Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAS2R13 Gene

Aliases for TAS2R13 Gene

  • Taste Receptor, Type 2, Member 13 2 3
  • T2R13 3 4 6
  • TRB3 3 4 6
  • Taste Receptor Family B Member 3 3 4
  • Taste Receptor, Family B, Member 3 3
  • Taste Receptor Type 2 Member 13 3

External Ids for TAS2R13 Gene

Summaries for TAS2R13 Gene

Entrez Gene Summary for TAS2R13 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R13 Gene

TAS2R13 (Taste Receptor, Type 2, Member 13) is a Protein Coding gene. Diseases associated with TAS2R13 include colorectal cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R13 Gene

  • Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Wiki entry for TAS2R13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R13 Gene

Genomics for TAS2R13 Gene

Genomic Location for TAS2R13 Gene

Start:
10,907,926 bp from pter
End:
10,909,562 bp from pter
Size:
1,637 bases
Orientation:
Minus strand

Genomic View for TAS2R13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R13 Gene

Regulatory Elements for TAS2R13 Gene

Proteins for TAS2R13 Gene

  • Protein details for TAS2R13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV9-T2R13_HUMAN
    Recommended name:
    Taste receptor type 2 member 13
    Protein Accession:
    Q9NYV9
    Secondary Accessions:
    • Q4G0I5
    • Q502V8
    • Q645X2

    Protein attributes for TAS2R13 Gene

    Size:
    303 amino acids
    Molecular mass:
    35118 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli

neXtProt entry for TAS2R13 Gene

Proteomics data for TAS2R13 Gene at MOPED

Post-translational modifications for TAS2R13 Gene

  • Glycosylation at Asn162 and Asn166

Other Protein References for TAS2R13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R13 Gene

Domains for TAS2R13 Gene

Gene Families for TAS2R13 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYV9

UniProtKB/Swiss-Prot:

T2R13_HUMAN
Family:
  • Belongs to the G-protein coupled receptor T2R family.:
    • Q9NYV9
genes like me logo Genes that share domains with TAS2R13: view

Function for TAS2R13 Gene

Molecular function for TAS2R13 Gene

UniProtKB/Swiss-Prot Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Ontology (GO) - Molecular Function for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R13: view

miRNA for TAS2R13 Gene

miRTarBase miRNAs that target TAS2R13

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAS2R13 Gene

Localization for TAS2R13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R13 Gene COMPARTMENTS Subcellular localization image for TAS2R13 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R13: view

Pathways for TAS2R13 Gene

genes like me logo Genes that share pathways with TAS2R13: view

Pathways by source for TAS2R13 Gene

1 KEGG pathway for TAS2R13 Gene

Interacting Proteins for TAS2R13 Gene

Selected Interacting proteins: Q9NYV9-T2R13_HUMAN for TAS2R13 Gene via I2D

Gene Ontology (GO) - Biological Process for TAS2R13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R13: view

Compounds for TAS2R13 Gene

(2) BitterDB Compounds for TAS2R13 Gene

Compound Smiles Cas Number
denatonium benzoate CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2.[O-]C(=O)c3ccccc3 3734-33-6
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
genes like me logo Genes that share compounds with TAS2R13: view

Transcripts for TAS2R13 Gene

mRNA/cDNA for TAS2R13 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R13 Gene

Taste receptor, type 2, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R13 Gene

No ASD Table

Relevant External Links for TAS2R13 Gene

GeneLoc Exon Structure for
TAS2R13
ECgene alternative splicing isoforms for
TAS2R13

Expression for TAS2R13 Gene

mRNA expression in normal human tissues for TAS2R13 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TAS2R13 Gene

SOURCE GeneReport for Unigene cluster for TAS2R13 Gene Hs.679407

mRNA Expression by UniProt/SwissProt for TAS2R13 Gene

Q9NYV9-T2R13_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAS2R13 Gene

Orthologs for TAS2R13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R13 35
  • 98.57 (n)
  • 96.37 (a)
TAS2R13 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia T2R12 36
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CAFA-T2R12 36
  • 32 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tas2r102 36
  • 44 (a)
OneToMany
Tas2r121 35
  • 72.32 (n)
  • 58.98 (a)
Tas2r121 16
Tas2r121 36
  • 57 (a)
OneToMany
Tas2r124 36
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia T2R23 36
  • 34 (a)
ManyToMany
T2R24 36
  • 36 (a)
ManyToMany
T2R25 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r121 35
  • 69.53 (n)
  • 56.44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia t2r8 35
  • 43.43 (n)
  • 31.44 (a)
Species with no ortholog for TAS2R13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R13 Gene

ENSEMBL:
Gene Tree for TAS2R13 (if available)
TreeFam:
Gene Tree for TAS2R13 (if available)

Paralogs for TAS2R13 Gene

genes like me logo Genes that share paralogs with TAS2R13: view

Variants for TAS2R13 Gene

Sequence variations from dbSNP and Humsavar for TAS2R13 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_021853 -
VAR_036432 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for TAS2R13 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
nsv898777 CNV Loss 21882294

Relevant External Links for TAS2R13 Gene

HapMap Linkage Disequilibrium report
TAS2R13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R13 Gene

Disorders for TAS2R13 Gene

(1) MalaCards Diseases for TAS2R13 Gene

Search for TAS2R13 Gene in MalaCards »
genes like me logo Genes that share disorders with TAS2R13: view

No data available for UniProtKB/Swiss-Prot for TAS2R13 Gene

Publications for TAS2R13 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Molecular mechanisms of bitter and sweet taste transduction. (PMID: 11696554) Margolskee R.F. (J. Biol. Chem. 2002) 3 4
  5. Receptors for bitter and sweet taste. (PMID: 12139982) Montmayeur J.-P. … Matsunami H. (Curr. Opin. Neurobiol. 2002) 3 4

Products for TAS2R13 Gene

  • antibodies-online peptides for TAS2R13
  • antibodies-online antibodies for TAS2R13
  • antibodies-online kits for TAS2R13

Sources for TAS2R13 Gene

Back to Top

Content