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Aliases for PDE11A Gene

Aliases for PDE11A Gene

  • Phosphodiesterase 11A 2 3
  • EC 3.1.4.35 4 63
  • PPNAD2 3 6
  • CAMP And CGMP Cyclic Nucleotide Phosphodiesterase 11A 3
  • Dual 3,5-Cyclic-AMP And -GMP Phosphodiesterase 11A 3
  • CAMP And CGMP Phosphodiesterase 11A 4
  • EC 3.1.4.17 4
  • EC 3.1.4 63
  • PDE11A1 6
  • PDE11A2 6
  • PDE11A3 6

External Ids for PDE11A Gene

Previous GeneCards Identifiers for PDE11A Gene

  • GC02M176555
  • GC02M177163
  • GC02M178455
  • GC02M178695
  • GC02M178318
  • GC02M178201
  • GC02M178487
  • GC02M170359

Summaries for PDE11A Gene

Entrez Gene Summary for PDE11A Gene

  • The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDE11A Gene

PDE11A (Phosphodiesterase 11A) is a Protein Coding gene. Diseases associated with PDE11A include pigmented nodular adrenocortical disease, primary, 2 and primary pigmented nodular adrenocortical disease. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cAMP binding and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE11A Gene

  • Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively.

Tocris Summary for PDE11A Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE11A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE11A Gene

Genomics for PDE11A Gene

Regulatory Elements for PDE11A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE11A Gene

Start:
177,623,249 bp from pter
End:
178,108,339 bp from pter
Size:
485,091 bases
Orientation:
Minus strand

Genomic View for PDE11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE11A Gene

Proteins for PDE11A Gene

  • Protein details for PDE11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCR9-PDE11_HUMAN
    Recommended name:
    Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A
    Protein Accession:
    Q9HCR9
    Secondary Accessions:
    • Q14CD1
    • Q53T16
    • Q96S76
    • Q9GZY7
    • Q9HB46
    • Q9NY45

    Protein attributes for PDE11A Gene

    Size:
    933 amino acids
    Molecular mass:
    104752 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PDE11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE11A Gene

Proteomics data for PDE11A Gene at MOPED

Selected DME Specific Peptides for PDE11A Gene

Post-translational modifications for PDE11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE11A Gene

Domains for PDE11A Gene

Gene Families for PDE11A Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE11A Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCR9

UniProtKB/Swiss-Prot:

PDE11_HUMAN :
  • Q9HCR9
Domain:
  • The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity.
  • Contains 2 GAF domains.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family.
genes like me logo Genes that share domains with PDE11A: view

Function for PDE11A Gene

Molecular function for PDE11A Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.0 uM for cAMP (isoform 1) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=1.4 uM for cGMP (isoform 1) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=3.0 uM for cAMP (isoform 2) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=1.5 uM for cGMP (isoform 2) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=3.3 uM for cAMP (isoform 3) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=3.7 uM for cGMP (isoform 3) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=1.04 uM for cAMP (isoform 4) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; KM=0.52 uM for cGMP (isoform 4) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; Vmax=3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; Vmax=3.9 pmol/min/ug enzyme with cGMP as substrate (isoform 4) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; Vmax=270 pmol/min/ug enzyme with cAMP as substrate (isoform 1) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148}; Vmax=120 pmol/min/ug enzyme with cGMP as substrate (isoform 1) {ECO:0000269 PubMed:10725373, ECO:0000269 PubMed:10906126, ECO:0000269 PubMed:11050148};
UniProtKB/Swiss-Prot CatalyticActivity: Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate
UniProtKB/Swiss-Prot CatalyticActivity: Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator. Weakly inhibited by Sildenafil (Viagra) and Tadalafil (Cialis); however, the fact that the protein is probably absent from testis, suggests that it is not biologically relevant and is not related with erectile dysfunction.
UniProtKB/Swiss-Prot Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively.

