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Aliases for CDON Gene

Aliases for CDON Gene

  • Cell Adhesion Associated, Oncogene Regulated 2 3 5
  • CDO 3 4
  • Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes 2
  • Surface Glycoprotein, Ig Superfamily Member 3
  • Cdon Homolog (Mouse) 2
  • Cdon Homolog 3
  • CDON1 3
  • HPE11 3
  • ORCAM 3

External Ids for CDON Gene

Previous GeneCards Identifiers for CDON Gene

  • GC11M127831
  • GC11M127343
  • GC11M125866
  • GC11M125368
  • GC11M125335
  • GC11M121768

Summaries for CDON Gene

Entrez Gene Summary for CDON Gene

  • This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

GeneCards Summary for CDON Gene

CDON (Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Diseases associated with CDON include Holoprosencephaly 11 and Microform Holoprosencephaly. Among its related pathways are Developmental Biology and Signaling by Hedgehog. An important paralog of this gene is IGDCC3.

UniProtKB/Swiss-Prot for CDON Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Gene Wiki entry for CDON Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDON Gene

Genomics for CDON Gene

Regulatory Elements for CDON Gene

Enhancers for CDON Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDON on UCSC Golden Path with GeneCards custom track

Promoters for CDON Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDON on UCSC Golden Path with GeneCards custom track

Genomic Location for CDON Gene

Chromosome:
11
Start:
125,955,796 bp from pter
End:
126,063,335 bp from pter
Size:
107,540 bases
Orientation:
Minus strand

Genomic View for CDON Gene

Genes around CDON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDON Gene

Proteins for CDON Gene

  • Protein details for CDON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMG0-CDON_HUMAN
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Protein Accession:
    Q4KMG0
    Secondary Accessions:
    • O14631

    Protein attributes for CDON Gene

    Size:
    1287 amino acids
    Molecular mass:
    139147 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.

    Three dimensional structures from OCA and Proteopedia for CDON Gene

    Alternative splice isoforms for CDON Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDON Gene

Proteomics data for CDON Gene at MOPED

Post-translational modifications for CDON Gene

  • N-glycosylated.
  • Glycosylation at Asn 88, Asn 100, Asn 180, Asn 287, Asn 294, Asn 342, Asn 427, Asn 570, Asn 873, and Ser 932
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDON Gene

Domains & Families for CDON Gene

Protein Domains for CDON Gene

Suggested Antigen Peptide Sequences for CDON Gene

Graphical View of Domain Structure for InterPro Entry

Q4KMG0

UniProtKB/Swiss-Prot:

CDON_HUMAN :
  • Contains 3 fibronectin type-III domains.
Domain:
  • Contains 3 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CDON: view

Function for CDON Gene

Molecular function for CDON Gene

UniProtKB/Swiss-Prot Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
genes like me logo Genes that share phenotypes with CDON: view

Human Phenotype Ontology for CDON Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDON Gene

MGI Knock Outs for CDON:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDON

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CDON Gene

Localization for CDON Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDON Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDON Gene COMPARTMENTS Subcellular localization image for CDON gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CDON: view

Pathways & Interactions for CDON Gene

genes like me logo Genes that share pathways with CDON: view

Pathways by source for CDON Gene

SIGNOR curated interactions for CDON Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007155 cell adhesion TAS 9214393
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with CDON: view

Drugs & Compounds for CDON Gene

No Compound Related Data Available

Transcripts for CDON Gene

Unigene Clusters for CDON Gene

Cell adhesion associated, oncogene regulated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDON Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for CDON Gene

GeneLoc Exon Structure for
CDON
ECgene alternative splicing isoforms for
CDON

Expression for CDON Gene

mRNA expression in normal human tissues for CDON Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDON Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDON Gene

This gene is overexpressed in Testis (33.0), Plasma (21.7), and Vitreous humor (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDON Gene



SOURCE GeneReport for Unigene cluster for CDON Gene Hs.38034

genes like me logo Genes that share expression patterns with CDON: view

Protein tissue co-expression partners for CDON Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDON Gene

Orthologs for CDON Gene

This gene was present in the common ancestor of animals.

Orthologs for CDON Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDON 35
  • 84.84 (n)
  • 83.56 (a)
CDON 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDON 35
  • 86.95 (n)
  • 84.93 (a)
CDON 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdon 35
  • 82.43 (n)
  • 82.48 (a)
Cdon 16
Cdon 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDON 35
  • 98.81 (n)
  • 98.18 (a)
CDON 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdon 35
  • 81.49 (n)
  • 81.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CDON 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDON 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDON 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDON 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdon 35
  • 62.76 (n)
  • 57.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia cdon-A 35
zebrafish
(Danio rerio)
Actinopterygii wufa10c02 35
cdon 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta boi 36
  • 20 (a)
ManyToMany
CG6490 36
  • 14 (a)
ManyToMany
ihog 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for CDON:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDON Gene

ENSEMBL:
Gene Tree for CDON (if available)
TreeFam:
Gene Tree for CDON (if available)

Paralogs for CDON Gene

Paralogs for CDON Gene

(7) SIMAP similar genes for CDON Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CDON: view

Variants for CDON Gene

Sequence variations from dbSNP and Humsavar for CDON Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7122277 - 126,021,400(+) ATGTT(C/T)TTCCG reference, missense
rs3740909 - 126,019,631(+) ATGTT(C/T)CAGCC reference, missense
rs35665264 - 126,015,388(+) AATAG(C/G)CTGTG reference, missense
rs12274923 - 126,001,820(+) AGGAT(A/G)CCTGG reference, missense
rs145983470 Holoprosencephaly 11 (HPE11) 126,001,826(+) CCTGG(C/G)TGTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDON Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407
nsv535 CNV Loss 18451855
nsv819513 CNV Loss 19587683

Variation tolerance for CDON Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDON Gene

Human Gene Mutation Database (HGMD)
CDON

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDON Gene

Disorders for CDON Gene

MalaCards: The human disease database

(12) MalaCards diseases for CDON Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly 11
  • holoprosencephaly-11
microform holoprosencephaly
  • microform hpe
pituitary stalk interruption syndrome
  • ectopic neurohypophysis
semilobar holoprosencephaly
lobar holoprosencephaly
- elite association - COSMIC cancer census association via MalaCards
Search CDON in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDON_HUMAN
  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269 PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDON

Genetic Association Database (GAD)
CDON
Human Genome Epidemiology (HuGE) Navigator
CDON
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDON
genes like me logo Genes that share disorders with CDON: view

No data available for Genatlas for CDON Gene

Publications for CDON Gene

  1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PMID: 9214393) Kang J.-S. … Krauss R.S. (J. Cell Biol. 1997) 2 3 4 23 67
  2. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. (PMID: 19470755) Bae G.U. … Kang J.S. (Mol. Cell. Biol. 2009) 3 23
  3. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PMID: 12634428) Kang J.-S. … Krauss R.S. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23
  4. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. (PMID: 12720294) Wegorzewska M. … Kang J.S. (Mol. Carcinog. 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CDON Gene

Sources for CDON Gene

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