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Aliases for TAS2R9 Gene

Aliases for TAS2R9 Gene

  • Taste Receptor, Type 2, Member 9 2 3
  • Taste Receptor Family B Member 6 3 4
  • T2R9 3 4
  • TRB6 3 4
  • Taste Receptor, Family B, Member 6 3

External Ids for TAS2R9 Gene

Previous GeneCards Identifiers for TAS2R9 Gene

  • GC12M010665
  • GC12M011105
  • GC12M010862
  • GC12M010853
  • GC12M010963
  • GC12M010965
  • GC12M010968
  • GC12M010972

Summaries for TAS2R9 Gene

Entrez Gene Summary for TAS2R9 Gene

  • This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAS2R9 Gene

TAS2R9 (Taste Receptor, Type 2, Member 9) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42.

UniProtKB/Swiss-Prot for TAS2R9 Gene

  • Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).

Gene Wiki entry for TAS2R9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAS2R9 Gene

Genomics for TAS2R9 Gene

Regulatory Elements for TAS2R9 Gene

Genomic Location for TAS2R9 Gene

Chromosome:
12
Start:
10,809,094 bp from pter
End:
10,810,168 bp from pter
Size:
1,075 bases
Orientation:
Minus strand

Genomic View for TAS2R9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAS2R9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAS2R9 Gene

Proteins for TAS2R9 Gene

  • Protein details for TAS2R9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYW1-TA2R9_HUMAN
    Recommended name:
    Taste receptor type 2 member 9
    Protein Accession:
    Q9NYW1
    Secondary Accessions:
    • Q502V7
    • Q50KT0
    • Q50KT1
    • Q645W9

    Protein attributes for TAS2R9 Gene

    Size:
    312 amino acids
    Molecular mass:
    35611 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Several bitter taste receptors are expressed in a single taste receptor cell

neXtProt entry for TAS2R9 Gene

Proteomics data for TAS2R9 Gene at MOPED

Post-translational modifications for TAS2R9 Gene

  • Glycosylation at Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for TAS2R9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAS2R9 Gene

Domains & Families for TAS2R9 Gene

Gene Families for TAS2R9 Gene

Protein Domains for TAS2R9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAS2R9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYW1

UniProtKB/Swiss-Prot:

TA2R9_HUMAN :
  • Belongs to the G-protein coupled receptor T2R family.
Family:
  • Belongs to the G-protein coupled receptor T2R family.
genes like me logo Genes that share domains with TAS2R9: view

Function for TAS2R9 Gene

Molecular function for TAS2R9 Gene

UniProtKB/Swiss-Prot Function:
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).

Gene Ontology (GO) - Molecular Function for TAS2R9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008527 taste receptor activity TAS 10761934
genes like me logo Genes that share ontologies with TAS2R9: view
genes like me logo Genes that share phenotypes with TAS2R9: view

Animal Model Products

CRISPR Products

miRNA for TAS2R9 Gene

miRTarBase miRNAs that target TAS2R9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAS2R9 Gene

Localization for TAS2R9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAS2R9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAS2R9 Gene COMPARTMENTS Subcellular localization image for TAS2R9 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TAS2R9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAS2R9: view

Pathways & Interactions for TAS2R9 Gene

genes like me logo Genes that share pathways with TAS2R9: view

Pathways by source for TAS2R9 Gene

1 KEGG pathway for TAS2R9 Gene

Interacting Proteins for TAS2R9 Gene

Gene Ontology (GO) - Biological Process for TAS2R9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0050909 sensory perception of taste --
GO:0050912 detection of chemical stimulus involved in sensory perception of taste TAS 10761934
genes like me logo Genes that share ontologies with TAS2R9: view

No data available for SIGNOR curated interactions for TAS2R9 Gene

Drugs & Compounds for TAS2R9 Gene

(2) Drugs for TAS2R9 Gene - From: HMDB and BitterDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ofloxacin Approved Pharma Fluoroquinolones,antibiotics 187
Calcium Nutra 0

(2) Additional Compounds for TAS2R9 Gene - From: BitterDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pirenzapin
procainamid
genes like me logo Genes that share compounds with TAS2R9: view

Transcripts for TAS2R9 Gene

mRNA/cDNA for TAS2R9 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAS2R9 Gene

Taste receptor, type 2, member 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAS2R9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAS2R9 Gene

No ASD Table

Relevant External Links for TAS2R9 Gene

GeneLoc Exon Structure for
TAS2R9
ECgene alternative splicing isoforms for
TAS2R9

Expression for TAS2R9 Gene

mRNA expression in normal human tissues for TAS2R9 Gene

SOURCE GeneReport for Unigene cluster for TAS2R9 Gene Hs.272391

mRNA Expression by UniProt/SwissProt for TAS2R9 Gene

Q9NYW1-TA2R9_HUMAN
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells
genes like me logo Genes that share expression patterns with TAS2R9: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAS2R9 Gene

Orthologs for TAS2R9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAS2R9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TAS2R9 35
  • 82.42 (n)
  • 72.58 (a)
chimpanzee
(Pan troglodytes)
Mammalia TAS2R9 35
  • 99.15 (n)
  • 98.4 (a)
TAS2R9 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
ManyToMany
T2R7A 36
  • 46 (a)
ManyToMany
T2R7B 36
  • 47 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tas2r7 35
  • 45.71 (n)
  • 35 (a)
Species with no ortholog for TAS2R9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAS2R9 Gene

ENSEMBL:
Gene Tree for TAS2R9 (if available)
TreeFam:
Gene Tree for TAS2R9 (if available)

Paralogs for TAS2R9 Gene

genes like me logo Genes that share paralogs with TAS2R9: view

Variants for TAS2R9 Gene

Sequence variations from dbSNP and Humsavar for TAS2R9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs151099894 untested, untested 10,810,022(+) CCTAT(A/G)GTCAA reference, synonymous-codon
rs267603298 untested, untested 10,809,297(+) ATTTT(C/T)CCTGA missense, reference
rs267603299 untested, untested 10,809,934(+) GATCA(G/T)GATGA missense, reference
VAR_020204 -
VAR_053345 -

Structural Variations from Database of Genomic Variants (DGV) for TAS2R9 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294

Variation tolerance for TAS2R9 Gene

Residual Variation Intolerance Score: 82.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAS2R9 Gene

HapMap Linkage Disequilibrium report
TAS2R9
Human Gene Mutation Database (HGMD)
TAS2R9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAS2R9 Gene

Disorders for TAS2R9 Gene

Relevant External Links for TAS2R9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAS2R9
genes like me logo Genes that share disorders with TAS2R9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAS2R9 Gene

Publications for TAS2R9 Gene

  1. A novel family of mammalian taste receptors. (PMID: 10761934) Adler E. … Zuker C.S. (Cell 2000) 2 67
  2. A family of candidate taste receptors in human and mouse. (PMID: 10766242) Matsunami H. … Buck L.B. (Nature 2000) 2 67
  3. Bitter taste receptors influence glucose homeostasis. (PMID: 19092995) Dotson C.D. … Munger S.D. (PLoS ONE 2008) 67
  4. Evolution of bitter taste receptors in humans and apes. (PMID: 15496549) Fischer A. … Paeaebo S. (Mol. Biol. Evol. 2005) 67
  5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PMID: 15744053) Go Y. … Takahata N. (Genetics 2005) 67

Products for TAS2R9 Gene

Sources for TAS2R9 Gene

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