External Ids for PDCL Gene
Previous GeneCards Identifiers for PDCL Gene
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCL Gene
PDCL (Phosducin-Like) is a Protein Coding gene. Diseases associated with PDCL include nasal cavity disease and nose disease. GO annotations related to this gene include protein complex binding and receptor signaling protein activity. An important paralog of this gene is PDCL2.
UniProtKB/Swiss-Prot for PDCL Gene
Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin