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Aliases for VPS36 Gene

Aliases for VPS36 Gene

  • Vacuolar Protein Sorting 36 Homolog 2 3
  • Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae) 2 5
  • ELL-Associated Protein Of 45 KDa 3 4
  • ESCRT-II Complex Subunit VPS36 3 4
  • C13orf9 3 4
  • EAP45 3 4
  • Vacuolar Protein Sorting 36 Homolog (Yeast) 2
  • Chromosome 13 Open Reading Frame 9 2
  • CGI-145 3

External Ids for VPS36 Gene

Previous HGNC Symbols for VPS36 Gene

  • C13orf9

Previous GeneCards Identifiers for VPS36 Gene

  • GC13M051885
  • GC13M052986
  • GC13M033725

Summaries for VPS36 Gene

Entrez Gene Summary for VPS36 Gene

  • This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

GeneCards Summary for VPS36 Gene

VPS36 (Vacuolar Protein Sorting 36 Homolog) is a Protein Coding gene. Among its related pathways are Endocytosis and Vesicle-mediated transport. GO annotations related to this gene include protein C-terminus binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for VPS36 Gene

  • Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Gene Wiki entry for VPS36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS36 Gene

Genomics for VPS36 Gene

Regulatory Elements for VPS36 Gene

Promoters for VPS36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VPS36 on UCSC Golden Path with GeneCards custom track

Genomic Location for VPS36 Gene

Chromosome:
13
Start:
52,412,602 bp from pter
End:
52,450,678 bp from pter
Size:
38,077 bases
Orientation:
Minus strand

Genomic View for VPS36 Gene

Genes around VPS36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS36 Gene

Proteins for VPS36 Gene

  • Protein details for VPS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VN1-VPS36_HUMAN
    Recommended name:
    Vacuolar protein-sorting-associated protein 36
    Protein Accession:
    Q86VN1
    Secondary Accessions:
    • A8K125
    • Q3ZCV7
    • Q5H9S1
    • Q5VXB6
    • Q9H8Z5
    • Q9Y3E3

    Protein attributes for VPS36 Gene

    Size:
    386 amino acids
    Molecular mass:
    43817 Da
    Quaternary structure:
    • Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25 (PubMed:14519844). Interacts with VPS25, SNF8, TSG101 and CHMP6 (PubMed:14505570, PubMed:14519844, PubMed:16973552, PubMed:18539118). Interacts (via GLUE domain) with ubiquitin (PubMed:17057716). Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes (PubMed:17010938). Interacts with ECM29 (PubMed:20682791).
    SequenceCaution:
    • Sequence=BAB14451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VPS36 Gene

    Alternative splice isoforms for VPS36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS36 Gene

Proteomics data for VPS36 Gene at MOPED

Post-translational modifications for VPS36 Gene

  • Ubiquitination at Lys 102, Lys 107, Lys 218, and Lys 298
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS36 Gene

Antibody Products

No data available for DME Specific Peptides for VPS36 Gene

Domains & Families for VPS36 Gene

Gene Families for VPS36 Gene

Protein Domains for VPS36 Gene

Suggested Antigen Peptide Sequences for VPS36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VN1

UniProtKB/Swiss-Prot:

VPS36_HUMAN :
  • The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • Belongs to the VPS36 family.
Domain:
  • The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • Contains 1 GLUE C-terminal domain.
  • Contains 1 GLUE N-terminal domain.
Family:
  • Belongs to the VPS36 family.
genes like me logo Genes that share domains with VPS36: view

Function for VPS36 Gene

Molecular function for VPS36 Gene

UniProtKB/Swiss-Prot Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Gene Ontology (GO) - Molecular Function for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
genes like me logo Genes that share ontologies with VPS36: view
genes like me logo Genes that share phenotypes with VPS36: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS36 Gene

Localization for VPS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS36 Gene

Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250 UniProtKB:Q91XD6}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS36 Gene COMPARTMENTS Subcellular localization image for VPS36 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
nucleus 4
lysosome 3
vacuole 3

Gene Ontology (GO) - Cellular Components for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005768 endosome IDA 20682791
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VPS36: view

