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Aliases for ADIPOR1 Gene

Aliases for ADIPOR1 Gene

  • Adiponectin Receptor 1 2 3
  • Progestin And AdipoQ Receptor Family Member I 3 4
  • TESBP1A 3 4
  • CGI45 3 6
  • PAQR1 3 4
  • Adiponectin Receptor Protein 1 3
  • ACDCR1 3
  • CGI-45 3

External Ids for ADIPOR1 Gene

Summaries for ADIPOR1 Gene

Entrez Gene Summary for ADIPOR1 Gene

  • This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADIPOR1 Gene

ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include nonalcoholic steatohepatitis and obesity. Among its related pathways are Adipocytokine signaling pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.

UniProtKB/Swiss-Prot for ADIPOR1 Gene

  • Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.

Gene Wiki entry for ADIPOR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOR1 Gene

Genomics for ADIPOR1 Gene

Genomic Location for ADIPOR1 Gene

Start:
202,940,823 bp from pter
End:
202,958,572 bp from pter
Size:
17,750 bases
Orientation:
Minus strand

Genomic View for ADIPOR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADIPOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOR1 Gene

Regulatory Elements for ADIPOR1 Gene

Proteins for ADIPOR1 Gene

  • Protein details for ADIPOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A54-ADR1_HUMAN
    Recommended name:
    Adiponectin receptor protein 1
    Protein Accession:
    Q96A54
    Secondary Accessions:
    • B3KMB0
    • Q53HS7
    • Q53YY6
    • Q9Y360

    Protein attributes for ADIPOR1 Gene

    Size:
    375 amino acids
    Molecular mass:
    42616 Da
    Quaternary structure:
    • May form homomultimer and heteromultimers.
    SequenceCaution:
    • Sequence=AAD34040.1; Type=Frameshift; Positions=369; Evidence={ECO:0000305};

neXtProt entry for ADIPOR1 Gene

Proteomics data for ADIPOR1 Gene at MOPED

Post-translational modifications for ADIPOR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys86

Other Protein References for ADIPOR1 Gene

No data available for DME Specific Peptides for ADIPOR1 Gene

Domains for ADIPOR1 Gene

Gene Families for ADIPOR1 Gene

HGNC:
  • ADIPOR :GPCR / Unclassified : Adiponectin receptors
IUPHAR :

Protein Domains for ADIPOR1 Gene

UniProtKB/Swiss-Prot:

ADR1_HUMAN
Domain:
  • The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular:
    • Q96A54
Family:
  • Belongs to the ADIPOR family.:
    • Q96A54
genes like me logo Genes that share domains with ADIPOR1: view

Function for ADIPOR1 Gene

Molecular function for ADIPOR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.

Gene Ontology (GO) - Molecular Function for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005515 protein binding --
GO:0019901 protein kinase binding IPI 19233263
GO:0042562 hormone binding IDA 12802337
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with ADIPOR1: view
genes like me logo Genes that share phenotypes with ADIPOR1: view

Animal Models for ADIPOR1 Gene

MGI Knock Outs for ADIPOR1:

miRNA for ADIPOR1 Gene

miRTarBase miRNAs that target ADIPOR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADIPOR1 Gene

Localization for ADIPOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOR1 Gene

Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOR1 Gene COMPARTMENTS Subcellular localization image for ADIPOR1 gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 19233263
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane NAS 12802337
genes like me logo Genes that share ontologies with ADIPOR1: view

Pathways for ADIPOR1 Gene

genes like me logo Genes that share pathways with ADIPOR1: view

Pathways by source for ADIPOR1 Gene

1 BioSystems pathway for ADIPOR1 Gene

Gene Ontology (GO) - Biological Process for ADIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009755 hormone-mediated signaling pathway IDA 12802337
GO:0019395 fatty acid oxidation IDA 12802337
GO:0030308 negative regulation of cell growth IEA --
GO:0033210 leptin-mediated signaling pathway IEA --
GO:0033211 adiponectin-activated signaling pathway IBA --
genes like me logo Genes that share ontologies with ADIPOR1: view

Compounds for ADIPOR1 Gene

(12) Novoseek inferred chemical compound relationships for ADIPOR1 Gene

Compound -log(P) Hits PubMed IDs
glucose 52.6 19
fatty acid 50.4 9
pioglitazone 43.5 2
c-peptide 42.8 1
lipid 33.5 6
genes like me logo Genes that share compounds with ADIPOR1: view

Transcripts for ADIPOR1 Gene

Unigene Clusters for ADIPOR1 Gene

Adiponectin receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: - - -
SP11:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ADIPOR1 Gene

GeneLoc Exon Structure for
ADIPOR1
ECgene alternative splicing isoforms for
ADIPOR1

Expression for ADIPOR1 Gene

mRNA expression in normal human tissues for ADIPOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADIPOR1 Gene

This gene is overexpressed in Whole Blood (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADIPOR1 Gene

