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Aliases for TUBD1 Gene

Aliases for TUBD1 Gene

  • Tubulin Delta 1 2 3 5
  • Tubulin, Delta 1 2 3
  • Delta-Tubulin 3 4
  • TUBD 3 4

External Ids for TUBD1 Gene

Previous GeneCards Identifiers for TUBD1 Gene

  • GC17M057786
  • GC17M060386
  • GC17M058278
  • GC17M058412
  • GC17M055291
  • GC17M057936
  • GC17M053309

Summaries for TUBD1 Gene

GeneCards Summary for TUBD1 Gene

TUBD1 (Tubulin Delta 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot for TUBD1 Gene

  • In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Tocris Summary for TUBD1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBD1 Gene

Genomics for TUBD1 Gene

Regulatory Elements for TUBD1 Gene

Genomic Location for TUBD1 Gene

Chromosome:
17
Start:
59,859,479 bp from pter
End:
59,892,945 bp from pter
Size:
33,467 bases
Orientation:
Minus strand

Genomic View for TUBD1 Gene

Genes around TUBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBD1 Gene

Proteins for TUBD1 Gene

  • Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT1-TBD_HUMAN
    Recommended name:
    Tubulin delta chain
    Protein Accession:
    Q9UJT1
    Secondary Accessions:
    • B4DPT8
    • B4DW01
    • D3DU02
    • E9PCA7
    • E9PCQ8
    • Q5KU36
    • Q9BWG9
    • Q9H7Z8

    Protein attributes for TUBD1 Gene

    Size:
    453 amino acids
    Molecular mass:
    51034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TUBD1 Gene

neXtProt entry for TUBD1 Gene

Proteomics data for TUBD1 Gene at MOPED

Post-translational modifications for TUBD1 Gene

  • Ubiquitination at Lys 47 and Lys 79
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for TUBD1

No data available for DME Specific Peptides for TUBD1 Gene

Domains & Families for TUBD1 Gene

Gene Families for TUBD1 Gene

Protein Domains for TUBD1 Gene

Suggested Antigen Peptide Sequences for TUBD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJT1

UniProtKB/Swiss-Prot:

TBD_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBD1: view

Function for TUBD1 Gene

Molecular function for TUBD1 Gene

UniProtKB/Swiss-Prot Function:
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Gene Ontology (GO) - Molecular Function for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBD1: view
genes like me logo Genes that share phenotypes with TUBD1: view

miRNA for TUBD1 Gene

miRTarBase miRNAs that target TUBD1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBD1 Gene

Localization for TUBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBD1 Gene COMPARTMENTS Subcellular localization image for TUBD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005814 centriole IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Pathways & Interactions for TUBD1 Gene

genes like me logo Genes that share pathways with TUBD1: view

SIGNOR curated interactions for TUBD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Drugs & Compounds for TUBD1 Gene

(4) Drugs for TUBD1 Gene - From: Tocris and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 230
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 104
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0

(2) Additional Compounds for TUBD1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Vinblastine sulfate
143-67-9
Vincristine sulfate
2068-78-2

(5) Tocris Compounds for TUBD1 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Nocodazole Microtubule inhibitor 31430-18-9
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
Vincristine sulfate Disrupts microtubules 2068-78-2
genes like me logo Genes that share compounds with TUBD1: view

Transcripts for TUBD1 Gene

Unigene Clusters for TUBD1 Gene

Tubulin, delta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - -

Relevant External Links for TUBD1 Gene

GeneLoc Exon Structure for
TUBD1
ECgene alternative splicing isoforms for
TUBD1

Expression for TUBD1 Gene

mRNA expression in normal human tissues for TUBD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBD1 Gene



SOURCE GeneReport for Unigene cluster for TUBD1 Gene Hs.463638

genes like me logo Genes that share expression patterns with TUBD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TUBD1 Gene

Orthologs for TUBD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBD1 35
  • 90.14 (n)
  • 89.62 (a)
TUBD1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBD1 35
  • 91.02 (n)
  • 89.62 (a)
TUBD1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubd1 35
  • 84.33 (n)
  • 85.65 (a)
Tubd1 16
Tubd1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBD1 35
  • 99.78 (n)
  • 99.56 (a)
TUBD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubd1 35
  • 82.63 (n)
  • 84.55 (a)
oppossum
(Monodelphis domestica)
Mammalia TUBD1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBD1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBD1 35
  • 73.88 (n)
  • 75.06 (a)
TUBD1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBD1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12654 35
tubd1 35
  • 72.21 (n)
  • 70.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia tubd1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii tubd1 35
  • 62.78 (n)
  • 60.76 (a)
tubd1 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbg-1 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 36
  • 21 (a)
OneToMany
Species with no ortholog for TUBD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBD1 Gene

ENSEMBL:
Gene Tree for TUBD1 (if available)
TreeFam:
Gene Tree for TUBD1 (if available)

Paralogs for TUBD1 Gene

Paralogs for TUBD1 Gene

(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TUBD1: view

Variants for TUBD1 Gene

Sequence variations from dbSNP and Humsavar for TUBD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1292053 - 59,886,176(-) TCAAA(C/T)GCTGT intron-variant, reference, missense, utr-variant-5-prime
rs1292041 -- 59,860,680(-) GAACC(C/T)GGGAG intron-variant
rs1292045 -- 59,869,851(-) CTGTC(A/G)TGTGT intron-variant
rs1292046 -- 59,868,818(-) cgctc(C/T)gtcgc intron-variant
rs1292047 -- 59,877,805(-) AGTGT(A/G)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBD1 Gene

Variant ID Type Subtype PubMed ID
esv2716085 CNV Deletion 23290073

Variation tolerance for TUBD1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.32; 95.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBD1 Gene

HapMap Linkage Disequilibrium report
TUBD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene

Disorders for TUBD1 Gene

Relevant External Links for TUBD1

Genetic Association Database (GAD)
TUBD1
Human Genome Epidemiology (HuGE) Navigator
TUBD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBD1

No disorders were found for TUBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBD1 Gene

Publications for TUBD1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 23 67
  2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A. … Todokoro K. (Dev. Biol. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. (PMID: 23826228) He M. … Zhou J. (PLoS ONE 2013) 3
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for TUBD1 Gene

Sources for TUBD1 Gene

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