Aliases for PAX7 Gene
External Ids for PAX7 Gene
Previous GeneCards Identifiers for PAX7 Gene
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for PAX7 Gene
PAX7 (Paired Box 7) is a Protein Coding gene. Diseases associated with PAX7 include Rhabdomyosarcoma 2, Alveolar and Embryonal Rhabdomyosarcoma. Among its related pathways are miRs in Muscle Cell Differentiation and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor activity, RNA polymerase II core promoter sequence-specific. An important paralog of this gene is PAX3.
UniProtKB/Swiss-Prot for PAX7 Gene
Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.