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Aliases for SLC35C2 Gene

Aliases for SLC35C2 Gene

  • Solute Carrier Family 35 (GDP-Fucose Transporter), Member C2 2 3
  • Ovarian Cancer-Overexpressed Gene 1 Protein 3 4
  • C20orf5 3 4
  • OVCOV1 3 4
  • Solute Carrier Family 35, Member C2 2
  • Solute Carrier Family 35 Member C2 3
  • Ovarian Cancer Overexpressed 1 2
  • BA394O2.1 3
  • CGI-15 3

External Ids for SLC35C2 Gene

Previous HGNC Symbols for SLC35C2 Gene

  • C20orf5
  • OVCOV1

Previous GeneCards Identifiers for SLC35C2 Gene

  • GC20M045616
  • GC20M045663
  • GC20M044411
  • GC20M044978
  • GC20M041719

Summaries for SLC35C2 Gene

Entrez Gene Summary for SLC35C2 Gene

  • This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35C2 Gene

SLC35C2 (Solute Carrier Family 35 (GDP-Fucose Transporter), Member C2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35C2 Gene

  • May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.

Gene Wiki entry for SLC35C2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35C2 Gene

Genomics for SLC35C2 Gene

Regulatory Elements for SLC35C2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC35C2 Gene

Start:
46,345,980 bp from pter
End:
46,364,458 bp from pter
Size:
18,479 bases
Orientation:
Minus strand

Genomic View for SLC35C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35C2 Gene

Proteins for SLC35C2 Gene

  • Protein details for SLC35C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQQ7-S35C2_HUMAN
    Recommended name:
    Solute carrier family 35 member C2
    Protein Accession:
    Q9NQQ7
    Secondary Accessions:
    • B7Z6V6
    • E1P5T0
    • Q53GK3
    • Q5JW05
    • Q96CJ8
    • Q9Y304

    Protein attributes for SLC35C2 Gene

    Size:
    365 amino acids
    Molecular mass:
    40432 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27724.1; Type=Frameshift; Positions=168, 211, 305; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35C2 Gene

Proteomics data for SLC35C2 Gene at MOPED

Post-translational modifications for SLC35C2 Gene

Antibody Products

No data available for DME Specific Peptides for SLC35C2 Gene

Domains for SLC35C2 Gene

Gene Families for SLC35C2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC35C2 Gene

Suggested Antigen Peptide Sequences for SLC35C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQQ7

UniProtKB/Swiss-Prot:

S35C2_HUMAN :
  • Q9NQQ7
Family:
  • Belongs to the TPT transporter family. SLC35C subfamily.
genes like me logo Genes that share domains with SLC35C2: view

Function for SLC35C2 Gene

Molecular function for SLC35C2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
UniProtKB/Swiss-Prot Induction:
In hypoxic trophoblast cells

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC35C2 Gene

Localization for SLC35C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35C2 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35C2 Gene COMPARTMENTS Subcellular localization image for SLC35C2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 20837470
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IDA 20837470
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

Pathways for SLC35C2 Gene

SuperPathways for SLC35C2 Gene

No Data Available

Interacting Proteins for SLC35C2 Gene

Gene Ontology (GO) - Biological Process for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0036065 fucosylation --
GO:0036066 protein O-linked fucosylation IEA --
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

No data available for Pathways by source for SLC35C2 Gene

Transcripts for SLC35C2 Gene

Unigene Clusters for SLC35C2 Gene

Solute carrier family 35, member C2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35C2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35C2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - - - - - - - -
SP15: - - - - - -
SP16: - - -
SP17: - -
SP18: - -
SP19: - - - - - -
SP20: - - - - - -
SP21: - - - -
SP22: - - - - - -
SP23: - - -
SP24: -
SP25: - - -
SP26: -
SP27:
SP28: - - - -
SP29: - -

ExUns: 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15a · 15b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17: -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for SLC35C2 Gene

GeneLoc Exon Structure for
SLC35C2
ECgene alternative splicing isoforms for
SLC35C2

