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Aliases for CDK17 Gene

Aliases for CDK17 Gene

  • Cyclin-Dependent Kinase 17 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-2 3 4
  • Cell Division Protein Kinase 17 3 4
  • PCTAIRE-Motif Protein Kinase 2 3 4
  • EC 2.7.11.22 4 63
  • PCTAIRE2 3 4
  • PCTK2 3 4
  • Protein Kinase Cdc2-Related PCTAIRE-2 3
  • PCTAIRE Protein Kinase 2 2
  • EC 2.7.11 63

External Ids for CDK17 Gene

Previous HGNC Symbols for CDK17 Gene

  • PCTK2

Previous GeneCards Identifiers for CDK17 Gene

  • GC12M095196
  • GC12M096673
  • GC12M093733

Summaries for CDK17 Gene

Entrez Gene Summary for CDK17 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

GeneCards Summary for CDK17 Gene

CDK17 (Cyclin-Dependent Kinase 17) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK17 Gene

  • May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Gene Wiki entry for CDK17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK17 Gene

Genomics for CDK17 Gene

Regulatory Elements for CDK17 Gene

Enhancers for CDK17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK17 on UCSC Golden Path with GeneCards custom track

Promoters for CDK17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK17 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK17 Gene

Chromosome:
12
Start:
96,278,261 bp from pter
End:
96,400,588 bp from pter
Size:
122,328 bases
Orientation:
Minus strand

Genomic View for CDK17 Gene

Genes around CDK17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK17 Gene

Proteins for CDK17 Gene

  • Protein details for CDK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00537-CDK17_HUMAN
    Recommended name:
    Cyclin-dependent kinase 17
    Protein Accession:
    Q00537
    Secondary Accessions:
    • A8K1U6
    • B2RCQ2
    • Q8NEB8

    Protein attributes for CDK17 Gene

    Size:
    523 amino acids
    Molecular mass:
    59582 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity).

    Alternative splice isoforms for CDK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK17 Gene

Proteomics data for CDK17 Gene at MOPED

Post-translational modifications for CDK17 Gene

  • Ubiquitination at Lys 452 and Lys 493
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK17 Gene

Gene Families for CDK17 Gene

Suggested Antigen Peptide Sequences for CDK17 Gene

Graphical View of Domain Structure for InterPro Entry

Q00537

UniProtKB/Swiss-Prot:

CDK17_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK17: view

Function for CDK17 Gene

Molecular function for CDK17 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Enzyme Numbers (IUBMB) for CDK17 Gene

Gene Ontology (GO) - Molecular Function for CDK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 1639063
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK17: view
genes like me logo Genes that share phenotypes with CDK17: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK17 Gene

Localization for CDK17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK17 Gene COMPARTMENTS Subcellular localization image for CDK17 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK17 Gene

Pathways & Interactions for CDK17 Gene

SuperPathways for CDK17 Gene

No Data Available

Pathways by source for CDK17 Gene

1 GeneTex pathway for CDK17 Gene

Gene Ontology (GO) - Biological Process for CDK17 Gene

None

No data available for SIGNOR curated interactions for CDK17 Gene

Drugs & Compounds for CDK17 Gene

(1) Drugs for CDK17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK17: view

Transcripts for CDK17 Gene

Unigene Clusters for CDK17 Gene

Cyclin-dependent kinase 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK17 Gene

No ASD Table

Relevant External Links for CDK17 Gene

GeneLoc Exon Structure for
CDK17
ECgene alternative splicing isoforms for
CDK17

Expression for CDK17 Gene

mRNA expression in normal human tissues for CDK17 Gene

Protein differential expression in normal tissues from HIPED for CDK17 Gene

This gene is overexpressed in Urine (36.2), Amniocyte (9.4), and Placenta (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK17 Gene



SOURCE GeneReport for Unigene cluster for CDK17 Gene Hs.506415

genes like me logo Genes that share expression patterns with CDK17: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDK17 Gene

Orthologs for CDK17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK17 35
  • 95.6 (n)
  • 99.04 (a)
CDK17 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK17 35
  • 94.65 (n)
  • 97.9 (a)
CDK17 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk17 35
  • 90.57 (n)
  • 98.66 (a)
Cdk17 16
Cdk17 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK17 35
  • 99.62 (n)
  • 100 (a)
CDK17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk17 35
  • 90.57 (n)
  • 98.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK17 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK17 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK17 35
  • 84.64 (n)
  • 97.9 (a)
CDK17 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK17 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk17 35
  • 79.66 (n)
  • 92.51 (a)
Str.17214 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26649 35
LOC798487 35
  • 75.08 (n)
  • 91.59 (a)
cdk16 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10983 35
worm
(Caenorhabditis elegans)
Secernentea pct-1 35
  • 58.21 (n)
  • 56.65 (a)
pct-1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 36
  • 61 (a)
OneToMany
Species with no ortholog for CDK17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK17 Gene

ENSEMBL:
Gene Tree for CDK17 (if available)
TreeFam:
Gene Tree for CDK17 (if available)

Paralogs for CDK17 Gene

Paralogs for CDK17 Gene

genes like me logo Genes that share paralogs with CDK17: view

Variants for CDK17 Gene

Sequence variations from dbSNP and Humsavar for CDK17 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_064743 -
rs1965149 -- 96,362,365(+) AGGCA(C/T)ACACC intron-variant
rs1965150 -- 96,373,703(+) gatca(C/T)aaggt intron-variant
rs1982221 -- 96,338,527(+) CTCCA(A/G)CTTTT intron-variant
rs1982222 -- 96,338,579(+) agaga(C/T)ggagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK17 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv836 CNV Insertion 18451855
esv269643 CNV Insertion 20981092
esv272651 CNV Insertion 20981092
nsv53730 CNV Insertion 16902084
nsv899457 CNV Gain 21882294
esv2676742 CNV Deletion 23128226

Variation tolerance for CDK17 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK17 Gene

HapMap Linkage Disequilibrium report
CDK17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK17 Gene

Disorders for CDK17 Gene

Relevant External Links for CDK17

Genetic Association Database (GAD)
CDK17
Human Genome Epidemiology (HuGE) Navigator
CDK17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK17

No disorders were found for CDK17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK17 Gene

Publications for CDK17 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. (PMID: 9370357) Hirose T. … Okada M. (Eur. J. Biochem. 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CDK17 Gene

Sources for CDK17 Gene

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