Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GLRX5 Gene

Aliases for GLRX5 Gene

  • Glutaredoxin 5 2 3
  • C14orf87 3 4 6
  • Monothiol Glutaredoxin-5 3 4
  • FLB4739 3 6
  • PRO1238 3 6
  • Glutaredoxin-Related Protein 5, Mitochondrial 3
  • Glutaredoxin 5 Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 87 2
  • Glutaredoxin 5 Homolog 3
  • PR01238 3
  • GRX5 3
  • PRSA 3

External Ids for GLRX5 Gene

Previous HGNC Symbols for GLRX5 Gene

  • C14orf87

Previous GeneCards Identifiers for GLRX5 Gene

  • GC14P095072
  • GC14P096001
  • GC14P076186

Summaries for GLRX5 Gene

Entrez Gene Summary for GLRX5 Gene

  • This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]

GeneCards Summary for GLRX5 Gene

GLRX5 (Glutaredoxin 5) is a Protein Coding gene. Diseases associated with GLRX5 include spasticity-ataxia-gait anomalies syndrome and anemia, sideroblastic, pyridoxine-refractory, autosomal recessive. Among its related pathways are PAK Pathway. GO annotations related to this gene include electron carrier activity and 2 iron, 2 sulfur cluster binding.

UniProtKB/Swiss-Prot for GLRX5 Gene

  • Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1

Gene Wiki entry for GLRX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLRX5 Gene

Genomics for GLRX5 Gene

Regulatory Elements for GLRX5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GLRX5 Gene

95,533,503 bp from pter
95,544,724 bp from pter
11,222 bases
Plus strand

Genomic View for GLRX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GLRX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLRX5 Gene

Proteins for GLRX5 Gene

  • Protein details for GLRX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutaredoxin-related protein 5, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q0X088
    • Q3YML0
    • Q86WY3
    • Q8IZ54

    Protein attributes for GLRX5 Gene

    157 amino acids
    Molecular mass:
    16628 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=CAD62364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLRX5 Gene

neXtProt entry for GLRX5 Gene

Proteomics data for GLRX5 Gene at MOPED

Post-translational modifications for GLRX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLRX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GLRX5 Gene

Domains for GLRX5 Gene

Protein Domains for GLRX5 Gene

Suggested Antigen Peptide Sequences for GLRX5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86SX6
  • Contains 1 glutaredoxin domain.
  • Belongs to the glutaredoxin family. Monothiol subfamily.
genes like me logo Genes that share domains with GLRX5: view

No data available for Gene Families for GLRX5 Gene

Function for GLRX5 Gene

Molecular function for GLRX5 Gene

UniProtKB/Swiss-Prot Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1

Gene Ontology (GO) - Molecular Function for GLRX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with GLRX5: view

Animal Model Products

CRISPR Products

miRNA for GLRX5 Gene

miRTarBase miRNAs that target GLRX5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GLRX5 Gene

Localization for GLRX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRX5 Gene


Subcellular locations from

Jensen Localization Image for GLRX5 Gene COMPARTMENTS Subcellular localization image for GLRX5 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for GLRX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with GLRX5: view

Pathways for GLRX5 Gene

SuperPathways for GLRX5 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with GLRX5: view

Pathways by source for GLRX5 Gene

1 Qiagen pathway for GLRX5 Gene

Gene Ontology (GO) - Biological Process for GLRX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030097 hemopoiesis ISS --
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GLRX5: view

Transcripts for GLRX5 Gene

mRNA/cDNA for GLRX5 Gene

Unigene Clusters for GLRX5 Gene

Glutaredoxin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GLRX5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLRX5 Gene

No ASD Table

Relevant External Links for GLRX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLRX5 Gene

mRNA expression in normal human tissues for GLRX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GLRX5 Gene

SOURCE GeneReport for Unigene cluster for GLRX5 Gene Hs.744943

genes like me logo Genes that share expressions with GLRX5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GLRX5 Gene

Orthologs for GLRX5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLRX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLRX5 35
  • 99.79 (n)
  • 100 (a)
GLRX5 36
  • 100 (a)
(Bos Taurus)
Mammalia GLRX5 35
  • 88.6 (n)
  • 88.39 (a)
GLRX5 36
  • 92 (a)
(Canis familiaris)
Mammalia GLRX5 36
  • 80 (a)
(Mus musculus)
Mammalia Glrx5 35
  • 88.6 (n)
  • 92.76 (a)
Glrx5 16
Glrx5 36
  • 94 (a)
(Monodelphis domestica)
Mammalia GLRX5 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Glrx5 35
  • 88.82 (n)
  • 91.45 (a)
(Gallus gallus)
Aves GLRX5 35
  • 76.23 (n)
  • 79.13 (a)
GLRX5 36
  • 67 (a)
(Anolis carolinensis)
Reptilia GLRX5 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glrx5 35
  • 75.07 (n)
  • 81.74 (a)
(Danio rerio)
Actinopterygii glrx5 35
  • 76.88 (n)
  • 77.48 (a)
glrx5 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002500 35
  • 69.42 (n)
  • 66.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14407 35
  • 70.54 (n)
  • 69.64 (a)
CG14407 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea glrx-5 35
  • 54.9 (n)
  • 54.9 (a)
glrx-5 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR053W 35
  • 56.23 (n)
  • 55.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRX5 35
  • 54.37 (n)
  • 51.46 (a)
GRX5 36
  • 35 (a)
GRX5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09636g 35
  • 57.52 (n)
  • 56.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04098 35
  • 60.2 (n)
  • 60.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes grx5 35
  • 50 (n)
  • 55.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4846 36
  • 54 (a)
Species with no ortholog for GLRX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLRX5 Gene

Gene Tree for GLRX5 (if available)
Gene Tree for GLRX5 (if available)

Paralogs for GLRX5 Gene

Selected SIMAP similar genes for GLRX5 Gene using alignment to 3 proteins: Pseudogenes for GLRX5 Gene

genes like me logo Genes that share paralogs with GLRX5: view

No data available for Paralogs for GLRX5 Gene

Variants for GLRX5 Gene

Sequence variations from dbSNP and Humsavar for GLRX5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs960 -- 95,544,529(-) TTTGT(C/G/T)CACCA utr-variant-3-prime
rs7120 -- 95,544,252(+) GGTTC(A/G)TGAGC utr-variant-3-prime
rs716315 -- 95,542,970(+) TGTTA(C/T)AGTCA intron-variant
rs1007813 -- 95,541,473(+) TTACA(C/T)CTATT intron-variant
rs1007814 -- 95,541,684(+) GACAT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GLRX5 Gene

Variant ID Type Subtype PubMed ID
dgv89e55 CNV Gain 17911159
esv2749054 CNV Deletion 23290073

Relevant External Links for GLRX5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRX5 Gene

Disorders for GLRX5 Gene

(1) OMIM Diseases for GLRX5 Gene (609588)


  • Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive (PRARSA) [MIM:205950]: A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. {ECO:0000269 PubMed:17485548}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for GLRX5 Gene

Relevant External Links for GLRX5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GLRX5: view

Publications for GLRX5 Gene

  1. The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. (PMID: 17485548) Camaschella C. … Iolascon A. (Blood 2007) 3 4 23
  2. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. (PMID: 19731322) Bergmann A.K. … Neufeld E.J. (Pediatr Blood Cancer 2010) 3 23
  3. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. (PMID: 20364084) Ye H. … Rouault T.A. (J. Clin. Invest. 2010) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. (PMID: 16110529) Wingert R.A. … Zon L.I. (Nature 2005) 3 4

Products for GLRX5 Gene

  • Addgene plasmids for GLRX5

Sources for GLRX5 Gene

Back to Top