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Aliases for ZNF593 Gene

Aliases for ZNF593 Gene

  • Zinc Finger Protein 593 2 3
  • Zinc Finger Protein T86 3 4
  • ZT86 3

External Ids for ZNF593 Gene

Summaries for ZNF593 Gene

GeneCards Summary for ZNF593 Gene

ZNF593 (Zinc Finger Protein 593) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for ZNF593 Gene

  • Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins

Gene Wiki entry for ZNF593 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF593 Gene

Genomics for ZNF593 Gene

Genomic Location for ZNF593 Gene

Start:
26,169,871 bp from pter
End:
26,172,060 bp from pter
Size:
2,190 bases
Orientation:
Plus strand

Genomic View for ZNF593 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF593 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF593 Gene

Regulatory Elements for ZNF593 Gene

Proteins for ZNF593 Gene

  • Protein details for ZNF593 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00488-ZN593_HUMAN
    Recommended name:
    Zinc finger protein 593
    Protein Accession:
    O00488
    Secondary Accessions:
    • B2R4S0
    • Q5T2H7

    Protein attributes for ZNF593 Gene

    Size:
    134 amino acids
    Molecular mass:
    15199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02580.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH19267.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20369.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG34867.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF593 Gene

neXtProt entry for ZNF593 Gene

Proteomics data for ZNF593 Gene at MOPED

Post-translational modifications for ZNF593 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF593 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF593 Gene

Domains for ZNF593 Gene

Protein Domains for ZNF593 Gene

Suggested Antigen Peptide Sequences for ZNF593 Gene

Graphical View of Domain Structure for InterPro Entry

O00488

UniProtKB/Swiss-Prot:

ZN593_HUMAN
Domain:
  • The protein is largely disordered, with the exception of the zinc finger domain.:
    • O00488
Family:
  • Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.:
    • O00488
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • O00488
genes like me logo Genes that share domains with ZNF593: view

No data available for Gene Families for ZNF593 Gene

Function for ZNF593 Gene

Molecular function for ZNF593 Gene

UniProtKB/Swiss-Prot Function: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins

Gene Ontology (GO) - Molecular Function for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity TAS 9115366
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with ZNF593: view

Phenotypes for ZNF593 Gene

GenomeRNAi human phenotypes for ZNF593:
genes like me logo Genes that share phenotypes with ZNF593: view

miRNA for ZNF593 Gene

miRTarBase miRNAs that target ZNF593

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF593 Gene

Localization for ZNF593 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF593 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF593 Gene COMPARTMENTS Subcellular localization image for ZNF593 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF593: view

Pathways for ZNF593 Gene

SuperPathways for ZNF593 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF593 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9115366
GO:0006351 transcription, DNA-templated IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with ZNF593: view

No data available for Pathways by source for ZNF593 Gene

Transcripts for ZNF593 Gene

mRNA/cDNA for ZNF593 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF593 Gene

Zinc finger protein 593:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF593 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF593 Gene

GeneLoc Exon Structure for
ZNF593
ECgene alternative splicing isoforms for
ZNF593

Expression for ZNF593 Gene

mRNA expression in normal human tissues for ZNF593 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF593 Gene

SOURCE GeneReport for Unigene cluster for ZNF593 Gene Hs.477273

mRNA Expression by UniProt/SwissProt for ZNF593 Gene

O00488-ZN593_HUMAN
Tissue specificity: Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes
genes like me logo Genes that share expressions with ZNF593: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF593 Gene

Orthologs for ZNF593 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF593 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF593 35
  • 99.75 (n)
  • 100 (a)
ZNF593 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF593 35
  • 88.56 (n)
  • 93.28 (a)
ZNF593 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF593 35
  • 87.22 (n)
  • 87.97 (a)
ZNF593 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp593 35
  • 86.07 (n)
  • 90.3 (a)
Zfp593 16
Zfp593 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF593 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp593 35
  • 85.07 (n)
  • 88.81 (a)
chicken
(Gallus gallus)
Aves ZNF593 35
  • 67.45 (n)
  • 67.19 (a)
ZNF593 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF593 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf593 35
  • 55.11 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii znf593 35
  • 56.35 (n)
  • 53.17 (a)
znf593 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003698 35
  • 51.35 (n)
  • 46.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3224 35
  • 52.94 (n)
  • 47.06 (a)
CG3224 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.18 35
  • 51.18 (n)
  • 41.41 (a)
Y56A3A.18 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD20 36
  • 23 (a)
OneToOne
BUD20 38
Species with no ortholog for ZNF593:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF593 Gene

ENSEMBL:
Gene Tree for ZNF593 (if available)
TreeFam:
Gene Tree for ZNF593 (if available)

Paralogs for ZNF593 Gene

No data available for Paralogs for ZNF593 Gene

Variants for ZNF593 Gene

Sequence variations from dbSNP and Humsavar for ZNF593 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7087 -- 26,170,160(+) GGCGG(C/T)CTGCA synonymous-codon, reference
rs8768 -- 26,170,849(+) GCCCC(A/C)AATAA utr-variant-3-prime
rs945330 -- 26,169,184(-) TTCAC(A/G)GGAGC upstream-variant-2KB
rs1892494 -- 26,171,135(-) GGGGG(C/G)TGCAA downstream-variant-500B
rs2232645 -- 26,169,116(+) TGAAT(C/T)ATTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF593 Gene

Variant ID Type Subtype PubMed ID
nsv871237 CNV Loss 21882294

Relevant External Links for ZNF593 Gene

HapMap Linkage Disequilibrium report
ZNF593

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF593 Gene

Disorders for ZNF593 Gene

No disorders were found for ZNF593 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF593 Gene

Publications for ZNF593 Gene

  1. A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. (PMID: 9115366) Terunuma A. … Noda T. (Nucleic Acids Res. 1997) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. (PMID: 18287285) Hayes P.L. … Peterson F.C. (Protein Sci. 2008) 3 4
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ZNF593 Gene

Sources for ZNF593 Gene

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