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Aliases for TAS2R7 Gene

Aliases for TAS2R7 Gene

  • Taste Receptor, Type 2, Member 7 2 3
  • T2R7 3 4 6
  • TRB4 3 4 6
  • Taste Receptor Family B Member 4 3 4
  • Taste Receptor, Family B, Member 4 3
  • Taste Receptor Type 2 Member 7 3

External Ids for TAS2R7 Gene

Previous GeneCards Identifiers for TAS2R7 Gene

  • GC12M010658
  • GC12M011098
  • GC12M010854
  • GC12M010845
  • GC12M010954

Summaries for TAS2R7 Gene

Entrez Gene Summary for TAS2R7 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R7 Gene

TAS2R7 (Taste Receptor, Type 2, Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R7 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Gene Wiki entry for TAS2R7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R7 Gene

Genomics for TAS2R7 Gene

Regulatory Elements for TAS2R7 Gene

Genomic Location for TAS2R7 Gene

Start:
10,801,532 bp from pter
End:
10,802,627 bp from pter
Size:
1,096 bases
Orientation:
Minus strand

Genomic View for TAS2R7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R7 Gene

Proteins for TAS2R7 Gene

  • Protein details for TAS2R7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW3-TA2R7_HUMAN
    Recommended name:
    Taste receptor type 2 member 7
    Protein Accession:
    Q9NYW3
    Secondary Accessions:
    • Q645Y1

    Protein attributes for TAS2R7 Gene

    Size:
    318 amino acids
    Molecular mass:
    36550 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R7 Gene

Proteomics data for TAS2R7 Gene at MOPED

Post-translational modifications for TAS2R7 Gene

  • Glycosylation at Asn167 and Asn175
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R7 Gene

Domains for TAS2R7 Gene

Gene Families for TAS2R7 Gene

HGNC:
  • TASNR :GPCR / Unclassified : Taste receptors
  • TAS2R :Taste receptors / Type 2
IUPHAR :

Protein Domains for TAS2R7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW3

UniProtKB/Swiss-Prot:

TA2R7_HUMAN :
  • Q9NYW3
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R7: view

Function for TAS2R7 Gene

Molecular function for TAS2R7 Gene

UniProtKB/Swiss-Prot Function: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Gene Ontology (GO) - Molecular Function for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
GO:0033038 bitter taste receptor activity IDA 20022913
genes like me logo Genes that share ontologies with TAS2R7: view

Animal Model Products

CRISPR Products

miRNA for TAS2R7 Gene

miRTarBase miRNAs that target TAS2R7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAS2R7 Gene

Localization for TAS2R7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R7 Gene COMPARTMENTS Subcellular localization image for TAS2R7 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IC 20022913
genes like me logo Genes that share ontologies with TAS2R7: view

Pathways for TAS2R7 Gene

genes like me logo Genes that share pathways with TAS2R7: view

Pathways by source for TAS2R7 Gene

1 KEGG pathway for TAS2R7 Gene

Interacting Proteins for TAS2R7 Gene

Gene Ontology (GO) - Biological Process for TAS2R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 20022913
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with TAS2R7: view

Compounds for TAS2R7 Gene

(1) HMDB Compounds for TAS2R7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) BitterDB Compounds for TAS2R7 Gene

Compound Smiles Cas Number
Caffeine CN1C(=O)N(C)c2ncn(C)c2C1=O 58-08-2
Chlorpheniramine CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
cromolyn OC(COc1ccc2OC(=CC(=O)c2c1)C(=O)O)COc3cccc4OC(=CC(=O)c34)C(=O)O
diphenidol OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3
Papaverine COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Quinine COc1ccc2nccc([C@](O)[C@]3CC4CCN3C[C@]4C=C)c2c1
genes like me logo Genes that share compounds with TAS2R7: view

Transcripts for TAS2R7 Gene

mRNA/cDNA for TAS2R7 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R7 Gene

Taste receptor, type 2, member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAS2R7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R7 Gene

No ASD Table

Relevant External Links for TAS2R7 Gene

GeneLoc Exon Structure for
TAS2R7
ECgene alternative splicing isoforms for
TAS2R7

Expression for TAS2R7 Gene

mRNA expression in normal human tissues for TAS2R7 Gene

SOURCE GeneReport for Unigene cluster for TAS2R7 Gene Hs.533754

mRNA Expression by UniProt/SwissProt for TAS2R7 Gene

Q9NYW3-TA2R7_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expressions with TAS2R7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TAS2R7 Gene

Orthologs for TAS2R7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAS2R7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAS2R7 35
  • 99.27 (n)
  • 98.74 (a)
TAS2R7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAS2R7 35
  • 81.5 (n)
  • 73.53 (a)
dog
(Canis familiaris)
Mammalia TAS2R7 35
  • 85.26 (n)
  • 76.92 (a)
TAS2R7 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tas2r130 35
  • 79.59 (n)
  • 68.27 (a)
Tas2r130 16
Tas2r130 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
T2R7A 36
  • 58 (a)
ManyToMany
T2R7B 36
  • 54 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tas2r130 35
  • 78.53 (n)
  • 69.23 (a)
Species with no ortholog for TAS2R7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R7 Gene

ENSEMBL:
Gene Tree for TAS2R7 (if available)
TreeFam:
Gene Tree for TAS2R7 (if available)

Paralogs for TAS2R7 Gene

genes like me logo Genes that share paralogs with TAS2R7: view

Variants for TAS2R7 Gene

Sequence variations from dbSNP and Humsavar for TAS2R7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs619381 - 10,801,659(+) ATAGA(C/T)ATTAC missense, reference
rs1838344 -- 10,804,150(+) GCAAC(C/T)TCCAT upstream-variant-2KB
rs1838345 -- 10,804,195(+) GCCAA(A/G)TAGCT upstream-variant-2KB
rs2418107 -- 10,802,758(+) GTTTG(C/G)CGATC upstream-variant-2KB
rs3759251 - 10,801,784(-) CAGAG(A/T)CGGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAS2R7 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294

Relevant External Links for TAS2R7 Gene

HapMap Linkage Disequilibrium report
TAS2R7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R7 Gene

Disorders for TAS2R7 Gene

No disorders were found for TAS2R7 Gene.

No data available for UniProtKB/Swiss-Prot for TAS2R7 Gene

Publications for TAS2R7 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 3 4
  2. T2Rs function as bitter taste receptors. (PMID: 10761935) Chandrashekar J. … Ryba N.J.P. (Cell 2000) 3 4
  3. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 3
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PMID: 12581520) Zhang Y. … Ryba N.J. (Cell 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TAS2R7 Gene

Sources for TAS2R7 Gene

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