Aliases for GAL Gene
External Ids for GAL Gene
Previous Symbols for GAL Gene
Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009]
GeneCards Summary for GAL Gene
GAL (Galanin/GMAP Prepropeptide) is a Protein Coding gene. Diseases associated with GAL include normal pressure hydrocephalus and pain disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity.
UniProtKB/Swiss-Prot for GAL Gene
Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal tract. Galanin receptors mediate a variety of physiological functions including inhibition of glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions, suggesting a role in the development and/or pathology of certain diseases. These include Alzheimers disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.