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Aliases for KLF3 Gene

Aliases for KLF3 Gene

  • Kruppel-Like Factor 3 (Basic) 2 3 5
  • CACCC-Box-Binding Protein BKLF 3 4
  • Basic Krueppel-Like Factor 3 4
  • Basic Kruppel-Like Factor 2 3
  • TEF-2 3 4
  • BKLF 3 4
  • Basic Kruppel Like Factor 3
  • Transcript Ch138 3

External Ids for KLF3 Gene

Previous GeneCards Identifiers for KLF3 Gene

  • GC04P038830
  • GC04P038500
  • GC04P038563
  • GC04P038488
  • GC04P038342
  • GC04P037989

Summaries for KLF3 Gene

GeneCards Summary for KLF3 Gene

KLF3 (Kruppel-Like Factor 3 (Basic)) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF3 Gene

  • Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

Gene Wiki entry for KLF3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF3 Gene

Genomics for KLF3 Gene

Regulatory Elements for KLF3 Gene

Enhancers for KLF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF3 on UCSC Golden Path with GeneCards custom track

Promoters for KLF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF3 Gene

38,664,169 bp from pter
38,701,508 bp from pter
37,340 bases
Plus strand

Genomic View for KLF3 Gene

Genes around KLF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF3 Gene

Proteins for KLF3 Gene

  • Protein details for KLF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 3
    Protein Accession:
    Secondary Accessions:
    • Q6PIR1
    • Q86TN0
    • Q9P2X6

    Protein attributes for KLF3 Gene

    345 amino acids
    Molecular mass:
    38829 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for KLF3 Gene


neXtProt entry for KLF3 Gene

Proteomics data for KLF3 Gene at MOPED

Post-translational modifications for KLF3 Gene

  • Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF3 Gene

Domains & Families for KLF3 Gene

Protein Domains for KLF3 Gene

Suggested Antigen Peptide Sequences for KLF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF3: view

Function for KLF3 Gene

Molecular function for KLF3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

Gene Ontology (GO) - Molecular Function for KLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLF3: view
genes like me logo Genes that share phenotypes with KLF3: view

Animal Models for KLF3 Gene

MGI Knock Outs for KLF3:

Animal Model Products

Targeted motifs for KLF3 Gene
HOMER Transcription Factor Regulatory Elements motif KLF3
  • Consensus sequence: NRGCCCCRCCCHBNN Submotif: canonical Cell Type: MEF GEO ID: GSE44748

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF3 Gene

Localization for KLF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF3 Gene

Subcellular locations from

Jensen Localization Image for KLF3 Gene COMPARTMENTS Subcellular localization image for KLF3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for KLF3 Gene

Pathways & Interactions for KLF3 Gene

genes like me logo Genes that share pathways with KLF3: view

Pathways by source for KLF3 Gene

1 KEGG pathway for KLF3 Gene

SIGNOR curated interactions for KLF3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 10582345
GO:1901653 cellular response to peptide IEA --
genes like me logo Genes that share ontologies with KLF3: view

Drugs & Compounds for KLF3 Gene

(1) Drugs for KLF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF3: view

Transcripts for KLF3 Gene

mRNA/cDNA for KLF3 Gene

Unigene Clusters for KLF3 Gene

Kruppel-like factor 3 (basic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF3 Gene

No ASD Table

Relevant External Links for KLF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF3 Gene

mRNA expression in normal human tissues for KLF3 Gene

Protein differential expression in normal tissues from HIPED for KLF3 Gene

This gene is overexpressed in CD8 Tcells (44.6) and CD4 Tcells (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF3 Gene

SOURCE GeneReport for Unigene cluster for KLF3 Gene Hs.298658

genes like me logo Genes that share expression patterns with KLF3: view

Protein tissue co-expression partners for KLF3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLF3 Gene

Orthologs for KLF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLF3 35
  • 90.14 (n)
  • 97.39 (a)
KLF3 36
  • 97 (a)
(Canis familiaris)
Mammalia KLF3 35
  • 87.73 (n)
  • 95.65 (a)
KLF3 36
  • 96 (a)
(Mus musculus)
Mammalia Klf3 35
  • 86.92 (n)
  • 95.64 (a)
Klf3 16
Klf3 36
  • 96 (a)
(Pan troglodytes)
Mammalia KLF3 35
  • 99.9 (n)
  • 100 (a)
KLF3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klf3 35
  • 87.4 (n)
  • 96.22 (a)
(Monodelphis domestica)
Mammalia KLF3 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia KLF3 36
  • 84 (a)
(Gallus gallus)
Aves KLF3 35
  • 75.58 (n)
  • 80.81 (a)
KLF3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia KLF3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klf3 35
  • 68.53 (n)
  • 70.59 (a)
(Danio rerio)
Actinopterygii klf3 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 37
  • 76 (a)
CG9895 37
  • 74 (a)
CG42741 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010520 35
  • 68.94 (n)
  • 79.55 (a)
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 62 (a)
F56F11.3 37
  • 72 (a)
mua-1 37
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for KLF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF3 Gene

Gene Tree for KLF3 (if available)
Gene Tree for KLF3 (if available)

Paralogs for KLF3 Gene

Paralogs for KLF3 Gene

(6) SIMAP similar genes for KLF3 Gene using alignment to 1 proteins: Pseudogenes for KLF3 Gene

genes like me logo Genes that share paralogs with KLF3: view

Variants for KLF3 Gene

Sequence variations from dbSNP and Humsavar for KLF3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17616226 - 38,689,805(+) CAGAG(C/G)ACAGA nc-transcript-variant, reference, missense
rs7147 -- 38,700,816(+) CATGC(A/G)TTAGT utr-variant-3-prime
rs180041 -- 38,673,890(+) GAGCA(C/G)ATGGG intron-variant
rs337611 -- 38,676,396(+) agatc(A/G)ttcca intron-variant
rs337612 -- 38,677,021(+) AGTGG(C/T)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF3 Gene

Variant ID Type Subtype PubMed ID
nsv822539 CNV Gain 20364138
esv22862 CNV Loss 19812545
nsv461336 CNV Loss 19166990
nsv524237 CNV Loss 19592680

Variation tolerance for KLF3 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLF3 Gene

Disorders for KLF3 Gene

Relevant External Links for KLF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF3 Gene

Publications for KLF3 Gene

  1. cDNA cloning, subcellular localization and tissue expression of a new human Kruppel-like transcription factor: human basic Kruppel-like factor (hBKLF). (PMID: 12812068) Wang M.J. … He F.C. (Yi Chuan Xue Bao 2003) 3 4 23 67
  2. Targeted disruption of the basic KrA1ppel-like factor gene (Klf3) reveals a role in adipogenesis. (PMID: 18391014) Sue N. … Crossley M. (Mol. Cell. Biol. 2008) 2 3
  3. Role for SUMO modification in facilitating transcriptional repression by BKLF. (PMID: 15684403) Perdomo J. … Crossley M. (Mol. Cell. Biol. 2005) 3 23
  4. The LIM protein FHL3 binds basic KrA1ppel-like factor/KrA1ppel-like factor 3 and its co-repressor C-terminal-binding protein 2. (PMID: 12556451) Turner J. … Crossley M. (J. Biol. Chem. 2003) 3 23
  5. Cloning and characterization of mCtBP2, a co-repressor that associates with basic KrA1ppel-like factor and other mammalian transcriptional regulators. (PMID: 9724649) Turner J. … Crossley M. (EMBO J. 1998) 3 23

Products for KLF3 Gene

Sources for KLF3 Gene