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Aliases for CRIM1 Gene

Aliases for CRIM1 Gene

  • Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) 2 3 5
  • Cysteine-Rich Repeat-Containing Protein S52 3 4
  • CRIM-1 3 4
  • S52 3 4
  • Cysteine-Rich Motor Neuron 1 2

External Ids for CRIM1 Gene

Previous HGNC Symbols for CRIM1 Gene

  • S52

Previous GeneCards Identifiers for CRIM1 Gene

  • GC02P036548
  • GC02P036730
  • GC02P036557
  • GC02P036495
  • GC02P036583

Summaries for CRIM1 Gene

Entrez Gene Summary for CRIM1 Gene

  • This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

GeneCards Summary for CRIM1 Gene

CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and enzyme inhibitor activity. An important paralog of this gene is KCP.

UniProtKB/Swiss-Prot for CRIM1 Gene

  • May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Gene Wiki entry for CRIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIM1 Gene

Genomics for CRIM1 Gene

Regulatory Elements for CRIM1 Gene

Enhancers for CRIM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRIM1 on UCSC Golden Path with GeneCards custom track

Promoters for CRIM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRIM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRIM1 Gene

Chromosome:
2
Start:
36,355,771 bp from pter
End:
36,551,135 bp from pter
Size:
195,365 bases
Orientation:
Plus strand

Genomic View for CRIM1 Gene

Genes around CRIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIM1 Gene

Proteins for CRIM1 Gene

  • Protein details for CRIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZV1-CRIM1_HUMAN
    Recommended name:
    Cysteine-rich motor neuron 1 protein
    Protein Accession:
    Q9NZV1
    Secondary Accessions:
    • Q2M2G4
    • Q59GH0
    • Q7LCQ5
    • Q9H318

    Protein attributes for CRIM1 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113738 Da
    Quaternary structure:
    • Interacts with BMP4 and BMP7.
    SequenceCaution:
    • Sequence=BAD92376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CRIM1 Gene

Proteomics data for CRIM1 Gene at MOPED

Post-translational modifications for CRIM1 Gene

Other Protein References for CRIM1 Gene

Antibody Products

No data available for DME Specific Peptides for CRIM1 Gene

Domains & Families for CRIM1 Gene

Protein Domains for CRIM1 Gene

Suggested Antigen Peptide Sequences for CRIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZV1

UniProtKB/Swiss-Prot:

CRIM1_HUMAN :
  • Contains 4 antistasin-like domains.
Domain:
  • Contains 4 antistasin-like domains.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 6 VWFC domains.
genes like me logo Genes that share domains with CRIM1: view

No data available for Gene Families for CRIM1 Gene

Function for CRIM1 Gene

Molecular function for CRIM1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Gene Ontology (GO) - Molecular Function for CRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0030165 PDZ domain binding IDA 23209302
genes like me logo Genes that share ontologies with CRIM1: view
genes like me logo Genes that share phenotypes with CRIM1: view

Animal Models for CRIM1 Gene

MGI Knock Outs for CRIM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRIM1

miRNA for CRIM1 Gene

miRTarBase miRNAs that target CRIM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRIM1 Gene

Localization for CRIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIM1 Gene

Processed cysteine-rich motor neuron 1 protein: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIM1 Gene COMPARTMENTS Subcellular localization image for CRIM1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CRIM1 Gene

Pathways & Interactions for CRIM1 Gene

SuperPathways for CRIM1 Gene

No Data Available

Interacting Proteins for CRIM1 Gene

Gene Ontology (GO) - Biological Process for CRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 10642437
genes like me logo Genes that share ontologies with CRIM1: view

No data available for Pathways by source and SIGNOR curated interactions for CRIM1 Gene

Drugs & Compounds for CRIM1 Gene

No Compound Related Data Available

Transcripts for CRIM1 Gene

Unigene Clusters for CRIM1 Gene

Cysteine rich transmembrane BMP regulator 1 (chordin-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2:
SP3: - -
SP4: - - - -
SP5:
SP6:

