Aliases for TBX22 Gene
External Ids for TBX22 Gene
Previous HGNC Symbols for TBX22 Gene
Previous GeneCards Identifiers for TBX22 Gene
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBX22 Gene
TBX22 (T-Box 22) is a Protein Coding gene. Diseases associated with TBX22 include Abruzzo-Erickson Syndrome and Cleft Palate With Ankyloglossia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TBX20.
UniProtKB/Swiss-Prot for TBX22 Gene
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.