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Aliases for CDON Gene

Aliases for CDON Gene

  • Cell Adhesion Associated, Oncogene Regulated 2 3 5
  • Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes 2 3
  • CDO 3 4
  • Surface Glycoprotein, Ig Superfamily Member 3
  • Cdon Homolog (Mouse) 2
  • Cdon Homolog 3
  • CDON1 3
  • HPE11 3
  • ORCAM 3

External Ids for CDON Gene

Previous GeneCards Identifiers for CDON Gene

  • GC11M127831
  • GC11M127343
  • GC11M125866
  • GC11M125368
  • GC11M125335
  • GC11M121768

Summaries for CDON Gene

Entrez Gene Summary for CDON Gene

  • This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

GeneCards Summary for CDON Gene

CDON (Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Diseases associated with CDON include Holoprosencephaly 11 and Pituitary Stalk Interruption Syndrome. Among its related pathways are Ectoderm Differentiation and Signaling by Hedgehog. An important paralog of this gene is BOC.

UniProtKB/Swiss-Prot for CDON Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Gene Wiki entry for CDON Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDON Gene

Genomics for CDON Gene

Regulatory Elements for CDON Gene

Enhancers for CDON Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G126122 1.1 FANTOM5 ENCODE dbSUPER 11 -60.4 -60384 2.4 JUND PRDM6 MYNN FOS NFE2 WT1 ZKSCAN1 ENSG00000254833 CDON ENSG00000254790 LOC105369591 ENSG00000261257
GH11G126091 0.8 ENCODE 11.6 -28.7 -28746 0.2 TFAP4 FOXA2 CEBPG FEZF1 BMI1 ZNF384 RAD21 ZFHX2 GATA3 PATZ1 CDON ENSG00000261257 NAP1L1P1
GH11G126060 1.4 Ensembl ENCODE 6.1 +1.0 965 3.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 FEZ1 CDON PIR48177
GH11G126135 1.4 Ensembl ENCODE dbSUPER 6.1 -75.5 -75482 5.8 FOXA2 SIN3A KLF17 INSM2 FEZF1 ZNF2 RAD21 ZSCAN5C FOS MIXL1 CDON FAM118B FOXRED1 SRPRA LOC105369591 ENSG00000261257
GH11G126034 0.7 ENCODE 11.7 +28.4 28386 1.4 RING1 PHF8 MXI1 RNF2 NRF1 MAX RBBP5 NR2F2 POLR2A HDAC2 CDON DDX25 PUS3 PIR48177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDON on UCSC Golden Path with GeneCards custom track

Promoters for CDON Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CDON Gene

125,955,796 bp from pter
126,063,335 bp from pter
107,540 bases
Minus strand

Genomic View for CDON Gene

Genes around CDON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDON Gene

Proteins for CDON Gene

  • Protein details for CDON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Protein Accession:
    Secondary Accessions:
    • O14631

    Protein attributes for CDON Gene

    1287 amino acids
    Molecular mass:
    139147 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.

    Three dimensional structures from OCA and Proteopedia for CDON Gene

    Alternative splice isoforms for CDON Gene


neXtProt entry for CDON Gene

Post-translational modifications for CDON Gene

  • N-glycosylated.
  • Glycosylation at Asn88, posLast=100100, Asn180, Asn287, posLast=294294, posLast=342342, Asn427, posLast=570570, Asn873, and Ser932
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDON Gene

Domains & Families for CDON Gene

Suggested Antigen Peptide Sequences for CDON Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDON: view

No data available for UniProtKB/Swiss-Prot for CDON Gene

Function for CDON Gene

Molecular function for CDON Gene

UniProtKB/Swiss-Prot Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

Gene Ontology (GO) - Molecular Function for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11782431
genes like me logo Genes that share ontologies with CDON: view
genes like me logo Genes that share phenotypes with CDON: view

Human Phenotype Ontology for CDON Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDON Gene

MGI Knock Outs for CDON:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDON

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CDON Gene

Localization for CDON Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDON Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDON gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 colocalizes_with extracellular matrix TAS 22261194
genes like me logo Genes that share ontologies with CDON: view

Pathways & Interactions for CDON Gene

genes like me logo Genes that share pathways with CDON: view

SIGNOR curated interactions for CDON Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007155 cell adhesion TAS 9214393
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with CDON: view

Drugs & Compounds for CDON Gene

No Compound Related Data Available

Transcripts for CDON Gene

Unigene Clusters for CDON Gene

Cell adhesion associated, oncogene regulated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDON Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for CDON Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDON Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDON Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for CDON Gene

