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Aliases for ATP5C1 Gene

Aliases for ATP5C1 Gene

  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1 2 3 5
  • F-ATPase Gamma Subunit 3 4
  • ATP5CL1 3 4
  • ATP5C 3 4
  • Mitochondrial ATP Synthase, Gamma Subunit 1 3
  • ATP Synthase Gamma Chain, Mitochondrial 3

External Ids for ATP5C1 Gene

Previous HGNC Symbols for ATP5C1 Gene

  • ATP5CL1
  • ATP5C

Previous GeneCards Identifiers for ATP5C1 Gene

  • GC10P007774
  • GC10P007980
  • GC10P007834
  • GC10P007870
  • GC10P007830

Summaries for ATP5C1 Gene

Entrez Gene Summary for ATP5C1 Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5C1 Gene

ATP5C1 (ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Gamma Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include poly(A) RNA binding and transmembrane transporter activity.

UniProtKB/Swiss-Prot for ATP5C1 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Wiki entry for ATP5C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5C1 Gene

Genomics for ATP5C1 Gene

Regulatory Elements for ATP5C1 Gene

Promoters for ATP5C1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP5C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP5C1 Gene

Chromosome:
10
Start:
7,788,129 bp from pter
End:
7,807,815 bp from pter
Size:
19,687 bases
Orientation:
Plus strand

Genomic View for ATP5C1 Gene

Genes around ATP5C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5C1 Gene

Proteins for ATP5C1 Gene

  • Protein details for ATP5C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36542-ATPG_HUMAN
    Recommended name:
    ATP synthase subunit gamma, mitochondrial
    Protein Accession:
    P36542
    Secondary Accessions:
    • A8KA31
    • Q5VYP3
    • Q6I9V2
    • Q96AS8

    Protein attributes for ATP5C1 Gene

    Size:
    298 amino acids
    Molecular mass:
    32996 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

    Alternative splice isoforms for ATP5C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP5C1 Gene

Proteomics data for ATP5C1 Gene at MOPED

Post-translational modifications for ATP5C1 Gene

  • Ubiquitination at Lys 49, Lys 55, Lys 112, Lys 136, and Lys 270
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5C1 Gene

Antibody Products

No data available for DME Specific Peptides for ATP5C1 Gene

Domains & Families for ATP5C1 Gene

Suggested Antigen Peptide Sequences for ATP5C1 Gene

Graphical View of Domain Structure for InterPro Entry

P36542

UniProtKB/Swiss-Prot:

ATPG_HUMAN :
  • Belongs to the ATPase gamma chain family.
Family:
  • Belongs to the ATPase gamma chain family.
genes like me logo Genes that share domains with ATP5C1: view

Function for ATP5C1 Gene

Molecular function for ATP5C1 Gene

GENATLAS Biochemistry:
ATP synthase H+ transporting,mitochondrial matrix (F1 segment),gamma subunit isoform 1,mainly expressed in heart,located in the mitochondrial matrix,complex V of oxidative phosphorylation (OXPHOS) with an alternative isoform in the liver differing by a deletion of an Asp(233)
UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
genes like me logo Genes that share phenotypes with ATP5C1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5C1 Gene

Localization for ATP5C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5C1 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP5C1 Gene COMPARTMENTS Subcellular localization image for ATP5C1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATP5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043209 myelin sheath IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ATP5C1: view

Pathways & Interactions for ATP5C1 Gene

genes like me logo Genes that share pathways with ATP5C1: view

Gene Ontology (GO) - Biological Process for ATP5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ATP5C1: view

No data available for SIGNOR curated interactions for ATP5C1 Gene

Drugs & Compounds for ATP5C1 Gene

(6) Drugs for ATP5C1 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
1-ACETYL-2-CARBOXYPIPERIDINE Experimental Pharma Target 0
AUROVERTIN B Experimental Pharma Target 0
N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Experimental Pharma Target 0
Piceatannol Experimental Pharma Target p56lck/Syk inhibitor, Inhibits TNF-induced NF-kappaB activation 0

(3) Additional Compounds for ATP5C1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATP5C1: view

Transcripts for ATP5C1 Gene

Unigene Clusters for ATP5C1 Gene

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5C1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for ATP5C1 Gene

GeneLoc Exon Structure for
ATP5C1
ECgene alternative splicing isoforms for
ATP5C1

Expression for ATP5C1 Gene

mRNA expression in normal human tissues for ATP5C1 Gene

mRNA differential expression in normal tissues according to GTEx for ATP5C1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.2).

