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Aliases for PRLH Gene

Aliases for PRLH Gene

  • Prolactin Releasing Hormone 2 3
  • Prolactin-Releasing Hormone 3 4
  • PRRP 3 4
  • PRH 3 4
  • Preproprolactin-Releasing Peptide 3

External Ids for PRLH Gene

Previous GeneCards Identifiers for PRLH Gene

  • GC02P238762
  • GC02P238257
  • GC02P238139
  • GC02P238475
  • GC02P230265

Summaries for PRLH Gene

GeneCards Summary for PRLH Gene

PRLH (Prolactin Releasing Hormone) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and prolactin-releasing peptide receptor binding.

UniProtKB/Swiss-Prot for PRLH Gene

  • Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL

Gene Wiki entry for PRLH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLH Gene

Genomics for PRLH Gene

Regulatory Elements for PRLH Gene

Genomic Location for PRLH Gene

Chromosome:
2
Start:
237,566,574 bp from pter
End:
237,567,175 bp from pter
Size:
602 bases
Orientation:
Plus strand

Genomic View for PRLH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRLH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLH Gene

Proteins for PRLH Gene

  • Protein details for PRLH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81277-PRRP_HUMAN
    Recommended name:
    Prolactin-releasing peptide
    Protein Accession:
    P81277

    Protein attributes for PRLH Gene

    Size:
    87 amino acids
    Molecular mass:
    9639 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRLH Gene

Proteomics data for PRLH Gene at MOPED

Post-translational modifications for PRLH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRLH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLH Gene

Domains & Families for PRLH Gene

Gene Families for PRLH Gene

Protein Domains for PRLH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRLH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRLH: view

No data available for UniProtKB/Swiss-Prot for PRLH Gene

Function for PRLH Gene

Molecular function for PRLH Gene

UniProtKB/Swiss-Prot Function:
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL

Gene Ontology (GO) - Molecular Function for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 9607765
GO:0005184 neuropeptide hormone activity IEA --
GO:0031861 prolactin-releasing peptide receptor binding IEA --
genes like me logo Genes that share ontologies with PRLH: view
genes like me logo Genes that share phenotypes with PRLH: view

Animal Models for PRLH Gene

MGI Knock Outs for PRLH:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRLH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PRLH Gene

Localization for PRLH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRLH Gene COMPARTMENTS Subcellular localization image for PRLH gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PRLH: view

Pathways & Interactions for PRLH Gene

genes like me logo Genes that share pathways with PRLH: view

Interacting Proteins for PRLH Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000165524%0d%0a9606.ENSP00000239032%0d%0a9606.ENSP00000309953%0d%0a9606.ENSP00000203001%0d%0a
Selected Interacting proteins: P81277-PRRP_HUMAN ENSP00000165524 for PRLH Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IEA --
GO:0002021 response to dietary excess --
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006112 energy reserve metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PRLH: view

No data available for SIGNOR curated interactions for PRLH Gene

Drugs & Compounds for PRLH Gene

(5) Drugs for PRLH Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Norepinephrine Approved Pharma 206
ACTH Pharma 0
arginine Nutra 346
Calcium Nutra 0
tyrosine Nutra 547

(2) Additional Compounds for PRLH Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NPFF
Rfamide
genes like me logo Genes that share compounds with PRLH: view

Transcripts for PRLH Gene

mRNA/cDNA for PRLH Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRLH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLH Gene

No ASD Table

Relevant External Links for PRLH Gene

GeneLoc Exon Structure for
PRLH
ECgene alternative splicing isoforms for
PRLH

Expression for PRLH Gene

mRNA expression in normal human tissues for PRLH Gene

mRNA differential expression in normal tissues according to GTEx for PRLH Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x33.9) and Heart - Atrial Appendage (x7.0).

SOURCE GeneReport for Unigene cluster for PRLH Gene Hs.247710

mRNA Expression by UniProt/SwissProt for PRLH Gene

P81277-PRRP_HUMAN
Tissue specificity: Medulla oblongata and hypothalamus.
genes like me logo Genes that share expression patterns with PRLH: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRLH Gene

Orthologs for PRLH Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRLH Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Prlh 35
  • 79.67 (n)
  • 73.17 (a)
Prlh 16
Prlh 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prlh 35
  • 74.9 (n)
  • 67.9 (a)
cow
(Bos Taurus)
Mammalia PRLH 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRLH 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRLH 36
  • 53 (a)
OneToOne
Species with no ortholog for PRLH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRLH Gene

ENSEMBL:
Gene Tree for PRLH (if available)
TreeFam:
Gene Tree for PRLH (if available)

Paralogs for PRLH Gene

(1) SIMAP similar genes for PRLH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRLH: view

No data available for Paralogs for PRLH Gene

Variants for PRLH Gene

Sequence variations from dbSNP and Humsavar for PRLH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2280287 -- 237,567,430(-) GGTAG(A/T)CCCAG downstream-variant-500B
rs10207646 -- 237,564,798(+) CTGGG(A/C)TGGCA upstream-variant-2KB
rs11886054 -- 237,567,538(+) ATACT(C/G)TGCAG downstream-variant-500B
rs11896561 -- 237,567,530(+) CACGC(A/G)TCATA downstream-variant-500B
rs12988983 -- 237,566,142(+) ACACA(C/G)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRLH Gene

Variant ID Type Subtype PubMed ID
nsv876054 CNV Gain 21882294

Variation tolerance for PRLH Gene

Residual Variation Intolerance Score: 59.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRLH Gene

HapMap Linkage Disequilibrium report
PRLH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLH Gene

Disorders for PRLH Gene

Relevant External Links for PRLH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRLH
genes like me logo Genes that share disorders with PRLH: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLH Gene

Publications for PRLH Gene

  1. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S. … Fujino M. (Nature 1998) 2 23 67
  2. Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone. (PMID: 19500229) Yamada T. … Inoue K. (J. Neuroendocrinol. 2009) 23 67
  3. Prolactin-releasing peptide, a possible modulator of prolactin in the euryhaline silver sea bream (Sparus sarba): A molecular study. (PMID: 18640118) Kwong A.K. … Woo N.Y. (Gen. Comp. Endocrinol. 2008) 23 67
  4. Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress. (PMID: 16917019) Ohiwa N. … Soya H. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007) 23 67
  5. Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. (PMID: 16500002) Fukusumi S. … Hinuma S. (Peptides 2006) 23 67

Products for PRLH Gene

Sources for PRLH Gene

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