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Aliases for EGFL7 Gene

Aliases for EGFL7 Gene

  • EGF-Like-Domain, Multiple 7 2 3
  • Multiple Epidermal Growth Factor-Like Domains Protein 7 3 4
  • Multiple EGF-Like Domains Protein 7 3 4
  • Vascular Endothelial Statin 3 4
  • NOTCH4-Like Protein 3 4
  • EGF-Like Protein 7 3 4
  • VE-STATIN 3 4
  • ZNEU1 3 4
  • Epidermal Growth Factor-Like Protein 7 3
  • MEGF7 4
  • NEU1 3

External Ids for EGFL7 Gene

Summaries for EGFL7 Gene

Entrez Gene Summary for EGFL7 Gene

  • This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for EGFL7 Gene

EGFL7 (EGF-Like-Domain, Multiple 7) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EGFL8.

UniProtKB/Swiss-Prot for EGFL7 Gene

  • Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Gene Wiki entry for EGFL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGFL7 Gene

Genomics for EGFL7 Gene

Genomic Location for EGFL7 Gene

136,658,856 bp from pter
136,672,678 bp from pter
13,823 bases
Plus strand

Genomic View for EGFL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGFL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGFL7 Gene

Regulatory Elements for EGFL7 Gene

Proteins for EGFL7 Gene

  • Protein details for EGFL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epidermal growth factor-like protein 7
    Protein Accession:
    Secondary Accessions:
    • B3KRP0
    • M9VTX9
    • Q5M7Y5
    • Q5VUD5
    • Q96EG0

    Protein attributes for EGFL7 Gene

    273 amino acids
    Molecular mass:
    29618 Da
    Quaternary structure:
    • Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cells motility.
    • Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization

neXtProt entry for EGFL7 Gene

Proteomics data for EGFL7 Gene at MOPED

Post-translational modifications for EGFL7 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr54, Thr55, and Thr190

Other Protein References for EGFL7 Gene

No data available for DME Specific Peptides for EGFL7 Gene

Domains for EGFL7 Gene


  • Contains 2 EGF-like domains.:
    • Q9UHF1
  • Contains 1 EMI domain.:
    • Q9UHF1
genes like me logo Genes that share domains with EGFL7: view

No data available for Gene Families for EGFL7 Gene

Function for EGFL7 Gene

Molecular function for EGFL7 Gene

UniProtKB/Swiss-Prot Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Gene Ontology (GO) - Molecular Function for EGFL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EGFL7: view
genes like me logo Genes that share phenotypes with EGFL7: view

Animal Models for EGFL7 Gene

MGI Knock Outs for EGFL7:

miRNA for EGFL7 Gene

miRTarBase miRNAs that target EGFL7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EGFL7 Gene

Localization for EGFL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGFL7 Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for EGFL7 Gene COMPARTMENTS Subcellular localization image for EGFL7 gene
Compartment Confidence
extracellular 4
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for EGFL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
GO:0031012 extracellular matrix IDA 23658023
genes like me logo Genes that share ontologies with EGFL7: view

Pathways for EGFL7 Gene

genes like me logo Genes that share pathways with EGFL7: view

Pathways by source for EGFL7 Gene

Gene Ontology (GO) - Biological Process for EGFL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development ISS --
GO:0001570 vasculogenesis ISS --
GO:0001938 positive regulation of endothelial cell proliferation IMP 20947685
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with EGFL7: view

Transcripts for EGFL7 Gene

Unigene Clusters for EGFL7 Gene

EGF-like-domain, multiple 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EGFL7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - - - -
SP13: - - - -

Relevant External Links for EGFL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EGFL7 Gene

mRNA expression in normal human tissues for EGFL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for EGFL7 Gene

SOURCE GeneReport for Unigene cluster for EGFL7 Gene Hs.91481

genes like me logo Genes that share expressions with EGFL7: view

Orthologs for EGFL7 Gene

This gene was present in the common ancestor of animals.

