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Aliases for PDCL Gene

Aliases for PDCL Gene

  • Phosducin-Like 2 3
  • PhLP 3 4
  • Phosducin-Like Protein 3
  • PHLOP1 4
  • PhLP1 4

External Ids for PDCL Gene

Summaries for PDCL Gene

Entrez Gene Summary for PDCL Gene

  • Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCL Gene

PDCL (Phosducin-Like) is a Protein Coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is PDCL2.

UniProtKB/Swiss-Prot for PDCL Gene

  • Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers

  • Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin

Gene Wiki entry for PDCL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCL Gene

Genomics for PDCL Gene

Genomic Location for PDCL Gene

Start:
122,798,389 bp from pter
End:
122,828,656 bp from pter
Size:
30,268 bases
Orientation:
Minus strand

Genomic View for PDCL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCL Gene

Regulatory Elements for PDCL Gene

Proteins for PDCL Gene

  • Protein details for PDCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13371-PHLP_HUMAN
    Recommended name:
    Phosducin-like protein
    Protein Accession:
    Q13371
    Secondary Accessions:
    • Q4VXB6
    • Q96AF1
    • Q9UEW7
    • Q9UFL0
    • Q9UNX1
    • Q9UNX2

    Protein attributes for PDCL Gene

    Size:
    301 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.

    Alternative splice isoforms for PDCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCL Gene

Proteomics data for PDCL Gene at MOPED

Post-translational modifications for PDCL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys240

Other Protein References for PDCL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCL Gene

Domains for PDCL Gene

UniProtKB/Swiss-Prot:

PHLP_HUMAN
Family:
  • Belongs to the phosducin family.:
    • Q13371
genes like me logo Genes that share domains with PDCL: view

No data available for Gene Families for PDCL Gene

Function for PDCL Gene

Molecular function for PDCL Gene

GENATLAS Biochemistry: phosducin-like protein,a putative heterotrimeric G protein modulator
UniProtKB/Swiss-Prot Function: Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers
UniProtKB/Swiss-Prot Function: Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin

Gene Ontology (GO) - Molecular Function for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 10095058
GO:0005515 protein binding IPI 21516116
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with PDCL: view
genes like me logo Genes that share phenotypes with PDCL: view

miRNA for PDCL Gene

miRTarBase miRNAs that target PDCL

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PDCL Gene

Localization for PDCL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCL Gene COMPARTMENTS Subcellular localization image for PDCL gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PDCL: view

Pathways for PDCL Gene

SuperPathways for PDCL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0007165 signal transduction NAS 10524200
GO:0007601 visual perception IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10095058
GO:0035556 intracellular signal transduction TAS 10095058
genes like me logo Genes that share ontologies with PDCL: view

No data available for Pathways by source for PDCL Gene

Compounds for PDCL Gene

(1) HMDB Compounds for PDCL Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with PDCL: view

Transcripts for PDCL Gene

mRNA/cDNA for PDCL Gene

Unigene Clusters for PDCL Gene

Phosducin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PDCL Gene

GeneLoc Exon Structure for
PDCL
ECgene alternative splicing isoforms for
PDCL

Expression for PDCL Gene

mRNA expression in normal human tissues for PDCL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCL Gene

SOURCE GeneReport for Unigene cluster for PDCL Gene Hs.271749

genes like me logo Genes that share expressions with PDCL: view

Orthologs for PDCL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCL 36
  • 99.45 (n)
  • 98.67 (a)
PDCL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCL 36
  • 87.15 (n)
  • 91.36 (a)
PDCL 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCL 36
  • 90.14 (n)
  • 93.02 (a)
PDCL 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcl 36
  • 89.04 (n)
  • 92.03 (a)
Pdcl 16
Pdcl 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCL 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcl 36
  • 89.15 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves PDCL 36
  • 73.29 (n)
  • 76.77 (a)
PDCL 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCL 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcl 36
  • 66.89 (n)
  • 65.41 (a)
Str.6339 36
zebrafish
(Danio rerio)
Actinopterygii pdcl 36
  • 62.68 (n)
  • 59.47 (a)
pdcl 37
  • 58 (a)
OneToOne
wufc06a08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004468 36
  • 54.37 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7650 36
  • 54.72 (n)
  • 47.92 (a)
CG7650 37
  • 44 (a)
OneToMany
CG7650 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea mau-8 37
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for PDCL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCL Gene

ENSEMBL:
Gene Tree for PDCL (if available)
TreeFam:
Gene Tree for PDCL (if available)

Paralogs for PDCL Gene

Paralogs for PDCL Gene

Selected SIMAP similar genes for PDCL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PDCL: view

Variants for PDCL Gene

Sequence variations from dbSNP and Humsavar for PDCL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1133864 -- 122,819,411(-) AATCT(A/T)TGTAA utr-variant-3-prime
rs1962512 -- 122,823,915(+) caggc(A/T)tgcgc intron-variant
rs3802487 -- 122,828,368(-) TGTCT(C/T)GACCC intron-variant
rs4466466 - 122,820,337(+) GAGCT(C/G)TTCAC missense, reference
rs4579598 -- 122,823,886(+) TGCCT(C/T)AGCTT intron-variant

Relevant External Links for PDCL Gene

HapMap Linkage Disequilibrium report
PDCL

No data available for Structural Variations from Database of Genomic Variants (DGV) for PDCL Gene

Disorders for PDCL Gene

genes like me logo Genes that share disorders with PDCL: view

No data available for UniProtKB/Swiss-Prot for PDCL Gene

Publications for PDCL Gene

  1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. (PMID: 10095058) Thibault C. … Miles M.F. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter. (PMID: 10899582) Lazarov M.E. … Elton T.S. (Biochim. Biophys. Acta 2000) 3 23
  3. Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. (PMID: 15745879) Humrich J. … Lohse M.J. (J. Biol. Chem. 2005) 3 23
  4. Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. (PMID: 15889144) Lukov G.L. … Willardson B.M. (EMBO J. 2005) 3 23
  5. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. (PMID: 19403526) GuzmA!n-HernA!ndez M.L. … VA!zquez-Prado J. (J. Biol. Chem. 2009) 3 23

Products for PDCL Gene

Sources for PDCL Gene

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