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Aliases for PDCL Gene

Aliases for PDCL Gene

  • Phosducin Like 2 3 5
  • PhLP 3 4
  • Phosducin-Like Protein 3
  • PHLOP1 4
  • PhLP1 4

External Ids for PDCL Gene

Previous GeneCards Identifiers for PDCL Gene

  • GC09M116684
  • GC09M117226
  • GC09M119014
  • GC09M120955
  • GC09M122659
  • GC09M124620
  • GC09M125560
  • GC09M095194

Summaries for PDCL Gene

Entrez Gene Summary for PDCL Gene

  • Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDCL Gene

PDCL (Phosducin Like) is a Protein Coding gene. Diseases associated with PDCL include Timothy Grass Allergy and Tomato Allergy. Among its related pathways are Chaperonin-mediated protein folding and Metabolism of proteins. GO annotations related to this gene include protein complex binding and signal transducer activity, downstream of receptor. An important paralog of this gene is PDC.

UniProtKB/Swiss-Prot for PDCL Gene

  • Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

  • Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Gene Wiki entry for PDCL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCL Gene

Genomics for PDCL Gene

Regulatory Elements for PDCL Gene

Enhancers for PDCL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122826 1.4 ENCODE dbSUPER 0.7 +1.0 1005 3.2 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 MORN5 STRBP PDCL GC09M122816
GH09G122819 1.4 Ensembl ENCODE dbSUPER 0.4 +7.8 7761 3.6 HDAC1 PKNOX1 FOXA2 TBL1XR1 TCF12 ZNF766 GATA2 FOS RELB CREM OR1K1 OR5C1 SNORD90 GC09M122816 PDCL
GH09G122835 0.7 Ensembl ENCODE 0.4 -6.9 -6865 0.7 CTCF SMARCA4 RAD21 ZBTB6 SNORD90 OR1K1 KRT18P67 PDCL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDCL on UCSC Golden Path with GeneCards custom track

Promoters for PDCL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241076 256 1600 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for PDCL Gene

Chromosome:
9
Start:
122,798,389 bp from pter
End:
122,828,656 bp from pter
Size:
30,268 bases
Orientation:
Minus strand

Genomic View for PDCL Gene

Genes around PDCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCL Gene

Proteins for PDCL Gene

  • Protein details for PDCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13371-PHLP_HUMAN
    Recommended name:
    Phosducin-like protein
    Protein Accession:
    Q13371
    Secondary Accessions:
    • Q4VXB6
    • Q96AF1
    • Q9UEW7
    • Q9UFL0
    • Q9UNX1
    • Q9UNX2

    Protein attributes for PDCL Gene

    Size:
    301 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    • Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.

    Alternative splice isoforms for PDCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCL Gene

Post-translational modifications for PDCL Gene

  • Ubiquitination at posLast=240240
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCL Gene

No data available for DME Specific Peptides for PDCL Gene

Domains & Families for PDCL Gene

Graphical View of Domain Structure for InterPro Entry

Q13371

UniProtKB/Swiss-Prot:

PHLP_HUMAN :
  • Belongs to the phosducin family.
Family:
  • Belongs to the phosducin family.
genes like me logo Genes that share domains with PDCL: view

No data available for Gene Families for PDCL Gene

Function for PDCL Gene

Molecular function for PDCL Gene

GENATLAS Biochemistry:
phosducin-like protein,a putative heterotrimeric G protein modulator
UniProtKB/Swiss-Prot Function:
Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
UniProtKB/Swiss-Prot Function:
Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Gene Ontology (GO) - Molecular Function for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor TAS 10095058
GO:0005515 protein binding IPI 21516116
GO:0008479 contributes_to queuine tRNA-ribosyltransferase activity IBA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with PDCL: view
genes like me logo Genes that share phenotypes with PDCL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PDCL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCL Gene

Localization for PDCL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCL gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDCL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCL Gene

Pathways & Interactions for PDCL Gene

genes like me logo Genes that share pathways with PDCL: view

SIGNOR curated interactions for PDCL Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PDCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007165 signal transduction NAS 10524200
GO:0007601 visual perception IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10095058
GO:0008616 queuosine biosynthetic process IBA --
genes like me logo Genes that share ontologies with PDCL: view

Drugs & Compounds for PDCL Gene

(1) Drugs for PDCL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PDCL: view

Transcripts for PDCL Gene

Unigene Clusters for PDCL Gene

Phosducin-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PDCL

Alternative Splicing Database (ASD) splice patterns (SP) for PDCL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for PDCL Gene

GeneLoc Exon Structure for
PDCL
ECgene alternative splicing isoforms for
PDCL

Expression for PDCL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCL Gene

Protein differential expression in normal tissues from HIPED for PDCL Gene

This gene is overexpressed in Breast (34.7), Fetal ovary (7.6), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCL Gene



NURSA nuclear receptor signaling pathways regulating expression of PDCL Gene:

PDCL

SOURCE GeneReport for Unigene cluster for PDCL Gene:

Hs.271749

Evidence on tissue expression from TISSUES for PDCL Gene

  • Nervous system(4.5)
  • Skin(2.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PDCL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCL Gene

Orthologs for PDCL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCL 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia PDCL 34 35
  • 90.14 (n)
rat
(Rattus norvegicus)
Mammalia Pdcl 34
  • 89.15 (n)
mouse
(Mus musculus)
Mammalia Pdcl 34 16 35
  • 89.04 (n)
cow
(Bos Taurus)
Mammalia PDCL 34 35
  • 87.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDCL 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCL 34 35
  • 73.29 (n)
lizard
(Anolis carolinensis)
Reptilia PDCL 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcl 34
  • 66.89 (n)
Str.6339 34
zebrafish
(Danio rerio)
Actinopterygii pdcl 34 35
  • 62.68 (n)
wufc06a08 34
fruit fly
(Drosophila melanogaster)
Insecta CG7650 36 34 35
  • 54.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004468 34
  • 54.37 (n)
worm
(Caenorhabditis elegans)
Secernentea mau-8 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP2 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for PDCL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCL Gene

ENSEMBL:
Gene Tree for PDCL (if available)
TreeFam:
Gene Tree for PDCL (if available)

Paralogs for PDCL Gene

Paralogs for PDCL Gene

(1) SIMAP similar genes for PDCL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PDCL: view

Variants for PDCL Gene

Sequence variations from dbSNP and Humsavar for PDCL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000103836 -- 122,818,327(+) ATTAT(A/C)TATCC utr-variant-3-prime
rs1000193961 -- 122,830,456(+) TTTGC(C/T)GAGGC upstream-variant-2KB
rs1000244984 -- 122,818,564(+) AGCTT(A/T)CTTAG utr-variant-3-prime
rs1000296201 -- 122,824,435(+) AAACT(A/G)AGGCT intron-variant
rs1000369487 -- 122,827,949(+) ACCTC(G/T)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCL Gene

Variant ID Type Subtype PubMed ID
nsv615270 CNV gain 21841781

Variation tolerance for PDCL Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCL Gene

Disorders for PDCL Gene

MalaCards: The human disease database

(7) MalaCards diseases for PDCL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
timothy grass allergy
tomato allergy
  • solanum lycopersicum fruit allergy
peach allergy
  • prunus persica fruit allergy
nasal cavity disease
  • disorder of nasal cavity
upper respiratory tract disease
- elite association - COSMIC cancer census association via MalaCards
Search PDCL in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDCL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCL
genes like me logo Genes that share disorders with PDCL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCL Gene

Publications for PDCL Gene

  1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. (PMID: 10095058) Thibault C. … Miles M.F. (Biochim. Biophys. Acta 1999) 2 3 4 22 64
  2. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. (PMID: 23888055) Gao X. … Sokolov M. (J. Biol. Chem. 2013) 3 4 64
  3. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PMID: 19376773) Howlett A.C. … Willardson B.M. (J. Biol. Chem. 2009) 3 4 64
  4. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. (PMID: 19403526) GuzmA!n-HernA!ndez M.L. … VA!zquez-Prado J. (J. Biol. Chem. 2009) 3 22 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for PDCL Gene

Sources for PDCL Gene

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