SOURCE GeneReport for Unigene cluster for ADIPOR1 Gene Hs.713729

mRNA Expression by UniProt/SwissProt for ADIPOR1 Gene

Q96A54-ADR1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
genes like me logo Genes that share expressions with ADIPOR1: view

Orthologs for ADIPOR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADIPOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOR1 36
  • 99.56 (n)
  • 100 (a)
ADIPOR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADIPOR1 36
  • 87.64 (n)
  • 96.8 (a)
ADIPOR1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIPOR1 36
  • 95.47 (n)
  • 98.93 (a)
ADIPOR1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adipor1 36
  • 90.93 (n)
  • 96.8 (a)
Adipor1 16
Adipor1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIPOR1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOR1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adipor1 36
  • 91.82 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves ADIPOR1 36
  • 80.12 (n)
  • 91.44 (a)
ADIPOR1 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADIPOR1 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia adipor1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia adipor1 36
  • 76.64 (n)
  • 89.2 (a)
Str.15110 36
zebrafish
(Danio rerio)
Actinopterygii adipor1a 37
  • 82 (a)
OneToMany
adipor1b 36
  • 73.2 (n)
  • 82.91 (a)
adipor1b 37
  • 79 (a)
OneToMany
Dr.4053 36
fruit fly
(Drosophila melanogaster)
Insecta CG5315 36
  • 58.38 (n)
  • 56.67 (a)
CG5315 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea paqr-1 36
  • 58.73 (n)
  • 57.14 (a)
paqr-1 37
  • 40 (a)
ManyToMany
paqr-2 37
  • 29 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL002C 36
  • 45.91 (n)
  • 38.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IZH1 37
  • 30 (a)
ManyToMany
IZH2 36
  • 44.9 (n)
  • 37.31 (a)
IZH2 37
  • 34 (a)
ManyToMany
IZH3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01331g 36
  • 45.05 (n)
  • 38.22 (a)
rice
(Oryza sativa)
Liliopsida Os12g0511200 36
  • 48.44 (n)
  • 39.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04987 36
  • 47.33 (n)
  • 38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.09c 36
  • 47.88 (n)
  • 41.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4089 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8140 37
  • 51 (a)
OneToMany
Species with no ortholog for ADIPOR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADIPOR1 Gene

ENSEMBL:
Gene Tree for ADIPOR1 (if available)
TreeFam:
Gene Tree for ADIPOR1 (if available)

Paralogs for ADIPOR1 Gene

Paralogs for ADIPOR1 Gene

Selected SIMAP similar genes for ADIPOR1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADIPOR1 Gene

genes like me logo Genes that share paralogs with ADIPOR1: view

Variants for ADIPOR1 Gene

Sequence variations from dbSNP and Humsavar for ADIPOR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8167 -- 202,941,059(-) AAGCC(A/C)CCAAC utr-variant-3-prime, nc-transcript-variant
rs10581 -- 202,941,190(-) ACCCC(C/T)ATCCT utr-variant-3-prime, nc-transcript-variant
rs1043213 -- 202,946,476(-) CGCAT(C/T)CATAC synonymous-codon, reference, nc-transcript-variant
rs1043268 -- 202,941,138(-) AGCAC(A/C)CTTTT utr-variant-3-prime, nc-transcript-variant
rs1043280 -- 202,941,100(-) TCTTT(C/T)TAGGG utr-variant-3-prime, nc-transcript-variant

Relevant External Links for ADIPOR1 Gene

HapMap Linkage Disequilibrium report
ADIPOR1
Human Gene Mutation Database (HGMD)
ADIPOR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADIPOR1 Gene

Disorders for ADIPOR1 Gene

(1) University of Copenhagen DISEASES for ADIPOR1 Gene

(13) Novoseek inferred disease relationships for ADIPOR1 Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 74.8 15
insulin resistance 74.3 31
obesity 64.4 12
impaired glucose tolerance 40.8 3
diabetes gestational 37.8 2

Relevant External Links for ADIPOR1

Genetic Association Database (GAD)
ADIPOR1
Human Genome Epidemiology (HuGE) Navigator
ADIPOR1
genes like me logo Genes that share disorders with ADIPOR1: view

No data available for UniProtKB/Swiss-Prot for ADIPOR1 Gene

Publications for ADIPOR1 Gene

  1. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. (PMID: 15918014) Hara K. … Kadowaki T. (Diabetologia 2005) 3 23 49
  2. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. (PMID: 15983228) Damcott C.M. … Shuldiner A.R. (Diabetes 2005) 3 23 49
  3. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. (PMID: 16205883) Stefan N. … HAoring H.U. (Diabetologia 2005) 3 23 49
  4. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (PMID: 16505255) Vaxillaire M. … Froguel P. (Diabetes 2006) 3 23 49
  5. Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. (PMID: 16700915) Broedl U.C. … Parhofer K.G. (Cardiovasc Diabetol 2006) 3 23 49

Products for ADIPOR1 Gene

Sources for ADIPOR1 Gene

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