ExUns: 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CRIM1 Gene

GeneLoc Exon Structure for
CRIM1
ECgene alternative splicing isoforms for
CRIM1

Expression for CRIM1 Gene

mRNA expression in normal human tissues for CRIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRIM1 Gene

This gene is overexpressed in Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for CRIM1 Gene

This gene is overexpressed in Amniocyte (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIM1 Gene



SOURCE GeneReport for Unigene cluster for CRIM1 Gene Hs.699247

mRNA Expression by UniProt/SwissProt for CRIM1 Gene

Q9NZV1-CRIM1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
genes like me logo Genes that share expression patterns with CRIM1: view

Protein tissue co-expression partners for CRIM1 Gene

Primer Products

Orthologs for CRIM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRIM1 35
  • 89.31 (n)
  • 88.41 (a)
CRIM1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRIM1 35
  • 91.28 (n)
  • 91.8 (a)
CRIM1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crim1 35
  • 87.81 (n)
  • 89.19 (a)
Crim1 16
Crim1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRIM1 35
  • 98.88 (n)
  • 98.83 (a)
CRIM1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crim1 35
  • 87.93 (n)
  • 89.48 (a)
oppossum
(Monodelphis domestica)
Mammalia CRIM1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRIM1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRIM1 35
  • 79.7 (n)
  • 82.84 (a)
CRIM1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRIM1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488895 35
  • 75.78 (n)
  • 80.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12291 35
zebrafish
(Danio rerio)
Actinopterygii crim1 35
  • 69.54 (n)
  • 71.47 (a)
crim1 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crm-1 35
  • 48.25 (n)
  • 40.21 (a)
crm-1 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for CRIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIM1 Gene

ENSEMBL:
Gene Tree for CRIM1 (if available)
TreeFam:
Gene Tree for CRIM1 (if available)

Paralogs for CRIM1 Gene

Paralogs for CRIM1 Gene

(1) SIMAP similar genes for CRIM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CRIM1: view

Variants for CRIM1 Gene

Sequence variations from dbSNP and Humsavar for CRIM1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12997487 - 36,509,985(+) CAGCC(A/G)AGGAA nc-transcript-variant, reference, missense
rs59929305 - 36,522,226(+) ATAGC(A/G)TAATT intron-variant, nc-transcript-variant, reference, missense
rs711245 -- 36,541,732(-) GATCA(C/T)GGGCA intron-variant
rs711246 -- 36,541,576(-) GGCGA(C/G)GTGCT intron-variant
rs711247 -- 36,529,145(-) GGACC(A/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRIM1 Gene

Variant ID Type Subtype PubMed ID
dgv1170e1 CNV Complex 17122850
nsv2680 CNV Insertion 18451855
nsv833803 CNV Gain 17160897
dgv1171e1 CNV Complex 17122850
esv2536024 CNV Deletion 19546169
esv2719922 CNV Deletion 23290073
esv1790942 CNV Deletion 17803354
nsv213151 CNV Loss 16902084
esv2664333 CNV Deletion 23128226

Variation tolerance for CRIM1 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIM1 Gene

Human Gene Mutation Database (HGMD)
CRIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIM1 Gene

Disorders for CRIM1 Gene

Relevant External Links for CRIM1

Genetic Association Database (GAD)
CRIM1
Human Genome Epidemiology (HuGE) Navigator
CRIM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRIM1

No disorders were found for CRIM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIM1 Gene

Publications for CRIM1 Gene

  1. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. (PMID: 10642437) Kolle G.V. … Yamada T. (Mech. Dev. 2000) 2 3 4 67
  2. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. (PMID: 12805376) Wilkinson L. … Little M.H. (J. Biol. Chem. 2003) 3 23
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. CRIM1 haploinsufficiency causes defects in eye development in human and mouse. (PMID: 25561690) Beleggia F. … Wollnik B. (Hum. Mol. Genet. 2015) 3
  5. Inhibition of the proliferation and acceleration of migration of vascular endothelial cells by increased cysteine-rich motor neuron 1. (PMID: 25956066) Nakashima Y. … Takahashi S. (Biochem. Biophys. Res. Commun. 2015) 3

Products for CRIM1 Gene

Sources for CRIM1 Gene

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