Enzyme Numbers (IUBMB) for PDE11A Gene

Gene Ontology (GO) - Molecular Function for PDE11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004112 cyclic-nucleotide phosphodiesterase activity NAS 10906126
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity TAS 10725373
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA 19689430
GO:0005515 protein binding --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with PDE11A: view

Phenotypes for PDE11A Gene

genes like me logo Genes that share phenotypes with PDE11A: view

Animal Model Products

CRISPR Products

miRNA for PDE11A Gene

miRTarBase miRNAs that target PDE11A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE11A Gene

Localization for PDE11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE11A Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE11A Gene COMPARTMENTS Subcellular localization image for PDE11A gene
Compartment Confidence
cytosol 5
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PDE11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with PDE11A: view

Pathways for PDE11A Gene

genes like me logo Genes that share pathways with PDE11A: view

Pathways by source for PDE11A Gene

Interacting Proteins for PDE11A Gene

Gene Ontology (GO) - Biological Process for PDE11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0046069 cGMP catabolic process IEA --
genes like me logo Genes that share ontologies with PDE11A: view

Compounds for PDE11A Gene

(5) Tocris Compounds for PDE11A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(6) HMDB Compounds for PDE11A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Sildenafil
  • Caverta
139755-83-2

(1) Drugbank Compounds for PDE11A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tadalafil
  • ICOS 351
171596-29-5 target inhibitor

(3) Novoseek inferred chemical compound relationships for PDE11A Gene

Compound -log(P) Hits PubMed IDs
cgmp 68 8
zaprinast 67.1 1
dipyridamole 45.1 1
genes like me logo Genes that share compounds with PDE11A: view

Transcripts for PDE11A Gene

mRNA/cDNA for PDE11A Gene

Unigene Clusters for PDE11A Gene

Phosphodiesterase 11A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE11A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PDE11A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE11A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b
SP1: - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for PDE11A Gene

GeneLoc Exon Structure for
PDE11A
ECgene alternative splicing isoforms for
PDE11A

Expression for PDE11A Gene

mRNA expression in normal human tissues for PDE11A Gene

mRNA differential expression in normal tissues according to GTEx for PDE11A Gene

This gene is overexpressed in Prostate (9.1), Muscle - Skeletal (8.8), Liver (4.6), and Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDE11A Gene

SOURCE GeneReport for Unigene cluster for PDE11A Gene Hs.570273

mRNA Expression by UniProt/SwissProt for PDE11A Gene

Q9HCR9-PDE11_HUMAN
Tissue specificity: Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
genes like me logo Genes that share expressions with PDE11A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PDE11A Gene

Orthologs for PDE11A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE11A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE11A 35
  • 91.06 (n)
  • 94.81 (a)
PDE11A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE11A 35
  • 93.13 (n)
  • 96.13 (a)
PDE11A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde11a 35
  • 88.63 (n)
  • 94.64 (a)
Pde11a 16
Pde11a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE11A 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE11A 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde11a 35
  • 88.97 (n)
  • 95.4 (a)
chicken
(Gallus gallus)
Aves PDE11A 35
  • 82.56 (n)
  • 91.37 (a)
PDE11A 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE11A 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde11a 35
  • 78.16 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii pde11a 35
  • 74.02 (n)
  • 85.71 (a)
pde11a 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004119 35
  • 54.32 (n)
  • 48.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pde11 36
  • 27 (a)
OneToMany
Pde6 35
  • 52.21 (n)
  • 45.97 (a)
CG8279 37
  • 43 (a)
CG10231 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea C32E12.2 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for PDE11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE11A Gene

ENSEMBL:
Gene Tree for PDE11A (if available)
TreeFam:
Gene Tree for PDE11A (if available)

Paralogs for PDE11A Gene

Paralogs for PDE11A Gene

genes like me logo Genes that share paralogs with PDE11A: view

Variants for PDE11A Gene

Sequence variations from dbSNP and Humsavar for PDE11A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs714528 -- 177,730,645(-) CCAGA(C/T)GACAA intron-variant
rs714529 -- 177,730,846(-) ctact(C/G)tactg intron-variant
rs726985 -- 177,968,644(-) TTTAA(A/T)AATGG intron-variant
rs732363 -- 177,826,479(-) GAACA(A/T)TGGCT intron-variant
rs736842 -- 178,086,749(-) TTTAA(C/T)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE11A Gene

