Aliases for DHH Gene
External Ids for DHH Gene
Previous GeneCards Identifiers for DHH Gene
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010]
GeneCards Summary for DHH Gene
DHH (Desert Hedgehog) is a Protein Coding gene. Diseases associated with DHH include 46,xy gonadal dysgenesis - motor and sensory neuropathy and dhh-related 46,xy dsd and 46,xy cgd. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calcium ion binding and patched binding. An important paralog of this gene is SHH.
UniProtKB/Swiss-Prot for DHH Gene
Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development