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Aliases for ATP5C1 Gene

Aliases for ATP5C1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1 2 3
  • ATP5CL1 3 4 6
  • ATP5C 3 4 6
  • F-ATPase Gamma Subunit 3 4
  • Mitochondrial ATP Synthase, Gamma Subunit 1 3
  • ATP Synthase Subunit Gamma, Mitochondrial 3
  • ATP Synthase Gamma Chain, Mitochondrial 3

External Ids for ATP5C1 Gene

Previous Symbols for ATP5C1 Gene

  • ATP5CL1
  • ATP5C

Summaries for ATP5C1 Gene

Entrez Gene Summary for ATP5C1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5C1 Gene

ATP5C1 (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ATPase activity and proton-transporting ATPase activity, rotational mechanism.

UniProtKB/Swiss-Prot for ATP5C1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Wiki entry for ATP5C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5C1 Gene

Genomics for ATP5C1 Gene

Genomic Location for ATP5C1 Gene

Start:
7,788,129 bp from pter
End:
7,807,815 bp from pter
Size:
19,687 bases
Orientation:
Plus strand

Genomic View for ATP5C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP5C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5C1 Gene

Regulatory Elements for ATP5C1 Gene

Proteins for ATP5C1 Gene

  • Protein details for ATP5C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36542-ATPG_HUMAN
    Recommended name:
    ATP synthase subunit gamma, mitochondrial
    Protein Accession:
    P36542
    Secondary Accessions:
    • A8KA31
    • Q5VYP3
    • Q6I9V2
    • Q96AS8

    Protein attributes for ATP5C1 Gene

    Size:
    298 amino acids
    Molecular mass:
    32996 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5C1 Gene

Proteomics data for ATP5C1 Gene at MOPED

Post-translational modifications for ATP5C1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys49, Lys55, Lys112, Lys136, and Lys270

Other Protein References for ATP5C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5C1 Gene

Domains for ATP5C1 Gene

Gene Families for ATP5C1 Gene

HGNC:
  • FATP :Mitochondrial respiratory chain complex / Complex V
  • F1ATP :ATPases / F-type
IUPHAR :

UniProtKB/Swiss-Prot:

ATPG_HUMAN
Family:
  • Belongs to the ATPase gamma chain family.:
    • P36542
genes like me logo Genes that share domains with ATP5C1: view

Function for ATP5C1 Gene

Molecular function for ATP5C1 Gene

GENATLAS Biochemistry: ATP synthase H+ transporting,mitochondrial matrix (F1 segment),gamma subunit isoform 1,mainly expressed in heart,located in the mitochondrial matrix,complex V of oxidative phosphorylation (OXPHOS) with an alternative isoform in the liver differing by a deletion of an Asp(233)
UniProtKB/Swiss-Prot Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Gene Ontology (GO) - Molecular Function for ATP5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 contributes_to ATPase activity NAS 8227057
GO:0022857 transmembrane transporter activity IC 12110673
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA --
GO:0046961 proton-transporting ATPase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP5C1: view

miRNA for ATP5C1 Gene

miRTarBase miRNAs that target ATP5C1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP5C1 Gene

Localization for ATP5C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5C1 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5C1 Gene COMPARTMENTS Subcellular localization image for ATP5C1 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATP5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS 8227057
GO:0005739 mitochondrion NAS 12887009
GO:0005743 mitochondrial inner membrane ISS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ATP5C1: view

Pathways for ATP5C1 Gene

genes like me logo Genes that share pathways with ATP5C1: view

Gene Ontology (GO) - Biological Process for ATP5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation NAS 8227057
GO:0006200 obsolete ATP catabolic process --
GO:0006754 ATP biosynthetic process NAS 8227057
GO:0015986 ATP synthesis coupled proton transport --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with ATP5C1: view

Compounds for ATP5C1 Gene

(4) HMDB Compounds for ATP5C1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(5) Drugbank Compounds for ATP5C1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-ACETYL-2-CARBOXYPIPERIDINE
target
AUROVERTIN B
target
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
target
PICEATANNOL
target
Quercetin
117-39-5 target
genes like me logo Genes that share compounds with ATP5C1: view

Transcripts for ATP5C1 Gene

Unigene Clusters for ATP5C1 Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5C1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for ATP5C1 Gene

GeneLoc Exon Structure for
ATP5C1
ECgene alternative splicing isoforms for
ATP5C1

