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Aliases for ZNF219 Gene

Aliases for ZNF219 Gene

  • Zinc Finger Protein 219 2 3
  • ZFP219 3

External Ids for ZNF219 Gene

Previous GeneCards Identifiers for ZNF219 Gene

  • GC14M018930
  • GC14M015345
  • GC14M019548
  • GC14M020628
  • GC14M021558
  • GC14M001678

Summaries for ZNF219 Gene

GeneCards Summary for ZNF219 Gene

ZNF219 (Zinc Finger Protein 219) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and histamine receptor activity. An important paralog of this gene is ZNF516.

UniProtKB/Swiss-Prot for ZNF219 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF219 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF219 Gene

Genomics for ZNF219 Gene

Regulatory Elements for ZNF219 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF219 Gene

Start:
21,090,046 bp from pter
End:
21,104,722 bp from pter
Size:
14,677 bases
Orientation:
Minus strand

Genomic View for ZNF219 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF219 Gene

Proteins for ZNF219 Gene

  • Protein details for ZNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2Y4-ZN219_HUMAN
    Recommended name:
    Zinc finger protein 219
    Protein Accession:
    Q9P2Y4
    Secondary Accessions:
    • D3DS16
    • Q53Y57
    • Q8IYC1
    • Q9BW28

    Protein attributes for ZNF219 Gene

    Size:
    722 amino acids
    Molecular mass:
    76877 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF219 Gene

Proteomics data for ZNF219 Gene at MOPED

Post-translational modifications for ZNF219 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF219 Gene

Domains for ZNF219 Gene

Gene Families for ZNF219 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF219 Gene

Suggested Antigen Peptide Sequences for ZNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2Y4

UniProtKB/Swiss-Prot:

ZN219_HUMAN :
  • Q9P2Y4
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF219: view

Function for ZNF219 Gene

Molecular function for ZNF219 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14621294
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 14621294
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IDA 14621294
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 14621294
genes like me logo Genes that share ontologies with ZNF219: view

Animal Model Products

CRISPR Products

miRNA for ZNF219 Gene

miRTarBase miRNAs that target ZNF219

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF219 Gene

Localization for ZNF219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF219 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF219 Gene COMPARTMENTS Subcellular localization image for ZNF219 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10819330
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF219: view

Pathways for ZNF219 Gene

SuperPathways for ZNF219 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14621294
GO:0001505 regulation of neurotransmitter levels IEA --
GO:0006351 transcription, DNA-templated IDA 14621294
GO:0006355 regulation of transcription, DNA-templated IMP 19549071
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF219: view

No data available for Pathways by source for ZNF219 Gene

Compounds for ZNF219 Gene

(1) HMDB Compounds for ZNF219 Gene

Compound Synonyms Cas Number PubMed IDs
Histamine
  • 1H-Imidazole-4-ethanamine
51-45-6
genes like me logo Genes that share compounds with ZNF219: view

Transcripts for ZNF219 Gene

Unigene Clusters for ZNF219 Gene

Zinc finger protein 219:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF219

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF219 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - -
SP9: - -

Relevant External Links for ZNF219 Gene

GeneLoc Exon Structure for
ZNF219
ECgene alternative splicing isoforms for
ZNF219

Expression for ZNF219 Gene

mRNA expression in normal human tissues for ZNF219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF219 Gene

SOURCE GeneReport for Unigene cluster for ZNF219 Gene Hs.250493

mRNA Expression by UniProt/SwissProt for ZNF219 Gene

Q9P2Y4-ZN219_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ZNF219: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF219 Gene

Orthologs for ZNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF219 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF219 35
  • 99.77 (n)
  • 99.86 (a)
ZNF219 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF219 35
  • 89.48 (n)
  • 92.88 (a)
ZNF219 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF219 35
  • 84.91 (n)
  • 86.31 (a)
ZNF219 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp219 35
  • 82.89 (n)
  • 88.35 (a)
Zfp219 16
Zfp219 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF219 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF219 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp219 35
  • 83.36 (n)
  • 88.9 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF219 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495520 35
  • 52.47 (n)
  • 50.98 (a)
zebrafish
(Danio rerio)
Actinopterygii ZNF219 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 36
  • 19 (a)
OneToMany
Species with no ortholog for ZNF219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF219 Gene

ENSEMBL:
Gene Tree for ZNF219 (if available)
TreeFam:
Gene Tree for ZNF219 (if available)

Paralogs for ZNF219 Gene

Paralogs for ZNF219 Gene

genes like me logo Genes that share paralogs with ZNF219: view

Variants for ZNF219 Gene

Sequence variations from dbSNP and Humsavar for ZNF219 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1047155 -- 21,095,589(-) CATTT(G/T)TTTTA intron-variant
rs1065496 -- 21,092,547(-) GAGCC(C/G)GAGCC synonymous-codon, reference
rs3841049 -- 21,092,594(-) GCCTC(-/AGCCTC)CACCC cds-indel
rs4982409 -- 21,105,101(+) cttaa(A/G)accac upstream-variant-2KB
rs7149011 -- 21,094,401(+) AGGAT(C/T)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF219 Gene

Variant ID Type Subtype PubMed ID
nsv826882 CNV Gain 20364138
dgv123n21 CNV Loss 19592680

Relevant External Links for ZNF219 Gene

HapMap Linkage Disequilibrium report
ZNF219

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF219 Gene

Disorders for ZNF219 Gene

Relevant External Links for ZNF219

Human Genome Epidemiology (HuGE) Navigator
ZNF219
genes like me logo Genes that share disorders with ZNF219: view

No data available for UniProtKB/Swiss-Prot for ZNF219 Gene

Publications for ZNF219 Gene

  1. Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region. (PMID: 10819330) Sakai T. … Maeda H. (DNA Res. 2000) 2 3 4
  2. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. (PMID: 14621294) Sakai T. … Maeda H. (DNA Res. 2003) 3 23
  3. Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219. (PMID: 19549071) Clough R.L. … Stefanis L. (J. Neurochem. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF219 Gene

Sources for ZNF219 Gene

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