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Aliases for PBX2 Gene

Aliases for PBX2 Gene

  • PBX Homeobox 2 2 3 5
  • Pre-B-Cell Leukemia Transcription Factor 2 2 3
  • Pre-B-Cell Leukemia Homeobox 2 2 3
  • Homeobox Protein PBX2 3 4
  • G17 3 4
  • XXbac-BPG300A18.13 3
  • Homeobox 12 3
  • Protein G17 4
  • PBX2MHC 3
  • HOX12 3

External Ids for PBX2 Gene

Previous GeneCards Identifiers for PBX2 Gene

  • GC06M032179
  • GC06M031923
  • GC06M032223
  • GC06M032260
  • GC06M031907
  • GC06M032151
  • GC06M032153
  • GC06M032158

Summaries for PBX2 Gene

Entrez Gene Summary for PBX2 Gene

  • This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for PBX2 Gene

PBX2 (PBX Homeobox 2) is a Protein Coding gene. Diseases associated with PBX2 include Duodenal Gastrinoma and Pancreatic Gastrinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is PBX3.

UniProtKB/Swiss-Prot for PBX2 Gene

  • Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Gene Wiki entry for PBX2 Gene

Additional gene information for PBX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PBX2 Gene

Genomics for PBX2 Gene

Regulatory Elements for PBX2 Gene

Enhancers for PBX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H032965 1.5 ENCODE dbSUPER 52.3 -780.5 -780483 10 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A PPARGC1A BRD2 LEMD2 VPS52 RXRB ATF6B HCG25 RING1 DAXX WDR46 PPT2
GH06H031725 1.6 Ensembl ENCODE dbSUPER 43.5 +461.6 461606 5 HNRNPUL1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B DDX39B LY6G5B ATF6B LSM2 SKIV2L PBX2 CSNK2B NFKBIL1 DXO MSH5
GH06H031538 1.4 ENCODE dbSUPER 39.9 +649.0 649048 4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MCM3 PPARGC1A MEF2D ATF6B LSM2 LY6G5B DDX39B MDC1 PPP1R10 NRM DHX16 MSH5 TCF19
GH06H031733 1.9 FANTOM5 ENCODE dbSUPER 24.9 +452.7 452732 8 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC ZC3H11A LY6G5B ATF6B DDX39B LSM2 CSNK2B GPANK1 VARS NFKBIL1 SKIV2L MSH5
GH06H031829 1.4 ENCODE dbSUPER 29.9 +356.0 356030 9 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A MEF2D GLIS1 NBN ATF6B LY6G5B DDX39B LSM2 CSNK2B MSH5 SKIV2L BAG6 VARS GPANK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PBX2 on UCSC Golden Path with GeneCards custom track

Promoters for PBX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320273 186 2001 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for PBX2 Gene

Chromosome:
6
Start:
32,184,733 bp from pter
End:
32,190,186 bp from pter
Size:
5,454 bases
Orientation:
Minus strand

Genomic View for PBX2 Gene

Genes around PBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PBX2 Gene

  • Protein details for PBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40425-PBX2_HUMAN
    Recommended name:
    Pre-B-cell leukemia transcription factor 2
    Protein Accession:
    P40425
    Secondary Accessions:
    • A2BFJ2

    Protein attributes for PBX2 Gene

    Size:
    430 amino acids
    Molecular mass:
    45881 Da
    Quaternary structure:
    • Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1.

neXtProt entry for PBX2 Gene

Post-translational modifications for PBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PBX2 Gene

Domains & Families for PBX2 Gene

Gene Families for PBX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for PBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40425

UniProtKB/Swiss-Prot:

PBX2_HUMAN :
  • Belongs to the TALE/PBX homeobox family.
Family:
  • Belongs to the TALE/PBX homeobox family.
genes like me logo Genes that share domains with PBX2: view

Function for PBX2 Gene

Molecular function for PBX2 Gene

GENATLAS Biochemistry:
transcription factor,with a homeo domain,homologous to PBX1,expressed in most tissues,fetal and adult,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors
UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds the sequence 5-ATCAATCAA-3. Activates transcription of PF4 in complex with MEIS1.

Phenotypes From GWAS Catalog for PBX2 Gene

Gene Ontology (GO) - Molecular Function for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 12054735
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with PBX2: view
genes like me logo Genes that share phenotypes with PBX2: view

Animal Models for PBX2 Gene

MGI Knock Outs for PBX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PBX2
  • Applied Biological Materials Clones for PBX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PBX2 Gene

Localization for PBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PBX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PBX2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18973687
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with PBX2: view

Pathways & Interactions for PBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0009954 proximal/distal pattern formation IEA --
GO:0030326 embryonic limb morphogenesis IEA --
genes like me logo Genes that share ontologies with PBX2: view

No data available for Pathways by source and SIGNOR curated interactions for PBX2 Gene

Drugs & Compounds for PBX2 Gene

No Compound Related Data Available

Transcripts for PBX2 Gene

Unigene Clusters for PBX2 Gene

Pre-B-cell leukemia homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PBX2
  • Applied Biological Materials Clones for PBX2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PBX2 Gene

No ASD Table

Relevant External Links for PBX2 Gene

GeneLoc Exon Structure for
PBX2
ECgene alternative splicing isoforms for
PBX2

Expression for PBX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PBX2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for PBX2 Gene

This gene is overexpressed in Blymphocyte (40.7) and CD8 Tcells (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PBX2 Gene



Protein tissue co-expression partners for PBX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PBX2 Gene:

PBX2

SOURCE GeneReport for Unigene cluster for PBX2 Gene:

Hs.509545

mRNA Expression by UniProt/SwissProt for PBX2 Gene:

P40425-PBX2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for PBX2 Gene

  • Liver(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PBX2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PBX2 Gene

Orthologs for PBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PBX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PBX2 33 34
  • 99.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PBX2 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PBX2 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PBX2 33 34
  • 93.41 (n)
dog
(Canis familiaris)
Mammalia PBX2 33 34
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Pbx2 33
  • 91.47 (n)
mouse
(Mus musculus)
Mammalia Pbx2 33 16 34
  • 90.93 (n)
lizard
(Anolis carolinensis)
Reptilia PBX2 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pbx2 33
  • 78.28 (n)
Str.6454 33
zebrafish
(Danio rerio)
Actinopterygii pbx2 34
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta exd 35 34
  • 80 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-20 34 35
  • 58 (a)
ManyToMany
ceh-40 34 35
  • 35 (a)
ManyToMany
ceh-60 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8721 34
  • 60 (a)
OneToMany
Species where no ortholog for PBX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PBX2 Gene

ENSEMBL:
Gene Tree for PBX2 (if available)
TreeFam:
Gene Tree for PBX2 (if available)

Paralogs for PBX2 Gene

Paralogs for PBX2 Gene

(4) SIMAP similar genes for PBX2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PBX2 Gene

genes like me logo Genes that share paralogs with PBX2: view

Variants for PBX2 Gene

Sequence variations from dbSNP and Humsavar for PBX2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000 -- 32,186,118(-) AACAT(A/G)CACAT upstream-variant-2KB, utr-variant-3-prime
rs1000286697 -- 32,184,644(+) GGGAA(A/C)AGGAG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1000337149 -- 32,184,909(+) TTCCC(C/T)ACTCT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime
rs1001 -- 32,186,196(-) GGGCC(C/T)CTAAG upstream-variant-2KB, utr-variant-3-prime
rs1001508058 -- 32,184,697(+) CTGGG(A/G)TTTCT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PBX2 Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv10486n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv462877 CNV loss 19166990
nsv602104 CNV loss 21841781
nsv602105 CNV loss 21841781
nsv830629 CNV loss 17160897

Variation tolerance for PBX2 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PBX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PBX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PBX2 Gene

Disorders for PBX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PBX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
duodenal gastrinoma
  • duodenal g-cell gastrin producing tumor
pancreatic gastrinoma
  • pancreatic g-cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search PBX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PBX2

Genetic Association Database (GAD)
PBX2
Human Genome Epidemiology (HuGE) Navigator
PBX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PBX2
genes like me logo Genes that share disorders with PBX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PBX2 Gene

Publications for PBX2 Gene

  1. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PMID: 7835890) Sugaya K … Ikemura T (Genomics 1994) 2 3 4 22 60
  2. Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. (PMID: 12609849) Okada Y … Doi T (Blood 2003) 3 4 22 60
  3. The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. (PMID: 7759099) Aguado B … Campbell RD (Genomics 1995) 3 4 22 60
  4. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. (PMID: 7910944) Lu Q … Kamps MP (Molecular and cellular biology 1994) 3 4 22 60
  5. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. (PMID: 1682799) Monica K … Cleary ML (Molecular and cellular biology 1991) 3 4 22 60

Products for PBX2 Gene

  • Addgene plasmids for PBX2

Sources for PBX2 Gene

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