External Ids for TUBD1 Gene
GeneCards Summary for TUBD1 Gene
TUBD1 (Tubulin, Delta 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.
UniProtKB/Swiss-Prot for TUBD1 Gene
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.