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Aliases for PDCL Gene

Aliases for PDCL Gene

  • Phosducin Like 2 3 5
  • PhLP 3 4
  • Phosducin-Like 3
  • PHLOP1 4
  • PhLP1 4

External Ids for PDCL Gene

Previous GeneCards Identifiers for PDCL Gene

  • GC09M116684
  • GC09M117226
  • GC09M119014
  • GC09M120955
  • GC09M122659
  • GC09M124620
  • GC09M125560
  • GC09M095194

Summaries for PDCL Gene

Entrez Gene Summary for PDCL Gene

  • Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCL Gene

PDCL (Phosducin Like) is a Protein Coding gene. Diseases associated with PDCL include allergic hypersensitivity disease and nasal cavity disease. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include protein complex binding and receptor signaling protein activity. An important paralog of this gene is PDCL2.

UniProtKB/Swiss-Prot for PDCL Gene

  • Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

  • Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Gene Wiki entry for PDCL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCL Gene

Genomics for PDCL Gene

Regulatory Elements for PDCL Gene

Promoters for PDCL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDCL on UCSC Golden Path with GeneCards custom track

Genomic Location for PDCL Gene

Chromosome:
9
Start:
122,798,389 bp from pter
End:
122,828,656 bp from pter
Size:
30,268 bases
Orientation:
Minus strand

Genomic View for PDCL Gene

Genes around PDCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCL Gene

Proteins for PDCL Gene

  • Protein details for PDCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13371-PHLP_HUMAN
    Recommended name:
    Phosducin-like protein
    Protein Accession:
    Q13371
    Secondary Accessions:
    • Q4VXB6
    • Q96AF1
    • Q9UEW7
    • Q9UFL0
    • Q9UNX1
    • Q9UNX2

    Protein attributes for PDCL Gene

    Size:
    301 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.

    Alternative splice isoforms for PDCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCL Gene

Proteomics data for PDCL Gene at MOPED

Post-translational modifications for PDCL Gene

  • Ubiquitination at Lys 240
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PDCL Gene

Domains & Families for PDCL Gene

Graphical View of Domain Structure for InterPro Entry

Q13371

UniProtKB/Swiss-Prot:

PHLP_HUMAN :
  • Belongs to the phosducin family.
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDCL: view

No data available for Gene Families for PDCL Gene

Function for PDCL Gene

Molecular function for PDCL Gene

GENATLAS Biochemistry:
phosducin-like protein,a putative heterotrimeric G protein modulator
UniProtKB/Swiss-Prot Function:
Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
UniProtKB/Swiss-Prot Function:
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
genes like me logo Genes that share phenotypes with PDCL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCL Gene

Localization for PDCL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCL Gene COMPARTMENTS Subcellular localization image for PDCL gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDCL Gene

Pathways & Interactions for PDCL Gene

genes like me logo Genes that share pathways with PDCL: view

SIGNOR curated interactions for PDCL Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0007165 signal transduction NAS 10524200
GO:0061084 negative regulation of protein refolding IEA --
genes like me logo Genes that share ontologies with PDCL: view

Drugs & Compounds for PDCL Gene

(1) Drugs for PDCL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PDCL: view

Transcripts for PDCL Gene

Unigene Clusters for PDCL Gene

Phosducin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PDCL Gene

GeneLoc Exon Structure for
PDCL
ECgene alternative splicing isoforms for
PDCL

Expression for PDCL Gene

mRNA expression in normal human tissues for PDCL Gene

Protein differential expression in normal tissues from HIPED for PDCL Gene

This gene is overexpressed in Breast (34.7), Fetal ovary (7.6), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCL Gene



SOURCE GeneReport for Unigene cluster for PDCL Gene Hs.271749

genes like me logo Genes that share expression patterns with PDCL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PDCL Gene

Orthologs for PDCL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCL 35
  • 99.45 (n)
  • 98.67 (a)
PDCL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCL 36
  • 91 (a)
OneToOne
PDCL 35
  • 87.15 (n)
  • 91.36 (a)
dog
(Canis familiaris)
Mammalia PDCL 35
  • 90.14 (n)
  • 93.02 (a)
PDCL 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcl 36
  • 92 (a)
OneToOne
Pdcl 16
Pdcl 35
  • 89.04 (n)
  • 92.03 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PDCL 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcl 35
  • 89.15 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves PDCL 36
  • 76 (a)
OneToOne
PDCL 35
  • 73.29 (n)
  • 76.77 (a)
lizard
(Anolis carolinensis)
Reptilia PDCL 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcl 35
  • 66.89 (n)
  • 65.41 (a)
Str.6339 35
zebrafish
(Danio rerio)
Actinopterygii pdcl 36
  • 58 (a)
OneToOne
pdcl 35
  • 62.68 (n)
  • 59.47 (a)
wufc06a08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004468 35
  • 54.37 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7650 36
  • 44 (a)
OneToMany
CG7650 37
  • 44 (a)
CG7650 35
  • 54.72 (n)
  • 47.92 (a)
worm
(Caenorhabditis elegans)
Secernentea mau-8 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for PDCL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCL Gene

ENSEMBL:
Gene Tree for PDCL (if available)
TreeFam:
Gene Tree for PDCL (if available)

Paralogs for PDCL Gene

Paralogs for PDCL Gene

(1) SIMAP similar genes for PDCL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PDCL: view

Variants for PDCL Gene

Sequence variations from dbSNP and Humsavar for PDCL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4466466 - 122,820,337(-) GAGCT(C/G)TTCAC reference, missense
rs1133864 -- 122,819,411(-) AATCT(A/T)TGTAA utr-variant-3-prime
rs7390359 -- 122,830,596(+) TGCCC(A/G)ACACT upstream-variant-2KB
rs4997232 -- 122,819,894(+) TACAA(C/T)TGTAA utr-variant-3-prime
rs7023344 -- 122,821,959(+) ACATT(C/T)TGAGT intron-variant

Variation tolerance for PDCL Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCL Gene

HapMap Linkage Disequilibrium report
PDCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PDCL Gene

Disorders for PDCL Gene

MalaCards: The human disease database

(4) MalaCards diseases for PDCL Gene - From: DISEASES

Disorder Aliases PubMed IDs
allergic hypersensitivity disease
  • allergic disease
nasal cavity disease
  • disorder of nasal cavity
nose disease
  • disorder of the nose
upper respiratory tract disease
- elite association - COSMIC cancer census association via MalaCards
Search PDCL in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDCL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCL
genes like me logo Genes that share disorders with PDCL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCL Gene

Publications for PDCL Gene

  1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. (PMID: 10095058) Thibault C. … Miles M.F. (Biochim. Biophys. Acta 1999) 2 3 4 23 67
  2. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. (PMID: 19403526) GuzmA!n-HernA!ndez M.L. … VA!zquez-Prado J. (J. Biol. Chem. 2009) 3 23
  3. Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex. (PMID: 16717095) Lukov G.L. … Willardson B.M. (J. Biol. Chem. 2006) 3 23
  4. Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. (PMID: 15889144) Lukov G.L. … Willardson B.M. (EMBO J. 2005) 3 23
  5. Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. (PMID: 15745879) Humrich J. … Lohse M.J. (J. Biol. Chem. 2005) 3 23

Products for PDCL Gene

Sources for PDCL Gene

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