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Aliases for TAS2R10 Gene

Aliases for TAS2R10 Gene

  • Taste 2 Receptor Member 10 2 3 5
  • Taste Receptor, Type 2, Member 10 2 3
  • T2R10 3 4
  • TRB2 3 4
  • Taste Receptor, Family B, Member 2 3
  • Taste Receptor Family B Member 2 4
  • Taste Receptor Type 2 Member 10 3

External Ids for TAS2R10 Gene

Previous GeneCards Identifiers for TAS2R10 Gene

  • GC12M010682
  • GC12M011122
  • GC12M010878
  • GC12M010869
  • GC12M010977

Summaries for TAS2R10 Gene

Entrez Gene Summary for TAS2R10 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R10 Gene

TAS2R10 (Taste 2 Receptor Member 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R9.

UniProtKB/Swiss-Prot for TAS2R10 Gene

  • Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Wiki entry for TAS2R10 Gene

Additional gene information for TAS2R10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R10 Gene

Genomics for TAS2R10 Gene

Regulatory Elements for TAS2R10 Gene

Enhancers for TAS2R10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H010384 1.4 FANTOM5 ENCODE dbSUPER 38.8 +441.5 441527 5 TBP FOXA2 ZSCAN4 FEZF1 ZEB1 GTF3C2 FOS ZNF362 YY2 CEBPB TAS2R19 TAS2R31 KLRA1P TAS2R14 TAS2R10 TAS2R15P MAGOHB TAS2R20 TAS2R43 KLRC3
GH12H010391 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +434.2 434182 7 FOXA2 ARID4B FEZF1 ATF7 RUNX3 DEK JUNB TSHZ1 ZNF662 KAT8 KLRA1P KLRK1 TAS2R20 KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R43 MAGOHB
GH12H010715 1.4 ENCODE dbSUPER 12.6 +108.9 108871 8 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS KLRA1P TAS2R20 TAS2R43 TAS2R31 MAGOHB ENSG00000256682 LINC02366 SLC25A39P2 HNRNPABP1 LOC100419929
GH12H010211 1.4 ENCODE dbSUPER 9.9 +615.1 615132 5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KLRA1P LOC642846 DDX12P TAS2R31 LOC255308 TAS2R20 TAS2R19 TAS2R43 TAS2R14 ENSG00000255753
GH12H009829 0.8 FANTOM5 11.5 +998.9 998912 0 ZNF639 RNF2 ZNF621 GFI1B FEZF1 OSR2 ZNF148 PRDM6 BCL11A BCL6B KLRF1 KLRD1 MAGOHB TAS2R10 KLRA1P CLEC12A CLEC12A-AS1 KLRB1 CD69 ENSG00000255882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAS2R10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAS2R10 Gene

Chromosome:
12
Start:
10,815,851 bp from pter
End:
10,828,965 bp from pter
Size:
13,115 bases
Orientation:
Minus strand

Genomic View for TAS2R10 Gene

Genes around TAS2R10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAS2R10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAS2R10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R10 Gene

Proteins for TAS2R10 Gene

  • Protein details for TAS2R10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW0-T2R10_HUMAN
    Recommended name:
    Taste receptor type 2 member 10
    Protein Accession:
    Q9NYW0
    Secondary Accessions:
    • Q3MIM9
    • Q6NTD9

    Protein attributes for TAS2R10 Gene

    Size:
    307 amino acids
    Molecular mass:
    35365 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell.

neXtProt entry for TAS2R10 Gene

Post-translational modifications for TAS2R10 Gene

  • Glycosylation at Asn92 and posLast=158158
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R10 Gene

Domains & Families for TAS2R10 Gene

Gene Families for TAS2R10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAS2R10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW0

UniProtKB/Swiss-Prot:

T2R10_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R10: view

Function for TAS2R10 Gene

Molecular function for TAS2R10 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Gene Ontology (GO) - Molecular Function for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R10: view
genes like me logo Genes that share phenotypes with TAS2R10: view

Animal Model Products

CRISPR Products

miRNA for TAS2R10 Gene

miRTarBase miRNAs that target TAS2R10

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAS2R10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R10 Gene

Localization for TAS2R10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAS2R10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IBA 20022913
genes like me logo Genes that share ontologies with TAS2R10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAS2R10 Gene