Protein differential expression in normal tissues from HIPED for ATP5C1 Gene

This gene is overexpressed in Heart (7.3) and Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP5C1 Gene



SOURCE GeneReport for Unigene cluster for ATP5C1 Gene Hs.271135

mRNA Expression by UniProt/SwissProt for ATP5C1 Gene

P36542-ATPG_HUMAN
Tissue specificity: Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta.
genes like me logo Genes that share expression patterns with ATP5C1: view

Protein tissue co-expression partners for ATP5C1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP5C1 Gene

Orthologs for ATP5C1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP5C1 35
  • 87.58 (n)
  • 91.61 (a)
ATP5C1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5C1 35
  • 90.49 (n)
  • 95.64 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5c1 35
  • 87.47 (n)
  • 91.28 (a)
Atp5c1 16
Atp5c1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP5C1 35
  • 99.78 (n)
  • 100 (a)
ATP5C1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp5c1 35
  • 85.35 (n)
  • 90.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP5C1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATP5C1 35
  • 78 (n)
  • 82.99 (a)
ATP5C1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5C1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5c1 35
  • 75.11 (n)
  • 82.53 (a)
Str.4048 35
zebrafish
(Danio rerio)
Actinopterygii atp5c1 35
  • 71 (n)
  • 79.45 (a)
wufk34c05 35
atp5c1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8471 35
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-gamma 37
  • 58 (a)
ATPsyn-gamma 35
  • 57.39 (n)
  • 60.07 (a)
ATPsyn-gamma 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007966 35
  • 57.54 (n)
  • 57.3 (a)
worm
(Caenorhabditis elegans)
Secernentea Y69A2AR.18a 37
  • 57 (a)
Y69A2AR.18b 37
  • 51 (a)
CELE_Y69A2AR.18 35
  • 59.12 (n)
  • 59.85 (a)
Y69A2AR.18 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL176W 35
  • 50.49 (n)
  • 40.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06886g 35
  • 54.53 (n)
  • 45.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP3 35
  • 52.45 (n)
  • 41.18 (a)
ATP3 36
  • 38 (a)
OneToOne
ATP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATP3 35
  • 50.92 (n)
  • 39.11 (a)
rice
(Oryza sativa)
Liliopsida Os.10703 35
Os10g0320400 35
  • 50.78 (n)
  • 41.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09119 35
  • 49.81 (n)
  • 44.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp3 35
  • 50.06 (n)
  • 39.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4089 36
  • 50 (a)
OneToOne
Species with no ortholog for ATP5C1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5C1 Gene

ENSEMBL:
Gene Tree for ATP5C1 (if available)
TreeFam:
Gene Tree for ATP5C1 (if available)

Paralogs for ATP5C1 Gene

Pseudogenes.org Pseudogenes for ATP5C1 Gene

genes like me logo Genes that share paralogs with ATP5C1: view

No data available for Paralogs for ATP5C1 Gene

Variants for ATP5C1 Gene

Sequence variations from dbSNP and Humsavar for ATP5C1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1244414 -- 7,794,141(+) gtgtg(C/T)gggca intron-variant
rs1244415 -- 7,794,560(+) acttt(A/T)tcatg intron-variant
rs1244416 -- 7,795,226(+) CCTGA(A/T)CATGA intron-variant
rs1244417 -- 7,795,942(+) GGATT(C/T)GCGCC intron-variant
rs1244418 -- 7,796,245(-) CACAA(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5C1 Gene

Variant ID Type Subtype PubMed ID
esv2671165 CNV Deletion 23128226

Variation tolerance for ATP5C1 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP5C1 Gene

HapMap Linkage Disequilibrium report
ATP5C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5C1 Gene

Disorders for ATP5C1 Gene

Relevant External Links for ATP5C1

Genetic Association Database (GAD)
ATP5C1
Human Genome Epidemiology (HuGE) Navigator
ATP5C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP5C1

No disorders were found for ATP5C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5C1 Gene

Publications for ATP5C1 Gene

  1. Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing. (PMID: 8227057) Matsuda C. … Kagawa Y. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. (PMID: 8168843) Jabs E.W. … Pedersen P.L. (Hum. Genet. 1994) 2 3
  3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for ATP5C1 Gene

Sources for ATP5C1 Gene

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