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Aliases for MRPL37 Gene

Aliases for MRPL37 Gene

  • Mitochondrial Ribosomal Protein L37 2 3
  • 39S Ribosomal Protein L2, Mitochondrial 3 4
  • MRP-L37 3 4
  • MRP-L2 3 4
  • L37mt 3 4
  • MRPL2 3 4
  • RPML2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L37, Mitochondrial 3
  • Ribosomal Protein, Mitochondrial, L2 3

External Ids for MRPL37 Gene

Previous GeneCards Identifiers for MRPL37 Gene

  • GC01P054495
  • GC01P053554
  • GC01P054023
  • GC01P054035
  • GC01P054378
  • GC01P054649
  • GC01P052781

Summaries for MRPL37 Gene

Entrez Gene Summary for MRPL37 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL37 Gene

MRPL37 (Mitochondrial Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL37 Gene

Genomics for MRPL37 Gene

Regulatory Elements for MRPL37 Gene

Genomic Location for MRPL37 Gene

Start:
54,184,041 bp from pter
End:
54,226,682 bp from pter
Size:
42,642 bases
Orientation:
Plus strand

Genomic View for MRPL37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL37 Gene

Proteins for MRPL37 Gene

  • Protein details for MRPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE1-RM37_HUMAN
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Protein Accession:
    Q9BZE1
    Secondary Accessions:
    • Q96Q67
    • Q9BWR1
    • Q9P0P3

    Protein attributes for MRPL37 Gene

    Size:
    423 amino acids
    Molecular mass:
    48117 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36155.1; Type=Frameshift; Positions=9, 13, 25, 30, 326; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL37 Gene

neXtProt entry for MRPL37 Gene

Proteomics data for MRPL37 Gene at MOPED

Post-translational modifications for MRPL37 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL37 Gene

No data available for DME Specific Peptides for MRPL37 Gene

Domains for MRPL37 Gene

Gene Families for MRPL37 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL37 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZE1

UniProtKB/Swiss-Prot:

RM37_HUMAN :
  • Q9BZE1
Family:
  • Belongs to the ribosomal protein S30/L37 family.
genes like me logo Genes that share domains with MRPL37: view

Function for MRPL37 Gene

Gene Ontology (GO) - Molecular Function for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL37: view

miRNA for MRPL37 Gene

miRTarBase miRNAs that target MRPL37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL37 Gene

Localization for MRPL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL37 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL37 Gene COMPARTMENTS Subcellular localization image for MRPL37 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL37: view

Pathways for MRPL37 Gene

SuperPathways for MRPL37 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL37: view

Pathways by source for MRPL37 Gene

1 KEGG pathway for MRPL37 Gene

Gene Ontology (GO) - Biological Process for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL37: view

Transcripts for MRPL37 Gene

Unigene Clusters for MRPL37 Gene

Mitochondrial ribosomal protein L37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for MRPL37 Gene

GeneLoc Exon Structure for
MRPL37
ECgene alternative splicing isoforms for
MRPL37

Expression for MRPL37 Gene

mRNA expression in normal human tissues for MRPL37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL37 Gene

SOURCE GeneReport for Unigene cluster for MRPL37 Gene Hs.584908

genes like me logo Genes that share expressions with MRPL37: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL37 Gene

Orthologs for MRPL37 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL37 35
  • 99.21 (n)
  • 99.05 (a)
MRPL37 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
OneToMany
MRPL37 35
  • 85.26 (n)
  • 82.98 (a)
MRPL37 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRPL37 35
  • 85.42 (n)
  • 79.91 (a)
MRPL37 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl37 35
  • 82.27 (n)
  • 79.91 (a)
Mrpl37 16
Mrpl37 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL37 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL37 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl37 35
  • 82.35 (n)
  • 79.2 (a)
chicken
(Gallus gallus)
Aves MRPL37 35
  • 64.14 (n)
  • 57.11 (a)
MRPL37 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL37 36
  • 39 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25339 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl37 35
  • 59.45 (n)
  • 53.56 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl37 35
  • 59.25 (n)
  • 52.55 (a)
mrpl37 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002400 35
  • 41.41 (n)
  • 31.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL37 35
  • 45.14 (n)
  • 29.15 (a)
mRpL37 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8616 36
  • 25 (a)
OneToOne
Species with no ortholog for MRPL37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL37 Gene

ENSEMBL:
Gene Tree for MRPL37 (if available)
TreeFam:
Gene Tree for MRPL37 (if available)

Paralogs for MRPL37 Gene

Pseudogenes.org Pseudogenes for MRPL37 Gene

genes like me logo Genes that share paralogs with MRPL37: view

No data available for Paralogs for MRPL37 Gene

Variants for MRPL37 Gene

Sequence variations from dbSNP and Humsavar for MRPL37 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6621 -- 54,218,252(+) TGAGC(A/C/G)GAGGA utr-variant-3-prime, intron-variant
rs13571 - 54,216,247(-) CGTTA(C/G)AGTCC missense, reference
rs15921 -- 54,218,183(+) GTTGG(C/G)CCAGT reference, synonymous-codon, intron-variant
rs610851 -- 54,220,244(+) TGAAC(C/T)TGAGC intron-variant
rs612711 -- 54,220,701(+) GGAAC(C/T)TGAGG intron-variant

Relevant External Links for MRPL37 Gene

HapMap Linkage Disequilibrium report
MRPL37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL37 Gene

Disorders for MRPL37 Gene

Relevant External Links for MRPL37

Genetic Association Database (GAD)
MRPL37
Human Genome Epidemiology (HuGE) Navigator
MRPL37
genes like me logo Genes that share disorders with MRPL37: view

No data available for UniProtKB/Swiss-Prot for MRPL37 Gene

Publications for MRPL37 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. [The structure and specific features of the cDNA expression of the human gene MRPL37]. (PMID: 15562971) Levshenkova E.V. … Frolova E.I. (Bioorg. Khim. 2004) 3 23
  3. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. (PMID: 10600119) Graack H.R. … O'Brien T.W. (Biochemistry 1999) 2 3
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4

Products for MRPL37 Gene

Sources for MRPL37 Gene

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