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Aliases for SERPINA5 Gene

Aliases for SERPINA5 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 2 3
  • PCI 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 2 3
  • Acrosomal Serine Protease Inhibitor 3 4
  • Protein C Inhibitor 3 4
  • PLANH3 3 4
  • PAI-3 3 4
  • PROCI 3 4
  • PAI3 3 4
  • Plasminogen Activator Inhibitor III 3
  • Plasminogen Activator Inhibitor-3 3
  • Plasminogen Activator Inhibitor 3 4
  • Plasma Serine Protease Inhibitor 3
  • Serpin A5 4
  • SERPNA5 6
  • PCI-B 3

External Ids for SERPINA5 Gene

Previous HGNC Symbols for SERPINA5 Gene

  • PLANH3
  • PCI

Previous GeneCards Identifiers for SERPINA5 Gene

  • GC14P092555
  • GC14P088864
  • GC14P093018
  • GC14P093021
  • GC14P093037
  • GC14P094117
  • GC14P095047
  • GC14P075228

Summaries for SERPINA5 Gene

Entrez Gene Summary for SERPINA5 Gene

  • The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

GeneCards Summary for SERPINA5 Gene

SERPINA5 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5) is a Protein Coding gene. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. GO annotations related to this gene include heparin binding and protease binding. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA5 Gene

  • Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

Gene Wiki entry for SERPINA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA5 Gene

Genomics for SERPINA5 Gene

Regulatory Elements for SERPINA5 Gene

Genomic Location for SERPINA5 Gene

Start:
94,561,442 bp from pter
End:
94,593,120 bp from pter
Size:
31,679 bases
Orientation:
Plus strand

Genomic View for SERPINA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA5 Gene

Proteins for SERPINA5 Gene

  • Protein details for SERPINA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05154-IPSP_HUMAN
    Recommended name:
    Plasma serine protease inhibitor
    Protein Accession:
    P05154
    Secondary Accessions:
    • Q07616
    • Q9UG30

    Protein attributes for SERPINA5 Gene

    Size:
    406 amino acids
    Molecular mass:
    45675 Da
    Quaternary structure:
    • Forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen activator/PLAT and urinary plasminogen activator/PLAU. Forms membrane-anchored serine proteases inhibiting heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2.

    Three dimensional structures from OCA and Proteopedia for SERPINA5 Gene

neXtProt entry for SERPINA5 Gene

Proteomics data for SERPINA5 Gene at MOPED

Post-translational modifications for SERPINA5 Gene

  • N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.
  • Proteolytically cleaved. Inhibition of proteases is accompanied by formation of a stable enzyme-inhibitor complex and by degradation of the serpin to lower molecular weight derivatives. Proteolytically cleaved at the N-terminus; inhibits slightly the heparin- and thrombomodulin-enhanced rates of thrombin inhibition.
  • Glycosylation at Thr39, Asn249, Asn262, and Asn338
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SERPINA5 (Serpin A5/Protein C Inhibitor)

No data available for DME Specific Peptides for SERPINA5 Gene

Domains for SERPINA5 Gene

Gene Families for SERPINA5 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05154

UniProtKB/Swiss-Prot:

IPSP_HUMAN :
  • P05154
Domain:
  • The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA5: view

Function for SERPINA5 Gene

Molecular function for SERPINA5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Its inhibitory activity is greatly enhanced in the presence of glycosaminoglycans, heparin, thrombomodulin and phospholipids vesicles
UniProtKB/Swiss-Prot Function: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.

Gene Ontology (GO) - Molecular Function for SERPINA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 11722589
GO:0002020 protease binding IPI 10340997
GO:0004867 serine-type endopeptidase inhibitor activity IDA 10340997
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding TAS 8796266
genes like me logo Genes that share ontologies with SERPINA5: view

Phenotypes for SERPINA5 Gene

genes like me logo Genes that share phenotypes with SERPINA5: view

Animal Models for SERPINA5 Gene

MGI Knock Outs for SERPINA5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA5 Gene

Localization for SERPINA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA5 Gene

Secreted, extracellular space. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA5 Gene COMPARTMENTS Subcellular localization image for SERPINA5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SERPINA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IDA 7521127
GO:0005576 extracellular region TAS 11120760
GO:0005615 extracellular space IDA 10340997
GO:0009897 external side of plasma membrane IDA 9556620
GO:0016020 membrane IDA 7521127
genes like me logo Genes that share ontologies with SERPINA5: view

Pathways for SERPINA5 Gene

genes like me logo Genes that share pathways with SERPINA5: view

Pathways by source for SERPINA5 Gene

1 BioSystems pathway for SERPINA5 Gene
1 KEGG pathway for SERPINA5 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINA5 Gene
1 R&D Systems pathway for SERPINA5 Gene

