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Aliases for TLR7 Gene

Aliases for TLR7 Gene

  • Toll Like Receptor 7 2 3
  • Toll-Like Receptor 7 2 5
  • Toll-Like Receptor 7-Like 3
  • TLR7-Like 3

External Ids for TLR7 Gene

Previous GeneCards Identifiers for TLR7 Gene

  • GC0XP012078
  • GC0XP011651
  • GC0XP012181
  • GC0XP012246
  • GC0XP012644
  • GC0XP012795
  • GC0XP010651
  • GC0XP012885

Summaries for TLR7 Gene

Entrez Gene Summary for TLR7 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR7 Gene

TLR7 (Toll Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include superficial basal cell carcinoma and anogenital venereal wart. Among its related pathways are Immune System and p53 Pathway (RnD). GO annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR7 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tocris Summary for TLR7 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR7 Gene

Genomics for TLR7 Gene

Regulatory Elements for TLR7 Gene

Promoters for TLR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLR7 Gene

Chromosome:
X
Start:
12,867,083 bp from pter
End:
12,890,380 bp from pter
Size:
23,298 bases
Orientation:
Plus strand

Genomic View for TLR7 Gene

Genes around TLR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR7 Gene

Proteins for TLR7 Gene

  • Protein details for TLR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYK1-TLR7_HUMAN
    Recommended name:
    Toll-like receptor 7
    Protein Accession:
    Q9NYK1
    Secondary Accessions:
    • D1CS69
    • Q9NR98

    Protein attributes for TLR7 Gene

    Size:
    1049 amino acids
    Molecular mass:
    120922 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).

neXtProt entry for TLR7 Gene

Proteomics data for TLR7 Gene at MOPED

Post-translational modifications for TLR7 Gene

  • Glycosylation at Asn 66, Asn 69, Asn 167, Asn 202, Asn 215, Asn 361, Asn 413, Asn 488, Asn 523, Asn 534, Asn 590, Asn 679, Asn 720, and Asn 799
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR7 (TLR7)

No data available for DME Specific Peptides for TLR7 Gene

Domains & Families for TLR7 Gene

Gene Families for TLR7 Gene

Suggested Antigen Peptide Sequences for TLR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYK1

UniProtKB/Swiss-Prot:

TLR7_HUMAN :
  • Contains 1 TIR domain.
  • Belongs to the Toll-like receptor family.
  • Contains 27 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 27 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR7: view

Function for TLR7 Gene

Molecular function for TLR7 Gene

UniProtKB/Swiss-Prot Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
genes like me logo Genes that share phenotypes with TLR7: view

Animal Models for TLR7 Gene

MGI Knock Outs for TLR7:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLR7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR7 Gene

Localization for TLR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR7 Gene COMPARTMENTS Subcellular localization image for TLR7 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
cytosol 2
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19740627
GO:0005764 lysosome IEA,ISS --
GO:0005768 endosome IEA,ISS --
GO:0016021 integral component of membrane IEA --
GO:0032009 early phagosome IEA,ISS --
genes like me logo Genes that share ontologies with TLR7: view

Pathways & Interactions for TLR7 Gene

genes like me logo Genes that share pathways with TLR7: view

Gene Ontology (GO) - Biological Process for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002224 toll-like receptor signaling pathway IEA,TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA,IBA --
genes like me logo Genes that share ontologies with TLR7: view

No data available for SIGNOR curated interactions for TLR7 Gene

Drugs & Compounds for TLR7 Gene

(15) Drugs for TLR7 Gene - From: Novoseek, IUPHAR, DGIdb, Tocris, DrugBank, ApexBio, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist, agonist, Target TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 131
Hydroxychloroquine Approved Pharma inhibitor, antagonist, Target Autophagy inhibitor 136
ANA971 Investigational Pharma Target 0
Isatoribine Investigational Pharma Target 0
SCV-07 Investigational Pharma Target 0

(8) Additional Compounds for TLR7 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
R848
Agonist
Pam3CSK4
112208-00-1
Poly(I:C)
24939-03-5
RWJ 21757
121288-39-9
genes like me logo Genes that share compounds with TLR7: view

