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Aliases for PBX3 Gene

Aliases for PBX3 Gene

  • Pre-B-Cell Leukemia Homeobox 3 2 3
  • Pre-B-Cell Leukemia Transcription Factor 3 2
  • Homeobox Protein PBX3 4

External Ids for PBX3 Gene

Previous GeneCards Identifiers for PBX3 Gene

  • GC09P119624
  • GC09P120156
  • GC09P121963
  • GC09P123885
  • GC09P125589
  • GC09P127549
  • GC09P128508
  • GC09P098122
  • GC09P128511
  • GC09P128513

Summaries for PBX3 Gene

GeneCards Summary for PBX3 Gene

PBX3 (Pre-B-Cell Leukemia Homeobox 3) is a Protein Coding gene. Diseases associated with PBX3 include childhood pilocytic astrocytoma and leukemia, acute myeloid. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PBX2.

UniProtKB/Swiss-Prot for PBX3 Gene

  • Transcriptional activator that binds the sequence 5-ATCAATCAA-3

Gene Wiki entry for PBX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX3 Gene

Genomics for PBX3 Gene

Regulatory Elements for PBX3 Gene

Genomic Location for PBX3 Gene

Chromosome:
9
Start:
125,747,338 bp from pter
End:
125,967,377 bp from pter
Size:
220,040 bases
Orientation:
Plus strand

Genomic View for PBX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PBX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PBX3 Gene

Proteins for PBX3 Gene

  • Protein details for PBX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40426-PBX3_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 3
    Protein Accession:
    P40426
    Secondary Accessions:
    • E9PB27
    • Q5JSA0
    • Q5JSA1
    • Q5VXL3
    • Q96PF9
    • Q96PG0

    Protein attributes for PBX3 Gene

    Size:
    434 amino acids
    Molecular mass:
    47190 Da
    Quaternary structure:
    • Interacts with PBXIP1.

    Alternative splice isoforms for PBX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PBX3 Gene

Proteomics data for PBX3 Gene at MOPED

Post-translational modifications for PBX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PBX3 Gene

Domains & Families for PBX3 Gene

Gene Families for PBX3 Gene

Protein Domains for PBX3 Gene

Graphical View of Domain Structure for InterPro Entry

P40426

UniProtKB/Swiss-Prot:

PBX3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/PBX homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX3: view

Function for PBX3 Gene

Molecular function for PBX3 Gene

GENATLAS Biochemistry:
transcription factor,with an atypical homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds the sequence 5-ATCAATCAA-3

Gene Ontology (GO) - Molecular Function for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PBX3: view
genes like me logo Genes that share phenotypes with PBX3: view

Animal Models for PBX3 Gene

MGI Knock Outs for PBX3:

Animal Model Products

Targeted motifs for PBX3 Gene
HOMER Transcription Factor Regulatory Elements motif PBX3
  • Consensus sequence: CCTGTCAATCAN Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PBX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for PBX3 Gene

Localization for PBX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PBX3 Gene COMPARTMENTS Subcellular localization image for PBX3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with PBX3: view

Pathways & Interactions for PBX3 Gene

genes like me logo Genes that share pathways with PBX3: view

Pathways by source for PBX3 Gene

1 KEGG pathway for PBX3 Gene

Gene Ontology (GO) - Biological Process for PBX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007387 anterior compartment pattern formation TAS 1682799
GO:0007388 posterior compartment specification TAS 1682799
genes like me logo Genes that share ontologies with PBX3: view

No data available for SIGNOR curated interactions for PBX3 Gene

Drugs & Compounds for PBX3 Gene

No Compound Related Data Available

Transcripts for PBX3 Gene

Unigene Clusters for PBX3 Gene

Pre-B-cell leukemia homeobox 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PBX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PBX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - - - - - - -
SP2:
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - - - - - -

Relevant External Links for PBX3 Gene

GeneLoc Exon Structure for
PBX3
ECgene alternative splicing isoforms for
PBX3

Expression for PBX3 Gene

mRNA expression in normal human tissues for PBX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PBX3 Gene

