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Aliases for ACP6 Gene

Aliases for ACP6 Gene

  • Acid Phosphatase 6, Lysophosphatidic 2 3 4 5
  • Acid Phosphatase-Like Protein 1 3 4
  • PACPL1 3 4
  • ACPL1 3 4
  • LPAP 3 4
  • Lysophosphatidic Acid Phosphatase 6 3
  • Lysophosphatidic Acid Phosphatase 2
  • Acid Phosphatase Like 1 3
  • EC 3.1.3.2 4

External Ids for ACP6 Gene

Previous GeneCards Identifiers for ACP6 Gene

  • GC01M145333
  • GC01M143844
  • GC01M144463
  • GC01M144626
  • GC01M144343
  • GC01M145585
  • GC01M147119
  • GC01M120532

Summaries for ACP6 Gene

GeneCards Summary for ACP6 Gene

ACP6 (Acid Phosphatase 6, Lysophosphatidic) is a Protein Coding gene. GO annotations related to this gene include acid phosphatase activity and lysophosphatidic acid phosphatase activity. An important paralog of this gene is ACPP.

UniProtKB/Swiss-Prot for ACP6 Gene

  • Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.

Gene Wiki entry for ACP6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP6 Gene

Genomics for ACP6 Gene

Regulatory Elements for ACP6 Gene

Enhancers for ACP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACP6 on UCSC Golden Path with GeneCards custom track

Promoters for ACP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACP6 Gene

Chromosome:
1
Start:
147,629,286 bp from pter
End:
147,670,512 bp from pter
Size:
41,227 bases
Orientation:
Minus strand

Genomic View for ACP6 Gene

Genes around ACP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP6 Gene

Proteins for ACP6 Gene

  • Protein details for ACP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH0-PPA6_HUMAN
    Recommended name:
    Lysophosphatidic acid phosphatase type 6
    Protein Accession:
    Q9NPH0
    Secondary Accessions:
    • Q59G61
    • Q5T490
    • Q6IAQ3
    • Q7LG81
    • Q9UIG6

    Protein attributes for ACP6 Gene

    Size:
    428 amino acids
    Molecular mass:
    48854 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACP6 Gene

    Alternative splice isoforms for ACP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACP6 Gene

Proteomics data for ACP6 Gene at MOPED

Post-translational modifications for ACP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ACP6 Gene

Domains & Families for ACP6 Gene

Gene Families for ACP6 Gene

Protein Domains for ACP6 Gene

Suggested Antigen Peptide Sequences for ACP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPH0

UniProtKB/Swiss-Prot:

PPA6_HUMAN :
  • Belongs to the histidine acid phosphatase family.
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACP6: view

Function for ACP6 Gene

Molecular function for ACP6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
UniProtKB/Swiss-Prot Induction:
Induced with the differentiation from myoblast to myotube.

Enzyme Numbers (IUBMB) for ACP6 Gene

genes like me logo Genes that share phenotypes with ACP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACP6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACP6 Gene

Localization for ACP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP6 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACP6 Gene COMPARTMENTS Subcellular localization image for ACP6 gene
Compartment Confidence
mitochondrion 5
golgi apparatus 2
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12010880
genes like me logo Genes that share ontologies with ACP6: view

Pathways & Interactions for ACP6 Gene

SuperPathways for ACP6 Gene

No Data Available

Interacting Proteins for ACP6 Gene

Gene Ontology (GO) - Biological Process for ACP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACP6: view

No data available for Pathways by source and SIGNOR curated interactions for ACP6 Gene

Drugs & Compounds for ACP6 Gene

(3) Drugs for ACP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riboflavin Approved Nutra 150
4-Nitrophenol Experimental Pharma 0
Flavin Mononucleotide Experimental Pharma 6

(78) Additional Compounds for ACP6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • 1-Monoacylglyceride
53847-30-6
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
genes like me logo Genes that share compounds with ACP6: view

Transcripts for ACP6 Gene

Unigene Clusters for ACP6 Gene

Acid phosphatase 6, lysophosphatidic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: -
SP3:
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for ACP6 Gene

GeneLoc Exon Structure for
ACP6
ECgene alternative splicing isoforms for
ACP6

Expression for ACP6 Gene

mRNA expression in normal human tissues for ACP6 Gene

Protein differential expression in normal tissues from HIPED for ACP6 Gene

This gene is overexpressed in Salivary gland (25.5), Oral epithelium (11.8), and Gallbladder (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ACP6 Gene



SOURCE GeneReport for Unigene cluster for ACP6 Gene Hs.562154

mRNA Expression by UniProt/SwissProt for ACP6 Gene

Q9NPH0-PPA6_HUMAN
Tissue specificity: Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon.
genes like me logo Genes that share expression patterns with ACP6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ACP6 Gene

Orthologs for ACP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACP6 35
  • 87.07 (n)
  • 83.88 (a)
ACP6 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACP6 35
  • 85.71 (n)
  • 81.97 (a)
ACP6 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acp6 35
  • 81.69 (n)
  • 77.22 (a)
Acp6 16
Acp6 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACP6 35
  • 99.69 (n)
  • 99.3 (a)
ACP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acp6 35
  • 81.63 (n)
  • 77.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ACP6 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACP6 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACP6 35
  • 64.2 (n)
  • 60.34 (a)
ACP6 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACP6 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acp6 35
  • 61.61 (n)
  • 55.5 (a)
zebrafish
(Danio rerio)
Actinopterygii acp6 35
  • 55.68 (n)
  • 46.32 (a)
acp6 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pho-6 36
  • 21 (a)
OneToMany
pho-7 36
  • 20 (a)
OneToMany
pho-8 36
  • 19 (a)
OneToMany
pho-9 36
  • 20 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06460 35
  • 45.36 (n)
  • 32.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4.06 35
  • 41.44 (n)
  • 31.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for ACP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACP6 Gene

ENSEMBL:
Gene Tree for ACP6 (if available)
TreeFam:
Gene Tree for ACP6 (if available)

Paralogs for ACP6 Gene

Paralogs for ACP6 Gene

genes like me logo Genes that share paralogs with ACP6: view

Variants for ACP6 Gene

Sequence variations from dbSNP and Humsavar for ACP6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6593795 - 147,650,174(+) GTCCA(C/T)GGCTT nc-transcript-variant, reference, missense
rs1344 -- 147,647,471(+) AGTGC(A/G)TGGTA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs881085 -- 147,639,081(-) CCAGG(A/G)GTTCG intron-variant
rs885239 -- 147,655,487(+) CTAGC(A/G)CAAGC intron-variant
rs870434 -- 147,637,584(-) TTCCA(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACP6 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
nsv872266 CNV Gain 21882294
nsv831426 CNV Loss 17160897

Variation tolerance for ACP6 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACP6 Gene

HapMap Linkage Disequilibrium report
ACP6
Human Gene Mutation Database (HGMD)
ACP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACP6 Gene

Disorders for ACP6 Gene

Relevant External Links for ACP6

Genetic Association Database (GAD)
ACP6
Human Genome Epidemiology (HuGE) Navigator
ACP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACP6

No disorders were found for ACP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACP6 Gene

Publications for ACP6 Gene

  1. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. (PMID: 10506173) Hiroyama M. … Takenawa T. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. (PMID: 12010880) Takayama I. … Fujino M.A. (Gut 2002) 2 3 23
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. (PMID: 23807634) Li J. … Rao Z. (Protein Cell 2013) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for ACP6 Gene

Sources for ACP6 Gene

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