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Aliases for PHF20 Gene

Aliases for PHF20 Gene

  • PHD Finger Protein 20 2 3
  • GLEA2 3 4 6
  • HCA58 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 58 3 4
  • Tudor Domain Containing 20A 2 3
  • Glioma-Expressed Antigen 2 3 4
  • Novel Zinc Finger Protein 3 4
  • Transcription Factor TZP 3 4
  • C20orf104 3 4
  • NZF 3 4
  • TZP 3 4
  • Chromosome 20 Open Reading Frame 104 2
  • TDRD20A 3

External Ids for PHF20 Gene

Previous HGNC Symbols for PHF20 Gene

  • C20orf104

Previous GeneCards Identifiers for PHF20 Gene

  • GC20P033824
  • GC20P034359
  • GC20P031137

Summaries for PHF20 Gene

GeneCards Summary for PHF20 Gene

PHF20 (PHD Finger Protein 20) is a Protein Coding gene. Diseases associated with PHF20 include large cell medulloblastoma and medulloblastoma. Among its related pathways are Chromatin Regulation / Acetylation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). An important paralog of this gene is PHF20L1.

UniProtKB/Swiss-Prot for PHF20 Gene

  • Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 Lys-16 acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.

Gene Wiki entry for PHF20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF20 Gene

Genomics for PHF20 Gene

Regulatory Elements for PHF20 Gene

Genomic Location for PHF20 Gene

Start:
35,771,974 bp from pter
End:
35,950,381 bp from pter
Size:
178,408 bases
Orientation:
Plus strand

Genomic View for PHF20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF20 Gene

Proteins for PHF20 Gene

  • Protein details for PHF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVI0-PHF20_HUMAN
    Recommended name:
    PHD finger protein 20
    Protein Accession:
    Q9BVI0
    Secondary Accessions:
    • A7E235
    • B2RB56
    • E1P5S3
    • Q566Q2
    • Q5JWY9
    • Q66K49
    • Q9BWV4
    • Q9BXA3
    • Q9BZW3
    • Q9H421
    • Q9H4J6
    • Q9NZ22

    Protein attributes for PHF20 Gene

    Size:
    1012 amino acids
    Molecular mass:
    115386 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    Miscellaneous:
    • Antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma and childhood medulloblastula
    SequenceCaution:
    • Sequence=AAF34184.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305}; Sequence=AAK19748.1; Type=Frameshift; Positions=635, 653, 655; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF20 Gene

    Alternative splice isoforms for PHF20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF20 Gene

Proteomics data for PHF20 Gene at MOPED

Post-translational modifications for PHF20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHF20 Gene

No data available for DME Specific Peptides for PHF20 Gene

Domains for PHF20 Gene

Gene Families for PHF20 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type
  • TDRD :Tudor domain containing

Suggested Antigen Peptide Sequences for PHF20 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVI0

UniProtKB/Swiss-Prot:

PHF20_HUMAN :
  • Q9BVI0
Domain:
  • The Tudor domain 2 mediates reading of dimethyl-lysine residues
  • The Tudor domain 1 doesnt bind dimethyl-lysine residues, due to an atypical and occluded aromatic cage
  • Contains 1 A.T hook DNA-binding domain.
  • Contains 2 Tudor domains.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PHF20: view

Function for PHF20 Gene

Molecular function for PHF20 Gene

UniProtKB/Swiss-Prot Function: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 Lys-16 acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.

Gene Ontology (GO) - Molecular Function for PHF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16415788
GO:0008270 zinc ion binding IEA --
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IDA 20018852
genes like me logo Genes that share ontologies with PHF20: view
genes like me logo Genes that share phenotypes with PHF20: view

Animal Model Products

CRISPR Products

miRNA for PHF20 Gene

miRTarBase miRNAs that target PHF20

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF20

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHF20 Gene

Localization for PHF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF20 Gene COMPARTMENTS Subcellular localization image for PHF20 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for PHF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with PHF20: view

Pathways for PHF20 Gene

genes like me logo Genes that share pathways with PHF20: view

Pathways by source for PHF20 Gene

1 Cell Signaling Technology pathway for PHF20 Gene

Gene Ontology (GO) - Biological Process for PHF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043981 histone H4-K5 acetylation IDA 20018852
GO:0043982 histone H4-K8 acetylation IDA 20018852
genes like me logo Genes that share ontologies with PHF20: view