This gene is overexpressed in Testis (33.0), Plasma (21.7), and Vitreous humor (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDON Gene

Protein tissue co-expression partners for CDON Gene

NURSA nuclear receptor signaling pathways regulating expression of CDON Gene:


SOURCE GeneReport for Unigene cluster for CDON Gene:


Evidence on tissue expression from TISSUES for CDON Gene

  • Nervous system(4.5)
  • Lung(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CDON Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • brain
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
  • hair
  • skin
genes like me logo Genes that share expression patterns with CDON: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDON Gene

Orthologs for CDON Gene

This gene was present in the common ancestor of animals.

Orthologs for CDON Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDON 34 35
  • 98.81 (n)
(Canis familiaris)
Mammalia CDON 34 35
  • 86.95 (n)
(Bos Taurus)
Mammalia CDON 34 35
  • 84.84 (n)
(Mus musculus)
Mammalia Cdon 34 16 35
  • 82.43 (n)
(Rattus norvegicus)
Mammalia Cdon 34
  • 81.49 (n)
(Monodelphis domestica)
Mammalia CDON 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CDON 35
  • 70 (a)
(Gallus gallus)
Aves CDON 35
  • 62 (a)
(Anolis carolinensis)
Reptilia CDON 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdon 34
  • 62.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdon-A 34
(Danio rerio)
Actinopterygii cdon 35
  • 49 (a)
wufa10c02 34
fruit fly
(Drosophila melanogaster)
Insecta boi 35
  • 20 (a)
ihog 35
  • 20 (a)
CG6490 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
-- 35
  • 30 (a)
Species where no ortholog for CDON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDON Gene

Gene Tree for CDON (if available)
Gene Tree for CDON (if available)

Paralogs for CDON Gene

Variants for CDON Gene

Sequence variations from dbSNP and Humsavar for CDON Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs139323558 Holoprosencephaly 11 (HPE11) [MIM:614226] 126,001,806(+) GCCCA(A/C/T)GGGTG nc-transcript-variant, reference, missense
rs145983470 Likely benign, Holoprosencephaly 11 (HPE11) [MIM:614226] 126,001,826(+) CCTGG(C/G)TGTTT nc-transcript-variant, reference, missense
rs369673018 Pathogenic, Holoprosencephaly 11 (HPE11) [MIM:614226] 125,984,049(+) GGTAC(G/T)CAAGT nc-transcript-variant, reference, missense
rs387906995 Pathogenic, Holoprosencephaly 11 (HPE11) [MIM:614226] 126,001,812(-) CCTCT(C/G)CACCC nc-transcript-variant, reference, missense
rs387906996 Pathogenic, Holoprosencephaly 11 (HPE11) [MIM:614226] 125,997,230(-) TTCAG(A/T)GGAAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDON Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
esv3627998 CNV loss 21293372
nsv1040649 CNV loss 25217958
nsv535 CNV deletion 18451855
nsv556525 CNV gain 21841781
nsv819513 CNV loss 19587683

Variation tolerance for CDON Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.65; 86.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDON Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDON Gene

Disorders for CDON Gene

MalaCards: The human disease database

(13) MalaCards diseases for CDON Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly 11
  • hpe11
pituitary stalk interruption syndrome
  • ectopic neurohypophysis
midline interhemispheric variant of holoprosencephaly
  • mih
septopreoptic holoprosencephaly
  • septopreoptic hpe
single median maxillary central incisor
  • solitary median maxillary central incisor
- elite association - COSMIC cancer census association via MalaCards
Search CDON in MalaCards View complete list of genes associated with diseases


  • Holoprosencephaly 11 (HPE11) [MIM:614226]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269 PubMed:21802063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDON

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDON: view

No data available for Genatlas for CDON Gene

Publications for CDON Gene

  1. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. (PMID: 9214393) Kang J.-S. … Krauss R.S. (J. Cell Biol. 1997) 2 3 4 22 64
  2. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. (PMID: 21802063) Bae G.U. … Krauss R.S. (Am. J. Hum. Genet. 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PMID: 20519495) Kavran J.M. … Leahy D.J. (J. Biol. Chem. 2010) 3 4 64
  5. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. (PMID: 19470755) Bae G.U. … Kang J.S. (Mol. Cell. Biol. 2009) 3 22 64

Products for CDON Gene

Sources for CDON Gene

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