Expression for SLC35C2 Gene

mRNA expression in normal human tissues for SLC35C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLC35C2 Gene

This gene is overexpressed in Cervix (32.6) and Spleen (31.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC35C2 Gene

SOURCE GeneReport for Unigene cluster for SLC35C2 Gene Hs.593344

mRNA Expression by UniProt/SwissProt for SLC35C2 Gene

Q9NQQ7-S35C2_HUMAN
Tissue specificity: Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer
genes like me logo Genes that share expressions with SLC35C2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SLC35C2 Gene

Orthologs for SLC35C2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35C2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35C2 35
  • 92.28 (n)
  • 95.25 (a)
SLC35C2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35C2 35
  • 91.6 (n)
  • 95.89 (a)
SLC35C2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35c2 35
  • 88.37 (n)
  • 94.78 (a)
Slc35c2 16
Slc35c2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35C2 35
  • 99.63 (n)
  • 100 (a)
SLC35C2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35c2 35
  • 88.92 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35C2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35C2 35
  • 72.35 (n)
  • 72.65 (a)
SLC35C2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35C2 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6085 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7973 35
slc35c2 35
  • 66.28 (n)
  • 67.93 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005537 35
  • 54.88 (n)
  • 42.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14971 35
  • 55.48 (n)
  • 47.95 (a)
CG14971 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y47G6A.7 35
  • 47.67 (n)
  • 42.67 (a)
Y47G6A.7 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR462C 35
  • 46.25 (n)
  • 30.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10131g 35
  • 43.69 (n)
  • 34.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMD8 35
  • 44.41 (n)
  • 35.29 (a)
YMD8 36
  • 25 (a)
OneToOne
YMD8 38
YMD8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06470 35
  • 45.86 (n)
  • 36.9 (a)
rice
(Oryza sativa)
Liliopsida Os01g0749900 35
  • 46.78 (n)
  • 36.61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8485 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC22E12.01 35
  • 42.32 (n)
  • 34.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4074 36
  • 55 (a)
OneToOne
Species with no ortholog for SLC35C2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35C2 Gene

ENSEMBL:
Gene Tree for SLC35C2 (if available)
TreeFam:
Gene Tree for SLC35C2 (if available)

Paralogs for SLC35C2 Gene

Pseudogenes.org Pseudogenes for SLC35C2 Gene

genes like me logo Genes that share paralogs with SLC35C2: view

No data available for Paralogs for SLC35C2 Gene

Variants for SLC35C2 Gene

Sequence variations from dbSNP and Humsavar for SLC35C2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs911435 -- 46,356,668(+) ACAGC(G/T)TGGGA intron-variant
rs911436 -- 46,357,079(+) AAACA(C/T)TTTGA intron-variant
rs1044369 -- 46,358,679(-) ACTCT(C/G)CCTGG utr-variant-5-prime, intron-variant
rs1475047 -- 46,355,585(+) CATCC(C/T)GCAGT intron-variant
rs2258427 -- 46,364,080(+) CAGCC(C/T)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35C2 Gene

Variant ID Type Subtype PubMed ID
nsv912899 CNV Loss 21882294
esv2722457 CNV Deletion 23290073

Relevant External Links for SLC35C2 Gene

HapMap Linkage Disequilibrium report
SLC35C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35C2 Gene

Disorders for SLC35C2 Gene

Relevant External Links for SLC35C2

Genetic Association Database (GAD)
SLC35C2

No disorders were found for SLC35C2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC35C2 Gene

Publications for SLC35C2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PMID: 11549316) Fossey S.C. … Bowden D.W. (Genomics 2001) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization. (PMID: 11856893) Leach R.E. … Krawetz S.A. (Cytogenet. Cell Genet. 2001) 3 4
  5. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. (PMID: 20837470) Lu L. … Stanley P. (J. Biol. Chem. 2010) 3 4

Products for SLC35C2 Gene

Sources for SLC35C2 Gene

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