Transcripts for PHF20 Gene

Unigene Clusters for PHF20 Gene

PHD finger protein 20:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF20

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PHF20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF20 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11: - -
SP12:

ExUns: 20b ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PHF20 Gene

GeneLoc Exon Structure for
PHF20
ECgene alternative splicing isoforms for
PHF20

Expression for PHF20 Gene

mRNA expression in normal human tissues for PHF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHF20 Gene

SOURCE GeneReport for Unigene cluster for PHF20 Gene Hs.517044

mRNA Expression by UniProt/SwissProt for PHF20 Gene

Q9BVI0-PHF20_HUMAN
Tissue specificity: Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues.
genes like me logo Genes that share expressions with PHF20: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PHF20 Gene

Orthologs for PHF20 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF20 35
  • 99.77 (n)
  • 99.6 (a)
PHF20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHF20 35
  • 92.25 (n)
  • 92.25 (a)
PHF20 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF20 35
  • 92.57 (n)
  • 94.46 (a)
PHF20 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf20 35
  • 87.82 (n)
  • 89.28 (a)
Phf20 16
Phf20 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF20 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF20 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf20 35
  • 88.05 (n)
  • 88.78 (a)
chicken
(Gallus gallus)
Aves PHF20 35
  • 72.09 (n)
  • 69.88 (a)
PHF20 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF20 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17757 35
tropical clawed frog
(Silurana tropicalis)
Amphibia phf20 35
  • 65.15 (n)
  • 61.29 (a)
Str.20328 35
zebrafish
(Danio rerio)
Actinopterygii phf20a 36
  • 39 (a)
OneToMany
phf20b 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MBD-R2 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for PHF20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF20 Gene

ENSEMBL:
Gene Tree for PHF20 (if available)
TreeFam:
Gene Tree for PHF20 (if available)

Paralogs for PHF20 Gene

Paralogs for PHF20 Gene

Selected SIMAP similar genes for PHF20 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PHF20: view

Variants for PHF20 Gene

Sequence variations from dbSNP and Humsavar for PHF20 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs721644 -- 35,885,342(-) gacca(A/G)aaata intron-variant
rs721645 -- 35,885,189(-) gctaa(A/G)ggtct intron-variant
rs733609 -- 35,805,152(-) ccgag(A/T)tgggc intron-variant
rs1142601 -- 35,876,984(+) tgcct(A/G)tagtc intron-variant
rs1142629 -- 35,823,406(+) GACAA(A/G)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF20 Gene

Variant ID Type Subtype PubMed ID
nsv526188 CNV Gain 19592680
nsv3366 CNV Insertion 18451855
nsv522947 CNV Gain 19592680
esv2096453 CNV Deletion 18987734
esv2722367 CNV Deletion 23290073
nsv3367 CNV Insertion 18451855
esv267652 CNV Insertion 20981092
nsv912863 CNV Loss 21882294
nsv912864 CNV Loss 21882294
esv2722368 CNV Deletion 23290073
esv2353057 CNV Deletion 18987734
nsv833964 CNV Loss 17160897

Relevant External Links for PHF20 Gene

HapMap Linkage Disequilibrium report
PHF20
Human Gene Mutation Database (HGMD)
PHF20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF20 Gene

Disorders for PHF20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PHF20 Gene including...

Search for PHF20 Gene in MalaCards »

(3) University of Copenhagen DISEASES for PHF20 Gene

Relevant External Links for PHF20

Genetic Association Database (GAD)
PHF20
genes like me logo Genes that share disorders with PHF20: view

No data available for UniProtKB/Swiss-Prot for PHF20 Gene

Publications for PHF20 Gene

  1. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. (PMID: 11703362) Fischer U. … Meese E. (Clin. Exp. Immunol. 2001) 3 4 23
  2. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PMID: 12800201) Behrends U. … Mautner J. (Int. J. Cancer 2003) 3 4 23
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4
  5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4

Products for PHF20 Gene

  • Addgene plasmids for PHF20

Sources for PHF20 Gene

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