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Aliases for ZBTB7B Gene

Aliases for ZBTB7B Gene

  • Zinc Finger And BTB Domain Containing 7B 2 3
  • Krueppel-Related Zinc Finger Protein CKrox 3 4
  • T-Helper-Inducing POZ/Krueppel-Like Factor 3 4
  • Zinc Finger And BTB Domain Containing 15 2 3
  • Zinc Finger Protein 67 Homolog 3 4
  • Zinc Finger Protein Th-POK 3 4
  • Zinc Finger Protein 857B 3 4
  • ZNF857B 3 4
  • ZFP-67 3 4
  • HcKROX 3 4
  • ZBTB15 3 4
  • ZFP67 3 4
  • Zinc Finger And BTB Domain-Containing Protein 7B 3
  • Zinc Finger And BTB Domain-Containing Protein 15 4
  • Zinc Finger Protein 67 Homolog (Mouse) 2
  • C-KROX 3
  • CKROX 3
  • THPOK 3

External Ids for ZBTB7B Gene

Previous Symbols for ZBTB7B Gene

  • ZFP67

Summaries for ZBTB7B Gene

Entrez Gene Summary for ZBTB7B Gene

  • This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ZBTB7B Gene

ZBTB7B (Zinc Finger And BTB Domain Containing 7B) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is ZBTB4.

UniProtKB/Swiss-Prot for ZBTB7B Gene

  • Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).

Gene Wiki entry for ZBTB7B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB7B Gene

Genomics for ZBTB7B Gene

Genomic Location for ZBTB7B Gene

Start:
155,002,627 bp from pter
End:
155,018,525 bp from pter
Size:
15,899 bases
Orientation:
Plus strand

Genomic View for ZBTB7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB7B Gene

Regulatory Elements for ZBTB7B Gene

Proteins for ZBTB7B Gene

  • Protein details for ZBTB7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15156-ZBT7B_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 7B
    Protein Accession:
    O15156
    Secondary Accessions:
    • B4E3K5
    • D3DV83
    • J3KQQ3
    • Q68DR2
    • Q96EP2

    Protein attributes for ZBTB7B Gene

    Size:
    539 amino acids
    Molecular mass:
    58027 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH18158.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB7B Gene

Proteomics data for ZBTB7B Gene at MOPED

Post-translational modifications for ZBTB7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB7B Gene

No data available for DME Specific Peptides for ZBTB7B Gene

Domains for ZBTB7B Gene

Gene Families for ZBTB7B Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

UniProtKB/Swiss-Prot:

ZBT7B_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • O15156
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • O15156
genes like me logo Genes that share domains with ZBTB7B: view

Function for ZBTB7B Gene

Molecular function for ZBTB7B Gene

UniProtKB/Swiss-Prot Function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).

Gene Ontology (GO) - Molecular Function for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB7B: view
genes like me logo Genes that share phenotypes with ZBTB7B: view

Animal Models for ZBTB7B Gene

MGI Knock Outs for ZBTB7B:

miRNA for ZBTB7B Gene

miRTarBase miRNAs that target ZBTB7B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZBTB7B Gene

Localization for ZBTB7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB7B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB7B Gene COMPARTMENTS Subcellular localization image for ZBTB7B gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB7B: view

Pathways for ZBTB7B Gene

SuperPathways for ZBTB7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7937772
GO:0007275 multicellular organismal development IEA --
GO:0007398 ectoderm development TAS 7937772
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZBTB7B: view

No data available for Pathways by source for ZBTB7B Gene

Transcripts for ZBTB7B Gene

Unigene Clusters for ZBTB7B Gene

Zinc finger and BTB domain containing 7B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB7B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - - -
SP7:
SP8:
SP9: - - - -

Relevant External Links for ZBTB7B Gene

GeneLoc Exon Structure for
ZBTB7B
ECgene alternative splicing isoforms for
ZBTB7B

Expression for ZBTB7B Gene

mRNA expression in normal human tissues for ZBTB7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB7B Gene

This gene is overexpressed in Whole Blood (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB7B Gene

SOURCE GeneReport for Unigene cluster for ZBTB7B Gene Hs.729279

genes like me logo Genes that share expressions with ZBTB7B: view

Orthologs for ZBTB7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB7B 36
  • 99.71 (n)
  • 100 (a)
ZBTB7B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB7B 36
  • 89.16 (n)
  • 94.95 (a)
ZBTB7B 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB7B 36
  • 88.93 (n)
  • 94.99 (a)
ZBTB7B 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm18856 37
  • 85 (a)
OneToMany
Zbtb7b 36
  • 87.82 (n)
  • 91.84 (a)
Zbtb7b 16
Zbtb7b 37
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZBTB7B 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb7b 36
  • 86.97 (n)
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia cpg-A 36
zebrafish
(Danio rerio)
Actinopterygii ZBTB7B 37
  • 47 (a)
OneToOne
zgc63489 36
Species with no ortholog for ZBTB7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB7B Gene

ENSEMBL:
Gene Tree for ZBTB7B (if available)
TreeFam:
Gene Tree for ZBTB7B (if available)

Paralogs for ZBTB7B Gene

Paralogs for ZBTB7B Gene

Selected SIMAP similar genes for ZBTB7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB7B: view

Variants for ZBTB7B Gene

Sequence variations from dbSNP and Humsavar for ZBTB7B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1870940 -- 155,011,887(+) GTCTA(A/G)GAGGG intron-variant, upstream-variant-2KB
rs2242195 -- 155,016,481(-) GGTGG(C/T)GGGTA reference, synonymous-codon, nc-transcript-variant
rs3753639 -- 155,013,615(-) CTCCA(A/G)GGCCC intron-variant, upstream-variant-2KB
rs3820225 -- 155,014,317(-) TTCAT(A/G)GAGGT intron-variant
rs4845402 -- 155,005,453(+) TGGAG(A/G)AGGTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB7B Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294
nsv824775 CNV Loss 20364138

Relevant External Links for ZBTB7B Gene

HapMap Linkage Disequilibrium report
ZBTB7B

Disorders for ZBTB7B Gene

Relevant External Links for ZBTB7B

Genetic Association Database (GAD)
ZBTB7B
Human Genome Epidemiology (HuGE) Navigator
ZBTB7B
genes like me logo Genes that share disorders with ZBTB7B: view

No data available for UniProtKB/Swiss-Prot for ZBTB7B Gene

Publications for ZBTB7B Gene

  1. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. (PMID: 9370309) Widom R.L. … Korn J.H. (Gene 1997) 2 3 4
  2. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. (PMID: 17698844) Kypriotou M. … GalAcra P. (J. Biol. Chem. 2007) 3 23
  3. Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1. (PMID: 18298657) Renard E. … GalAcra P. (J. Cell. Mol. Med. 2008) 3 23
  4. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. (PMID: 19696430) Wang L. … Bosselut R. (J. Immunol. 2009) 3 23
  5. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. (PMID: 7937772) GalAcra P. … Karsenty G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3

Products for ZBTB7B Gene

Sources for ZBTB7B Gene

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