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Aliases for CDK17 Gene

Aliases for CDK17 Gene

  • Cyclin-Dependent Kinase 17 2 3
  • Serine/Threonine-Protein Kinase PCTAIRE-2 3 4
  • Cell Division Protein Kinase 17 3 4
  • PCTAIRE-Motif Protein Kinase 2 3 4
  • EC 2.7.11.22 4 63
  • PCTAIRE2 3 4
  • PCTK2 3 4
  • Protein Kinase Cdc2-Related PCTAIRE-2 3
  • PCTAIRE Protein Kinase 2 2
  • EC 2.7.11 63

External Ids for CDK17 Gene

Previous Symbols for CDK17 Gene

  • PCTK2

Summaries for CDK17 Gene

Entrez Gene Summary for CDK17 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

GeneCards Summary for CDK17 Gene

CDK17 (Cyclin-Dependent Kinase 17) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK17 Gene

  • May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Gene Wiki entry for CDK17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK17 Gene

Genomics for CDK17 Gene

Genomic Location for CDK17 Gene

Start:
96,278,261 bp from pter
End:
96,400,588 bp from pter
Size:
122,328 bases
Orientation:
Minus strand

Genomic View for CDK17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK17 Gene

No data available for Regulatory Elements for CDK17 Gene

Proteins for CDK17 Gene

  • Protein details for CDK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00537-CDK17_HUMAN
    Recommended name:
    Cyclin-dependent kinase 17
    Protein Accession:
    Q00537
    Secondary Accessions:
    • A8K1U6
    • B2RCQ2
    • Q8NEB8

    Protein attributes for CDK17 Gene

    Size:
    523 amino acids
    Molecular mass:
    59582 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).

    Alternative splice isoforms for CDK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK17 Gene

Proteomics data for CDK17 Gene at MOPED

Post-translational modifications for CDK17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys452 and Lys493

Domains for CDK17 Gene

Gene Families for CDK17 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK17 Gene

Graphical View of Domain Structure for InterPro Entry

Q00537

UniProtKB/Swiss-Prot:

CDK17_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q00537
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • Q00537
genes like me logo Genes that share domains with CDK17: view

Function for CDK17 Gene

Molecular function for CDK17 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Enzyme Numbers (IUBMB) for CDK17 Gene

Gene Ontology (GO) - Molecular Function for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 1639063
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15161933
genes like me logo Genes that share ontologies with CDK17: view
genes like me logo Genes that share phenotypes with CDK17: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK17 Gene

Localization for CDK17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK17 Gene COMPARTMENTS Subcellular localization image for CDK17 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK17 Gene

Pathways for CDK17 Gene

SuperPathways for CDK17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK17: view

No data available for Pathways by source for CDK17 Gene

Compounds for CDK17 Gene

(2) HMDB Compounds for CDK17 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CDK17: view

Transcripts for CDK17 Gene

Unigene Clusters for CDK17 Gene

Cyclin-dependent kinase 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK17 Gene

No ASD Table

Relevant External Links for CDK17 Gene

GeneLoc Exon Structure for
CDK17
ECgene alternative splicing isoforms for
CDK17

Expression for CDK17 Gene

mRNA expression in normal human tissues for CDK17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK17 Gene

SOURCE GeneReport for Unigene cluster for CDK17 Gene Hs.506415

genes like me logo Genes that share expressions with CDK17: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK17 Gene

Orthologs for CDK17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK17 35
  • 99.62 (n)
  • 100 (a)
CDK17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK17 35
  • 95.6 (n)
  • 99.04 (a)
CDK17 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK17 35
  • 94.65 (n)
  • 97.9 (a)
CDK17 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk17 35
  • 90.57 (n)
  • 98.66 (a)
Cdk17 16
Cdk17 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK17 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk17 35
  • 90.57 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves CDK17 35
  • 84.64 (n)
  • 97.9 (a)
CDK17 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK17 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk17 35
  • 79.66 (n)
  • 92.51 (a)
Str.17214 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10983 35
zebrafish
(Danio rerio)
Actinopterygii cdk16 36
  • 91 (a)
OneToOne
Dr.26649 35
LOC798487 35
  • 75.08 (n)
  • 91.59 (a)
worm
(Caenorhabditis elegans)
Secernentea pct-1 35
  • 58.21 (n)
  • 56.65 (a)
pct-1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 36
  • 61 (a)
OneToMany
Species with no ortholog for CDK17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK17 Gene

ENSEMBL:
Gene Tree for CDK17 (if available)
TreeFam:
Gene Tree for CDK17 (if available)

Paralogs for CDK17 Gene

Paralogs for CDK17 Gene

genes like me logo Genes that share paralogs with CDK17: view

Variants for CDK17 Gene

Sequence variations from dbSNP and Humsavar for CDK17 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs719042 -- 96,331,646(+) TAATA(C/T)CTCAT intron-variant
rs1193560 -- 96,347,322(+) acttt(A/G)ggagg intron-variant
rs1193561 -- 96,347,346(+) atcac(C/T)tgagg intron-variant
rs1193562 -- 96,347,370(+) accag(C/T)ctggc intron-variant
rs1209227 -- 96,347,329(+) gaggc(A/C)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK17 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv836 CNV Insertion 18451855
esv269643 CNV Insertion 20981092
esv272651 CNV Insertion 20981092
nsv53730 CNV Insertion 16902084
nsv899457 CNV Gain 21882294
esv2676742 CNV Deletion 23128226

Relevant External Links for CDK17 Gene

HapMap Linkage Disequilibrium report
CDK17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK17 Gene

Disorders for CDK17 Gene

Relevant External Links for CDK17

Genetic Association Database (GAD)
CDK17
Human Genome Epidemiology (HuGE) Navigator
CDK17
genes like me logo Genes that share disorders with CDK17: view

No data available for UniProtKB/Swiss-Prot for CDK17 Gene

Publications for CDK17 Gene

  1. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 3 4
  2. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. (PMID: 9370357) Hirose T. … Okada M. (Eur. J. Biochem. 1997) 2 3
  3. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CDK17 Gene

  • Addgene plasmids for CDK17

Sources for CDK17 Gene

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