Gene Ontology (GO) - Biological Process for SERPINA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0007283 spermatogenesis ISS --
GO:0007342 fusion of sperm to egg plasma membrane NAS 9510955
GO:0007596 blood coagulation TAS --
GO:0010951 negative regulation of endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SERPINA5: view

Compounds for SERPINA5 Gene

(2) Drugbank Compounds for SERPINA5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Drotrecogin alfa
  • Anticoagulant protein C
60202-16-6 target
Urokinase
  • U-plasminogen activator
9039-53-6 target

(4) Novoseek inferred chemical compound relationships for SERPINA5 Gene

Compound -log(P) Hits PubMed IDs
serine 50.9 8
heparin 48.6 2
fibrinogen 36.3 2
warfarin 28.5 1
genes like me logo Genes that share compounds with SERPINA5: view

Transcripts for SERPINA5 Gene

Unigene Clusters for SERPINA5 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4:
SP5: - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:

ExUns: 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SERPINA5 Gene

GeneLoc Exon Structure for
SERPINA5
ECgene alternative splicing isoforms for
SERPINA5

Expression for SERPINA5 Gene

mRNA expression in normal human tissues for SERPINA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA5 Gene

This gene is overexpressed in Adrenal Gland (19.6), Testis (9.5), and Liver (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINA5 Gene

SOURCE GeneReport for Unigene cluster for SERPINA5 Gene Hs.159628

mRNA Expression by UniProt/SwissProt for SERPINA5 Gene

P05154-IPSP_HUMAN
Tissue specificity: Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
genes like me logo Genes that share expressions with SERPINA5: view

In Situ Assay Products

Orthologs for SERPINA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SERPINA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINA5 35
  • 97.07 (n)
  • 96.61 (a)
SERPINA5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINA5 35
  • 79.95 (n)
  • 71.98 (a)
SERPINA5 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINA5 35
  • 81.07 (n)
  • 72.84 (a)
SERPINA5 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina5 35
  • 73.94 (n)
  • 64.68 (a)
Serpina5 16
Serpina5 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINA5 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpina5 35
  • 73.88 (n)
  • 64.18 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-1 37
  • 29 (a)
Species with no ortholog for SERPINA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINA5 Gene

ENSEMBL:
Gene Tree for SERPINA5 (if available)
TreeFam:
Gene Tree for SERPINA5 (if available)

Paralogs for SERPINA5 Gene

genes like me logo Genes that share paralogs with SERPINA5: view

Variants for SERPINA5 Gene

Sequence variations from dbSNP and Humsavar for SERPINA5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs938 -- 94,592,476(+) GATTA(A/G)CACTG utr-variant-3-prime
rs6107 -- 94,590,933(+) CCAAG(A/G)TCTAT intron-variant
rs6108 -- 94,592,294(+) GGCTA(A/T)GCTAT utr-variant-3-prime
rs6109 -- 94,592,023(+) CCCCT(A/G)GTGGC intron-variant
rs6110 -- 94,592,356(+) TGAGG(C/T)ATTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINA5 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832865 CNV Gain 17160897

Relevant External Links for SERPINA5 Gene

HapMap Linkage Disequilibrium report
SERPINA5
Human Gene Mutation Database (HGMD)
SERPINA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA5 Gene

Disorders for SERPINA5 Gene

(2) Novoseek inferred disease relationships for SERPINA5 Gene

Disease -log(P) Hits PubMed IDs
venous thrombosis 21.7 2
tumors 0 3

Relevant External Links for SERPINA5

Genetic Association Database (GAD)
SERPINA5
Human Genome Epidemiology (HuGE) Navigator
SERPINA5
genes like me logo Genes that share disorders with SERPINA5: view

No data available for UniProtKB/Swiss-Prot for SERPINA5 Gene

Publications for SERPINA5 Gene

  1. Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14. (PMID: 1714450) Meijers J.C.M. … Chung D.W. (J. Biol. Chem. 1991) 2 3 4 23
  2. Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. (PMID: 1725227) Espana F. … Cabo A. (Thromb. Res. 1991) 3 4 23
  3. Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft. (PMID: 15878512) Glasscock L.N. … Church F.C. (Exp. Mol. Pathol. 2005) 3 23
  4. Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system. (PMID: 1372913) Laurell M. … Lilja H. (J. Clin. Invest. 1992) 3 4
  5. Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. (PMID: 2172989) Kuhn L.A. … Tainer J.A. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4

Products for SERPINA5 Gene

Sources for SERPINA5 Gene

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