Orthologs for EGFL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EGFL7 36
  • 99.02 (n)
  • 99.27 (a)
EGFL7 37
  • 99 (a)
(Bos Taurus)
Mammalia EGFL7 36
  • 84.31 (n)
  • 80.15 (a)
EGFL7 37
  • 72 (a)
(Canis familiaris)
Mammalia EGFL7 36
  • 84.13 (n)
  • 81.18 (a)
EGFL7 37
  • 80 (a)
(Mus musculus)
Mammalia Egfl7 36
  • 78.43 (n)
  • 78.68 (a)
Egfl7 16
Egfl7 37
  • 77 (a)
(Monodelphis domestica)
Mammalia EGFL7 37
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia EGFL7 37
  • 60 (a)
(Gallus gallus)
Aves EGFL7 36
  • 61.78 (n)
  • 53.28 (a)
EGFL7 37
  • 50 (a)
(Anolis carolinensis)
Reptilia EGFL7 37
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia egfl7 36
  • 60.34 (n)
  • 52.71 (a)
(Danio rerio)
Actinopterygii egfl7 36
  • 52.2 (n)
  • 45.74 (a)
egfl7 37
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta slow 36
  • 45.72 (n)
  • 34.55 (a)
slow 37
  • 12 (a)
Species with no ortholog for EGFL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EGFL7 Gene

Gene Tree for EGFL7 (if available)
Gene Tree for EGFL7 (if available)

Paralogs for EGFL7 Gene

Paralogs for EGFL7 Gene

Selected SIMAP similar genes for EGFL7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EGFL7: view

Variants for EGFL7 Gene

Sequence variations from dbSNP and Humsavar for EGFL7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1051828 -- 136,672,371(+) CAGAA(A/G)CCACC utr-variant-3-prime, nc-transcript-variant
rs1051851 -- 136,672,544(+) GGTGG(A/G)CCCTC utr-variant-3-prime, nc-transcript-variant
rs3192237 -- 136,672,476(+) GGGAT(C/T)TTCTC utr-variant-3-prime, nc-transcript-variant
rs3793658 -- 136,667,487(-) GGGCC(C/T)GGGTG intron-variant
rs3793659 -- 136,667,383(-) CCTGG(C/T)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EGFL7 Gene

Variant ID Type Subtype PubMed ID
dgv8385n71 CNV Loss 21882294
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
dgv8396n71 CNV Loss 21882294
dgv8400n71 CNV Loss 21882294
nsv894386 CNV Loss 21882294
nsv894387 CNV Gain 21882294
nsv8579 CNV Gain 18304495
dgv8401n71 CNV Loss 21882294
nsv509334 CNV Insertion 20534489
dgv8404n71 CNV Loss 21882294
dgv2427e1 CNV Complex 17122850
dgv955n27 CNV Loss 19166990
esv2422220 CNV Deletion 17116639
dgv8407n71 CNV Loss 21882294
dgv8408n71 CNV Loss 21882294
nsv894415 CNV Gain 21882294
nsv894429 CNV Loss 21882294
dgv957n27 CNV Loss 19166990
nsv894430 CNV Loss 21882294
dgv8410n71 CNV Loss 21882294
nsv894433 CNV Loss 21882294
nsv894434 CNV Loss 21882294
dgv8411n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
esv32979 CNV Gain 17666407
nsv894446 CNV Loss 21882294

Relevant External Links for EGFL7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for EGFL7 Gene

Relevant External Links for EGFL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EGFL7: view

No data available for UniProtKB/Swiss-Prot for EGFL7 Gene

Publications for EGFL7 Gene

  1. VE-statin, an endothelial repressor of smooth muscle cell migration. (PMID: 14592969) Soncin F. … Stehelin D. (EMBO J. 2003) 3 23
  2. Epidermal growth factor-like domain 7 protects endothelial cells from hyperoxia-induced cell death. (PMID: 17934064) Xu D. … Truog W.E. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008) 3 23
  3. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. (PMID: 19503073) Schmidt M.H. … Dikic I. (Nat. Cell Biol. 2009) 3 23
  4. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. (PMID: 19824075) Wu F. … Fan C. (Hepatology 2009) 3 23
  5. miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7. (PMID: 20034472) Sun Y. … Guo L. (Biochem. Biophys. Res. Commun. 2010) 3 23

Products for EGFL7 Gene

  • antibodies-online proteins for EGFL7
  • antibodies-online antibodies for EGFL7
  • antibodies-online kits for EGFL7

Sources for EGFL7 Gene

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