Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells
genes like me logo Genes that share expressions with TLR8: view

Orthologs for TLR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR8 35
  • 99.42 (n)
  • 99.62 (a)
TLR8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLR8 35
  • 80.71 (n)
  • 74.93 (a)
dog
(Canis familiaris)
Mammalia TLR8 35
  • 80.66 (n)
  • 77.51 (a)
TLR8 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr8 35
  • 76.73 (n)
  • 71.84 (a)
Tlr8 16
Tlr8 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLR8 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr8 35
  • 76.49 (n)
  • 72 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495962 35
  • 58.96 (n)
  • 52.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332583 35
  • 51.7 (n)
  • 45.32 (a)
TLR8 (3 of 3) 36
  • 43 (a)
OneToMany
tlr8a 36
  • 42 (a)
OneToMany
tlr8b 36
  • 40 (a)
OneToMany
Species with no ortholog for TLR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR8 Gene

ENSEMBL:
Gene Tree for TLR8 (if available)
TreeFam:
Gene Tree for TLR8 (if available)

Paralogs for TLR8 Gene

Paralogs for TLR8 Gene

Selected SIMAP similar genes for TLR8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TLR8: view

Variants for TLR8 Gene

Sequence variations from dbSNP and Humsavar for TLR8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1013150 -- 12,914,322(+) TGGAA(A/G)ATCCT intron-variant
rs1013151 -- 12,914,412(+) cagaa(C/T)tctct intron-variant
rs1548731 -- 12,909,828(+) GTCTG(C/T)AAAGC intron-variant
rs2109134 -- 12,909,067(+) CCAGG(A/T)TCCAT intron-variant
rs2109135 -- 12,921,809(+) TGGGA(C/T)CCGGG reference, synonymous-codon

Relevant External Links for TLR8 Gene

HapMap Linkage Disequilibrium report
TLR8
Human Gene Mutation Database (HGMD)
TLR8
Locus Specific Mutation Databases (LSDB)
TLR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR8 Gene

Disorders for TLR8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TLR8 Gene including...

Search for TLR8 Gene in MalaCards »

(6) Novoseek inferred disease relationships for TLR8 Gene

Disease -log(P) Hits PubMed IDs
virus infection 46 4
inflammation 20.7 1
influenza 1.34 1
necrosis 0 2
tumors 0 5

Relevant External Links for TLR8

Genetic Association Database (GAD)
TLR8
Human Genome Epidemiology (HuGE) Navigator
TLR8
genes like me logo Genes that share disorders with TLR8: view

No data available for UniProtKB/Swiss-Prot for TLR8 Gene

Publications for TLR8 Gene

  1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X. … Beutler B. (Eur. Cytokine Netw. 2000) 2 3 4 23
  2. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng P.L. … Lin T.M. (Transl Res 2007) 3 23 48
  3. A functional toll-like receptor 8 variant is associated with HIV disease restriction. (PMID: 18605904) Oh D.Y. … Schumann R.R. (J. Infect. Dis. 2008) 3 23 48
  4. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. (PMID: 18927625) Davila S. … Seielstad M. (PLoS Genet. 2008) 3 23 48
  5. Toll-like receptor 8 polymorphism and coronary artery disease. (PMID: 18985439) Chen Z. … Tang C. (Mol. Biol. Rep. 2009) 3 23 48

Products for TLR8 Gene

  • Addgene plasmids for TLR8

Sources for TLR8 Gene

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