Drug Products

Transcripts for TLR7 Gene

mRNA/cDNA for TLR7 Gene

Unigene Clusters for TLR7 Gene

Toll-like receptor 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR7 Gene

No ASD Table

Relevant External Links for TLR7 Gene

GeneLoc Exon Structure for
TLR7
ECgene alternative splicing isoforms for
TLR7

Expression for TLR7 Gene

mRNA expression in normal human tissues for TLR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLR7 Gene

This gene is overexpressed in Testis (58.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR7 Gene



SOURCE GeneReport for Unigene cluster for TLR7 Gene Hs.659215

mRNA Expression by UniProt/SwissProt for TLR7 Gene

Q9NYK1-TLR7_HUMAN
Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
genes like me logo Genes that share expression patterns with TLR7: view

Protein tissue co-expression partners for TLR7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TLR7 Gene

Orthologs for TLR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLR7 35
  • 87.5 (n)
  • 86.55 (a)
TLR7 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR7 35
  • 86.91 (n)
  • 85.61 (a)
TLR7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr7 35
  • 83.16 (n)
  • 80.84 (a)
Tlr7 16
Tlr7 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLR7 35
  • 99.65 (n)
  • 99.52 (a)
TLR7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr7 35
  • 83.25 (n)
  • 80.65 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TLR7 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLR7 35
  • 67.25 (n)
  • 65.3 (a)
TLR7 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLR7 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr7 35
  • 63.44 (n)
  • 61.68 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr7 35
  • 58.39 (n)
  • 57.28 (a)
tlr7 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7896 37
  • 26 (a)
Species with no ortholog for TLR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR7 Gene

ENSEMBL:
Gene Tree for TLR7 (if available)
TreeFam:
Gene Tree for TLR7 (if available)

Paralogs for TLR7 Gene

Paralogs for TLR7 Gene

(2) SIMAP similar genes for TLR7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TLR7: view

Variants for TLR7 Gene

Sequence variations from dbSNP and Humsavar for TLR7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5743781 - 12,886,851(+) AAATG(C/T)CAGAA reference, missense
rs179008 - 12,885,540(+) GAGAC(A/C/T)AATTC reference, missense
rs179009 -- 12,885,361(-) CCCCA(A/C/T)GACTG intron-variant
rs179010 -- 12,884,766(+) TCACC(C/T)AGGCA intron-variant
rs179011 -- 12,883,841(-) TCACC(A/C)CCCTA intron-variant

Variation tolerance for TLR7 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR7 Gene

HapMap Linkage Disequilibrium report
TLR7
Human Gene Mutation Database (HGMD)
TLR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR7 Gene

Disorders for TLR7 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TLR7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
superficial basal cell carcinoma
  • multicentric basal cell carcinoma
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
congenital heart block
  • heart block congenital
viral infectious disease
  • arbovirus infectious disease
juvenile nasopharyngeal angiofibroma
  • jna
- elite association - COSMIC cancer census association via MalaCards
Search TLR7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR7

Genetic Association Database (GAD)
TLR7
Human Genome Epidemiology (HuGE) Navigator
TLR7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR7
genes like me logo Genes that share disorders with TLR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR7 Gene

Publications for TLR7 Gene

  1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X. … Beutler B. (Eur. Cytokine Netw. 2000) 2 3 4 67
  2. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. (PMID: 19821521) Chang S. … Szabo G. (Hepatology 2010) 3 23
  3. Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells. (PMID: 20007807) Colisson R. … Herbeuval J.P. (Blood 2010) 3 23
  4. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. (PMID: 20042593) Goutagny N. … Fitzgerald K.A. (J. Immunol. 2010) 3 23
  5. TLR activation pathways in HIV-1-exposed seronegative individuals. (PMID: 20124101) Biasin M. … Clerici M. (J. Immunol. 2010) 3 23

Products for TLR7 Gene

  • Addgene plasmids for TLR7

Sources for TLR7 Gene

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