Aliases for EGFL7 Gene
External Ids for EGFL7 Gene
Previous GeneCards Identifiers for EGFL7 Gene
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
GeneCards Summary for EGFL7 Gene
EGFL7 (EGF-Like-Domain, Multiple 7) is a Protein Coding gene. Diseases associated with EGFL7 include cenani-lenz syndactyly syndrome and sclerosteosis 2. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is EGFL8.
UniProtKB/Swiss-Prot for EGFL7 Gene
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.