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Aliases for FCF1 Gene

Aliases for FCF1 Gene

  • FCF1 RRNA-Processing Protein 2 3
  • C14orf111 3 4
  • FCF1 Small Subunit (SSU) Processome Component Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 111 2
  • RRNA-Processing Protein FCF1 Homolog 3
  • FCF1 Small Subunit 3
  • CGI-35 3
  • UTP24 3
  • Bka 3

External Ids for FCF1 Gene

Previous HGNC Symbols for FCF1 Gene

  • C14orf111

Previous GeneCards Identifiers for FCF1 Gene

  • GC14P074250
  • GC14P075179

Summaries for FCF1 Gene

GeneCards Summary for FCF1 Gene

FCF1 (FCF1 RRNA-Processing Protein) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for FCF1 Gene

  • Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Wiki entry for FCF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCF1 Gene

Genomics for FCF1 Gene

Regulatory Elements for FCF1 Gene

Genomic Location for FCF1 Gene

Start:
74,713,115 bp from pter
End:
74,738,620 bp from pter
Size:
25,506 bases
Orientation:
Plus strand

Genomic View for FCF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCF1 Gene

Proteins for FCF1 Gene

  • Protein details for FCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y324-FCF1_HUMAN
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Protein Accession:
    Q9Y324
    Secondary Accessions:
    • Q86TW8
    • Q8TBL8

    Protein attributes for FCF1 Gene

    Size:
    198 amino acids
    Molecular mass:
    23370 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FCF1 Gene

Proteomics data for FCF1 Gene at MOPED

Post-translational modifications for FCF1 Gene

  • Ubiquitination at Lys137
  • Modification sites at PhosphoSitePlus

Other Protein References for FCF1 Gene

No data available for DME Specific Peptides for FCF1 Gene

Domains for FCF1 Gene

Protein Domains for FCF1 Gene

Suggested Antigen Peptide Sequences for FCF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y324

UniProtKB/Swiss-Prot:

FCF1_HUMAN :
  • Q9Y324
Domain:
  • Contains 1 PINc domain.
Family:
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
genes like me logo Genes that share domains with FCF1: view

No data available for Gene Families for FCF1 Gene

Function for FCF1 Gene

Molecular function for FCF1 Gene

UniProtKB/Swiss-Prot Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Ontology (GO) - Molecular Function for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FCF1: view

Phenotypes for FCF1 Gene

genes like me logo Genes that share phenotypes with FCF1: view

miRNA for FCF1 Gene

miRTarBase miRNAs that target FCF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FCF1 Gene

Localization for FCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCF1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FCF1 Gene COMPARTMENTS Subcellular localization image for FCF1 gene
Compartment Confidence
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with FCF1: view

Pathways for FCF1 Gene

genes like me logo Genes that share pathways with FCF1: view

Pathways by source for FCF1 Gene

1 KEGG pathway for FCF1 Gene

Gene Ontology (GO) - Biological Process for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
genes like me logo Genes that share ontologies with FCF1: view

Transcripts for FCF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FCF1 Gene

No ASD Table

Relevant External Links for FCF1 Gene

GeneLoc Exon Structure for
FCF1
ECgene alternative splicing isoforms for
FCF1

Expression for FCF1 Gene

mRNA expression in normal human tissues for FCF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FCF1 Gene

SOURCE GeneReport for Unigene cluster for FCF1 Gene Hs.579828

genes like me logo Genes that share expressions with FCF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FCF1 Gene

Orthologs for FCF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FCF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCF1 35
  • 99.66 (n)
  • 100 (a)
FCF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCF1 35
  • 94.61 (n)
  • 100 (a)
FCF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
FCF1 35
  • 94.11 (n)
  • 99.49 (a)
mouse
(Mus musculus)
Mammalia Fcf1 35
  • 89.39 (n)
  • 97.98 (a)
Fcf1 16
Fcf1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCF1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FCF1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcf1 35
  • 90.07 (n)
  • 98.48 (a)
chicken
(Gallus gallus)
Aves FCF1 35
  • 78.45 (n)
  • 90.91 (a)
FCF1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FCF1 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20881 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fcf1 35
  • 76.99 (n)
  • 87.82 (a)
Str.1834 35
zebrafish
(Danio rerio)
Actinopterygii fcf1 35
  • 76.43 (n)
  • 88.38 (a)
FCF1 36
  • 76 (a)
OneToOne
wufc51c12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009504 35
  • 60.91 (n)
  • 67.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bka 35
  • 65.28 (n)
  • 70.47 (a)
Bka 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F30A10.9 35
  • 61.31 (n)
  • 59.59 (a)
F30A10.9 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL102W 35
  • 59.22 (n)
  • 62.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF1 35
  • 60.82 (n)
  • 63.3 (a)
FCF1 36
  • 62 (a)
OneToOne
FCF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07018g 35
  • 59.04 (n)
  • 60.64 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2007 35
soybean
(Glycine max)
eudicotyledons Gma.13234 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46230 35
  • 65.81 (n)
  • 68.04 (a)
corn
(Zea mays)
Liliopsida Zm.10381 35
rice
(Oryza sativa)
Liliopsida Os.33206 35
Os06g0158600 35
  • 64.29 (n)
  • 69.39 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9069 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04159 35
  • 55.37 (n)
  • 57.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC32H8.04c 35
  • 61.38 (n)
  • 64.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4808 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6957 36
  • 76 (a)
OneToOne
Species with no ortholog for FCF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FCF1 Gene

ENSEMBL:
Gene Tree for FCF1 (if available)
TreeFam:
Gene Tree for FCF1 (if available)

Paralogs for FCF1 Gene

Selected SIMAP similar genes for FCF1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FCF1: view

No data available for Paralogs for FCF1 Gene

Variants for FCF1 Gene

Sequence variations from dbSNP and Humsavar for FCF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1057500 -- 74,738,413(+) TTGAA(A/G)AGTTT nc-transcript-variant
rs2111703 -- 74,737,812(+) ACCCC(A/G)TCTCT nc-transcript-variant
rs2287400 -- 74,716,234(+) TAGCA(A/G)TGACC intron-variant
rs2302833 -- 74,734,268(+) GAAAT(C/T)ATTGT intron-variant
rs3214408 -- 74,734,369(+) CATTT(-/A)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FCF1 Gene

Variant ID Type Subtype PubMed ID
nsv832831 CNV Loss 17160897
nsv832832 CNV Gain+Loss 17160897

Relevant External Links for FCF1 Gene

HapMap Linkage Disequilibrium report
FCF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCF1 Gene

Disorders for FCF1 Gene

No disorders were found for FCF1 Gene.

No data available for UniProtKB/Swiss-Prot for FCF1 Gene

Publications for FCF1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PMID: 16762320) Rempola B. … Rytka J. (Biochem. Biophys. Res. Commun. 2006) 2 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3

Products for FCF1 Gene

Sources for FCF1 Gene

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