Aliases for ADIPOR1 Gene
External Ids for ADIPOR1 Gene
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
GeneCards Summary for ADIPOR1 Gene
ADIPOR1 (Adiponectin Receptor 1) is a Protein Coding gene. Diseases associated with ADIPOR1 include nonalcoholic steatohepatitis and obesity. Among its related pathways are Adipocytokine signaling pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is ADIPOR2.
UniProtKB/Swiss-Prot for ADIPOR1 Gene
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.