Pathways & Interactions for TAS2R10 Gene

genes like me logo Genes that share pathways with TAS2R10: view

Pathways by source for TAS2R10 Gene

Gene Ontology (GO) - Biological Process for TAS2R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050896 response to stimulus IEA --
GO:0050909 sensory perception of taste IEA --
genes like me logo Genes that share ontologies with TAS2R10: view

No data available for SIGNOR curated interactions for TAS2R10 Gene

Drugs & Compounds for TAS2R10 Gene

(20) Drugs for TAS2R10 Gene - From: BitterDB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 183
Benzoin Approved Pharma 0
Chloramphenicol Approved, Vet_approved Pharma 7
chloroquine Approved, Vet_approved Pharma Agonist 152
Dapsone Approved, Investigational Pharma 68

(12) Additional Compounds for TAS2R10 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-alpha Thujone
Absinthin
  • (+)-absinthin
  • Absinthin (van)
  • Absinthin (VAN) (8CI)
  • Absynthin
1362-42-1
Arborescin
Arglabin
Artemorin
genes like me logo Genes that share compounds with TAS2R10: view

Transcripts for TAS2R10 Gene

mRNA/cDNA for TAS2R10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R10 Gene

Taste receptor, type 2, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAS2R10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R10 Gene

No ASD Table

Relevant External Links for TAS2R10 Gene

GeneLoc Exon Structure for
TAS2R10
ECgene alternative splicing isoforms for
TAS2R10

Expression for TAS2R10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAS2R10 Gene

Protein differential expression in normal tissues from HIPED for TAS2R10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAS2R10 Gene



Protein tissue co-expression partners for TAS2R10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAS2R10 Gene:

TAS2R10

SOURCE GeneReport for Unigene cluster for TAS2R10 Gene:

Hs.533756

mRNA Expression by UniProt/SwissProt for TAS2R10 Gene:

Q9NYW0-T2R10_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Evidence on tissue expression from TISSUES for TAS2R10 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TAS2R10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAS2R10 Gene

Orthologs for TAS2R10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R10 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia TAS2R10 33 34
  • 84.16 (n)
cow
(Bos Taurus)
Mammalia TAS2R10 33 34
  • 77.67 (n)
T2R10C 34
  • 63 (a)
OneToMany
BOTA-T2R10B 34
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tas2r114 33
  • 71.77 (n)
mouse
(Mus musculus)
Mammalia Tas2r114 33 16 34
  • 71.23 (n)
Tas2r106 34
  • 57 (a)
OneToMany
Tas2r107 34
  • 56 (a)
OneToMany
Tas2r104 34
  • 55 (a)
OneToMany
Tas2r105 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R22 34
  • 39 (a)
OneToMany
MODO-T2R28 34
  • 38 (a)
OneToMany
T2R26 34
  • 38 (a)
OneToMany
Species where no ortholog for TAS2R10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R10 Gene

ENSEMBL:
Gene Tree for TAS2R10 (if available)
TreeFam:
Gene Tree for TAS2R10 (if available)

Paralogs for TAS2R10 Gene

Pseudogenes.org Pseudogenes for TAS2R10 Gene

genes like me logo Genes that share paralogs with TAS2R10: view

Variants for TAS2R10 Gene

Sequence variations from dbSNP and Humsavar for TAS2R10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000021490 -- 10,827,617(+) GGAAA(A/G)AACTT intron-variant, upstream-variant-2KB
rs1000472531 -- 10,826,874(+) ATACT(C/T)ATGGT intron-variant, upstream-variant-2KB
rs1000479506 -- 10,827,969(+) TCTAC(C/T)AAACA intron-variant, upstream-variant-2KB
rs1001109808 -- 10,827,109(+) ATGAG(G/T)GAGGT intron-variant, upstream-variant-2KB
rs1001773125 -- 10,826,180(+) CAGTT(C/G/T)ACAAG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TAS2R10 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628543 CNV gain 21293372

Variation tolerance for TAS2R10 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAS2R10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R10 Gene

Disorders for TAS2R10 Gene

Relevant External Links for TAS2R10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R10

No disorders were found for TAS2R10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R10 Gene

Publications for TAS2R10 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E … Zuker CS (Cell 2000) 2 3 4 60
  2. The receptors and coding logic for bitter taste. (PMID: 15759003) Mueller KL … Ryba NJ (Nature 2005) 3 4 60
  3. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A … Pääbo S (Molecular biology and evolution 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y … Ryba NJ (Cell 2003) 3 4 60

Products for TAS2R10 Gene

Sources for TAS2R10 Gene

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