This gene is overexpressed in Ovary (14.2), Uterus (11.4), Fetal gut (10.9), Fetal ovary (7.6), Islet of Langerhans (6.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PBX3 Gene



SOURCE GeneReport for Unigene cluster for PBX3 Gene Hs.428027

mRNA Expression by UniProt/SwissProt for PBX3 Gene

P40426-PBX3_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expression patterns with PBX3: view

Protein tissue co-expression partners for PBX3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PBX3 Gene

Orthologs for PBX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PBX3 35
  • 97.2 (n)
  • 99.46 (a)
PBX3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pbx3 35
  • 96.01 (n)
  • 99.77 (a)
Pbx3 16
Pbx3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PBX3 35
  • 96.01 (n)
  • 94.93 (a)
PBX3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pbx3 35
  • 95.31 (n)
  • 99.77 (a)
cow
(Bos Taurus)
Mammalia PBX3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBX3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PBX3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PBX3 35
  • 91.53 (n)
  • 99.54 (a)
PBX3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PBX3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pbx3 35
  • 83.37 (n)
  • 95.38 (a)
Str.11416 35
zebrafish
(Danio rerio)
Actinopterygii pbx3a 35
  • 74.03 (n)
  • 83.37 (a)
pbx3b 35
pbx3a 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta exd 37
  • 78 (a)
exd 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-20 37
  • 65 (a)
ceh-40 37
  • 40 (a)
ceh-20 36
  • 56 (a)
ManyToMany
ceh-40 36
  • 34 (a)
ManyToMany
ceh-60 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 36
  • 60 (a)
OneToMany
Species with no ortholog for PBX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PBX3 Gene

ENSEMBL:
Gene Tree for PBX3 (if available)
TreeFam:
Gene Tree for PBX3 (if available)

Paralogs for PBX3 Gene

Paralogs for PBX3 Gene

(6) SIMAP similar genes for PBX3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PBX3: view

Variants for PBX3 Gene

Sequence variations from dbSNP and Humsavar for PBX3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs871602 -- 125,881,454(+) AACTT(C/T)TGGCA intron-variant
rs872524 -- 125,961,540(-) AGAAA(A/C/T)GCCCC intron-variant
rs10987001 -- 125,876,770(+) TATCT(C/T)ACTTT intron-variant
rs10987000 -- 125,876,622(+) CTGTT(A/G)TCAGT intron-variant
rs10986998 -- 125,874,645(+) TTCAC(C/T)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PBX3 Gene

Variant ID Type Subtype PubMed ID
nsv825078 CNV Gain 20364138
nsv825079 CNV Gain 20364138
esv26440 CNV Loss 19812545
esv1270380 CNV Insertion 17803354
dgv8281n71 CNV Loss 21882294
nsv6715 CNV Insertion 18451855
esv987876 CNV Insertion 20482838
esv2678016 CNV Deletion 23128226
esv268501 CNV Insertion 20981092
esv2739043 CNV Deletion 23290073
nsv416676 CNV Loss 16902084

Variation tolerance for PBX3 Gene

Residual Variation Intolerance Score: 18.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBX3 Gene

HapMap Linkage Disequilibrium report
PBX3
Human Gene Mutation Database (HGMD)
PBX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBX3 Gene

Disorders for PBX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PBX3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood pilocytic astrocytoma
  • pediatric pilocytic astrocytoma
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search PBX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PBX3

Genetic Association Database (GAD)
PBX3
Human Genome Epidemiology (HuGE) Navigator
PBX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBX3
genes like me logo Genes that share disorders with PBX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBX3 Gene

Publications for PBX3 Gene

  1. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PMID: 1682799) Monica K. … Cleary M.L. (Mol. Cell. Biol. 1991) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia. (PMID: 25266220) HA!jkovA! H. … BeneA! V. (J Hematol Oncol 2014) 67
  5. PBX3 is overexpressed in gastric cancer and regulates cell proliferation. (PMID: 24375258) Li Y. … Xu H. (Tumour Biol. 2013) 67

Products for PBX3 Gene

Sources for PBX3 Gene

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