Variant ID Type Subtype PubMed ID
nsv819130 CNV Gain 19587683
nsv525762 CNV Loss 19592680
esv2721182 CNV Deletion 23290073
esv2721183 CNV Deletion 23290073
esv2721185 CNV Deletion 23290073
nsv213289 CNV Loss 16902084
esv275124 CNV Loss 21479260
esv2465411 CNV Insertion 19546169
esv274637 CNV Insertion 20981092
esv268122 CNV Insertion 20981092
esv2721186 CNV Deletion 23290073
esv1970130 CNV Deletion 18987734
esv2721187 CNV Deletion 23290073
nsv528219 CNV Gain 19592680
esv7012 CNV Gain 19470904
nsv3052 CNV Insertion 18451855
esv2606430 CNV Insertion 19546169
esv269406 CNV Insertion 20981092
esv273152 CNV Insertion 20981092
esv274308 CNV Insertion 20981092
esv269818 CNV Insertion 20981092
esv22087 CNV Loss 19812545
nsv3053 CNV Loss 18451855
esv2721188 CNV Deletion 23290073
esv21845 CNV Loss 19812545
esv2661066 CNV Deletion 23128226
nsv875451 CNV Loss 21882294
nsv3055 CNV Loss 18451855
esv1296090 CNV Deletion 17803354
esv1224166 CNV Deletion 17803354
nsv215311 CNV Loss 16902084
esv24708 CNV Loss 19812545
nsv511190 CNV Loss 21212237
dgv94e180 CNV Loss 20482838
nsv521228 CNV Loss 19592680
esv2721189 CNV Deletion 23290073
esv2678243 CNV Deletion 23128226
dgv678n67 CNV Loss 20364138
esv27415 CNV Loss 19812545
esv2667251 CNV Deletion 23128226
nsv213683 CNV Insertion 16902084
esv1338881 CNV Insertion 17803354
esv268702 CNV Insertion 20981092
nsv518790 CNV Gain 19592680
nsv875452 CNV Gain 21882294

Relevant External Links for PDE11A Gene

HapMap Linkage Disequilibrium report
PDE11A
Human Gene Mutation Database (HGMD)
PDE11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE11A Gene

Disorders for PDE11A Gene

(1) OMIM Diseases for PDE11A Gene (604961)

UniProtKB/Swiss-Prot

PDE11_HUMAN
  • Primary pigmented nodular adrenocortical disease 2 (PPNAD2) [MIM:610475]: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269 PubMed:16767104}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for PDE11A Gene

(4) Novoseek inferred disease relationships for PDE11A Gene

Disease -log(P) Hits PubMed IDs
cushing syndrome 81.4 3
hyperplasia 63.4 5
tumors 20.9 12
carcinoma 0 1

Relevant External Links for PDE11A

Genetic Association Database (GAD)
PDE11A
Human Genome Epidemiology (HuGE) Navigator
PDE11A
genes like me logo Genes that share disorders with PDE11A: view

Publications for PDE11A Gene

  1. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. (PMID: 10725373) Fawcett L. … Phillips S.C. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. (PMID: 10906126) Yuasa K. … Omori K. (J. Biol. Chem. 2000) 3 4 23
  3. Cloning and characterisation of two splice variants of human phosphodiesterase 11A. (PMID: 11050148) Hetman J.M. … Beavo J.A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  4. 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues. (PMID: 15800651) Loughney K. … Florio V.A. (Int. J. Impot. Res. 2005) 3 4 23
  5. Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population. (PMID: 17178847) Horvath A. … Stratakis C.A. (Cancer Res. 2006) 3 23 48

Products for PDE11A Gene

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  • antibodies-online kits for PDE11A

Sources for PDE11A Gene

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