Expression for ATP5C1 Gene

mRNA expression in normal human tissues for ATP5C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP5C1 Gene

This gene is overexpressed in Heart - Left Ventricle (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5C1 Gene

SOURCE GeneReport for Unigene cluster for ATP5C1 Gene Hs.271135

mRNA Expression by UniProt/SwissProt for ATP5C1 Gene

P36542-ATPG_HUMAN
Tissue specificity: Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta
genes like me logo Genes that share expressions with ATP5C1: view

Orthologs for ATP5C1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5C1 36
  • 99.78 (n)
  • 100 (a)
ATP5C1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5C1 36
  • 87.58 (n)
  • 91.61 (a)
ATP5C1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
ATP5C1 36
  • 90.49 (n)
  • 95.64 (a)
mouse
(Mus musculus)
Mammalia Atp5c1 36
  • 87.47 (n)
  • 91.28 (a)
Atp5c1 16
Atp5c1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5C1 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp5c1 36
  • 85.35 (n)
  • 90.27 (a)
chicken
(Gallus gallus)
Aves ATP5C1 36
  • 78 (n)
  • 82.99 (a)
ATP5C1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5C1 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5c1 36
  • 75.11 (n)
  • 82.53 (a)
Str.4048 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8471 36
zebrafish
(Danio rerio)
Actinopterygii atp5c1 36
  • 71 (n)
  • 79.45 (a)
atp5c1 37
  • 78 (a)
OneToOne
wufk34c05 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007966 36
  • 57.54 (n)
  • 57.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-gamma 36
  • 57.39 (n)
  • 60.07 (a)
ATPsyn-gamma 37
  • 56 (a)
OneToOne
ATPsyn-gamma 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.18 36
  • 59.12 (n)
  • 59.85 (a)
Y69A2AR.18 37
  • 41 (a)
OneToOne
Y69A2AR.18a 38
  • 57 (a)
Y69A2AR.18b 38
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL176W 36
  • 50.49 (n)
  • 40.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP3 36
  • 52.45 (n)
  • 41.18 (a)
ATP3 37
  • 38 (a)
OneToOne
ATP3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06886g 36
  • 54.53 (n)
  • 45.22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATP3 36
  • 50.92 (n)
  • 39.11 (a)
rice
(Oryza sativa)
Liliopsida Os.10703 36
Os10g0320400 36
  • 50.78 (n)
  • 41.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09119 36
  • 49.81 (n)
  • 44.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp3 36
  • 50.06 (n)
  • 39.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4089 37
  • 50 (a)
OneToOne
Species with no ortholog for ATP5C1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5C1 Gene

ENSEMBL:
Gene Tree for ATP5C1 (if available)
TreeFam:
Gene Tree for ATP5C1 (if available)

Paralogs for ATP5C1 Gene

Pseudogenes.org Pseudogenes for ATP5C1 Gene

genes like me logo Genes that share paralogs with ATP5C1: view

No data available for Paralogs for ATP5C1 Gene

Variants for ATP5C1 Gene

Sequence variations from dbSNP and Humsavar for ATP5C1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4655 -- 7,807,725(+) GAAAC(C/T)GTTCC utr-variant-3-prime
rs762452 -- 7,803,627(+) ACTTT(A/G)ATGTT intron-variant
rs762453 -- 7,803,806(+) AAAAC(A/G)TGTAG intron-variant
rs914609 -- 7,804,189(+) CAGAG(C/T)GCAGA intron-variant
rs932971 -- 7,802,232(+) CCTTC(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5C1 Gene

Variant ID Type Subtype PubMed ID
esv2671165 CNV Deletion 23128226

Relevant External Links for ATP5C1 Gene

HapMap Linkage Disequilibrium report
ATP5C1

Disorders for ATP5C1 Gene

Relevant External Links for ATP5C1

Genetic Association Database (GAD)
ATP5C1
Human Genome Epidemiology (HuGE) Navigator
ATP5C1
genes like me logo Genes that share disorders with ATP5C1: view

No data available for UniProtKB/Swiss-Prot for ATP5C1 Gene

Publications for ATP5C1 Gene

  1. Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing. (PMID: 8227057) Matsuda C. … Kagawa Y. (J. Biol. Chem. 1993) 2 3 4 23
  2. Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. (PMID: 8168843) Jabs E.W. … Pedersen P.L. (Hum. Genet. 1994) 2 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP5C1 Gene

Sources for ATP5C1 Gene

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