Pathways & Interactions for VPS36 Gene

genes like me logo Genes that share pathways with VPS36: view

Pathways by source for VPS36 Gene

Gene Ontology (GO) - Biological Process for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016197 endosomal transport TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with VPS36: view

No data available for SIGNOR curated interactions for VPS36 Gene

Drugs & Compounds for VPS36 Gene

No Compound Related Data Available

Transcripts for VPS36 Gene

Unigene Clusters for VPS36 Gene

Vacuolar protein sorting 36 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - - - -

Relevant External Links for VPS36 Gene

GeneLoc Exon Structure for
VPS36
ECgene alternative splicing isoforms for
VPS36

Expression for VPS36 Gene

mRNA expression in normal human tissues for VPS36 Gene

Protein differential expression in normal tissues from HIPED for VPS36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.2), Skin (7.6), and Salivary gland (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS36 Gene



SOURCE GeneReport for Unigene cluster for VPS36 Gene Hs.109520

genes like me logo Genes that share expression patterns with VPS36: view

Protein tissue co-expression partners for VPS36 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS36 Gene

Orthologs for VPS36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VPS36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS36 36
  • 100 (a)
OneToOne
VPS36 35
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia VPS36 36
  • 98 (a)
OneToOne
VPS36 35
  • 92.4 (n)
  • 97.93 (a)
dog
(Canis familiaris)
Mammalia VPS36 35
  • 93.87 (n)
  • 98.96 (a)
VPS36 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps36 16
Vps36 36
  • 96 (a)
OneToOne
Vps36 35
  • 90.33 (n)
  • 95.85 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS36 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vps36 35
  • 90.24 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves VPS36 36
  • 90 (a)
OneToOne
VPS36 35
  • 80.57 (n)
  • 89.64 (a)
lizard
(Anolis carolinensis)
Reptilia VPS36 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13768 35
vps36 35
  • 76.68 (n)
  • 85.49 (a)
zebrafish
(Danio rerio)
Actinopterygii vps36 35
  • 73.91 (n)
  • 85.08 (a)
wufj33d07 35
vps36 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004755 35
  • 51.68 (n)
  • 45.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps36 36
  • 45 (a)
OneToOne
Vps36 35
  • 54.3 (n)
  • 47.37 (a)
worm
(Caenorhabditis elegans)
Secernentea vps-36 36
  • 42 (a)
OneToOne
vps-36 35
  • 51.32 (n)
  • 43.12 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER092W 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS36 35
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02541g 35
  • 40.73 (n)
  • 28.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06595 35
  • 46.41 (n)
  • 36.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vps36 35
  • 40.43 (n)
  • 24.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4113 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for VPS36:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS36 Gene

ENSEMBL:
Gene Tree for VPS36 (if available)
TreeFam:
Gene Tree for VPS36 (if available)

Paralogs for VPS36 Gene

No data available for Paralogs for VPS36 Gene

Variants for VPS36 Gene

Sequence variations from dbSNP and Humsavar for VPS36 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3196949 -- 52,415,554(-) AACTT(C/G)ATCCT utr-variant-3-prime
rs4536354 -- 52,430,974(+) GAAAA(C/G/T)TGACC intron-variant
rs4886018 -- 52,416,582(+) CAGTA(C/T)TATTT intron-variant
rs4886098 -- 52,427,998(+) TAAAC(A/G)GGTAT intron-variant
rs4884354 -- 52,443,339(+) CTCAA(C/T)GCGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS36 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
dgv1588n71 CNV Loss 21882294

Variation tolerance for VPS36 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS36 Gene

HapMap Linkage Disequilibrium report
VPS36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS36 Gene

Disorders for VPS36 Gene

Relevant External Links for VPS36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS36

No disorders were found for VPS36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS36 Gene

Publications for VPS36 Gene

  1. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 3 4 67
  2. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide- interacting GLUE domain. (PMID: 15755741) Slagsvold T. … Stenmark H. (J. Biol. Chem. 2005) 2 3
  3. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. (PMID: 11278625) Kamura T. … Shilatifard A. (J. Biol. Chem. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for VPS36 Gene

Sources for VPS36 Gene

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