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Aliases for IRX4 Gene

Aliases for IRX4 Gene

  • Iroquois Homeobox 4 2 3 5
  • Iroquois Homeobox Protein 4 2 3 4
  • Homeodomain Protein IRXA3 3 4
  • IRXA3 3 4

External Ids for IRX4 Gene

Previous GeneCards Identifiers for IRX4 Gene

  • GC05M002018
  • GC05M001910

Summaries for IRX4 Gene

GeneCards Summary for IRX4 Gene

IRX4 (Iroquois Homeobox 4) is a Protein Coding gene. Diseases associated with IRX4 include Familial Atrial Fibrillation. Among its related pathways are Cardiac Progenitor Differentiation and Heart Development. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX2.

UniProtKB/Swiss-Prot for IRX4 Gene

  • Likely to be an important mediator of ventricular differentiation during cardiac development.

Gene Wiki entry for IRX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX4 Gene

Genomics for IRX4 Gene

Regulatory Elements for IRX4 Gene

Enhancers for IRX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRX4 Gene

1,877,413 bp from pter
1,887,236 bp from pter
9,824 bases
Minus strand

Genomic View for IRX4 Gene

Genes around IRX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX4 Gene

Proteins for IRX4 Gene

  • Protein details for IRX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iroquois-class homeodomain protein IRX-4
    Protein Accession:
    Secondary Accessions:
    • B2RMW5
    • D3DTC5
    • H1AFL0
    • H1AFL1
    • Q2NL64
    • Q9UHR2

    Protein attributes for IRX4 Gene

    519 amino acids
    Molecular mass:
    54445 Da
    Quaternary structure:
    • Interacts with the vitamin D receptor VDR but doesnt affect its transactivation activity.

    Alternative splice isoforms for IRX4 Gene


neXtProt entry for IRX4 Gene

Proteomics data for IRX4 Gene at MOPED

Post-translational modifications for IRX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IRX4 Gene

Domains & Families for IRX4 Gene

Gene Families for IRX4 Gene

Suggested Antigen Peptide Sequences for IRX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX4: view

Function for IRX4 Gene

Molecular function for IRX4 Gene

UniProtKB/Swiss-Prot Function:
Likely to be an important mediator of ventricular differentiation during cardiac development.
genes like me logo Genes that share phenotypes with IRX4: view

Animal Models for IRX4 Gene

MGI Knock Outs for IRX4:

Animal Model Products

miRNA for IRX4 Gene

miRTarBase miRNAs that target IRX4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRX4 Gene

Localization for IRX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX4 Gene

Subcellular locations from

Jensen Localization Image for IRX4 Gene COMPARTMENTS Subcellular localization image for IRX4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for IRX4 Gene

Pathways & Interactions for IRX4 Gene

genes like me logo Genes that share pathways with IRX4: view

Pathways by source for IRX4 Gene

2 BioSystems pathways for IRX4 Gene

Gene Ontology (GO) - Biological Process for IRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048561 establishment of organ orientation IEA --
genes like me logo Genes that share ontologies with IRX4: view

No data available for SIGNOR curated interactions for IRX4 Gene

Drugs & Compounds for IRX4 Gene

No Compound Related Data Available

Transcripts for IRX4 Gene

Unigene Clusters for IRX4 Gene

Iroquois homeobox 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX4 Gene

No ASD Table

Relevant External Links for IRX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRX4 Gene

mRNA expression in normal human tissues for IRX4 Gene

mRNA differential expression in normal tissues according to GTEx for IRX4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x10.5), Esophagus - Mucosa (x8.3), Skin - Sun Exposed (Lower leg) (x8.0), Heart - Left Ventricle (x6.3), Vagina (x5.1), Minor Salivary Gland (x4.9), and Prostate (x4.6).

Protein differential expression in normal tissues from HIPED for IRX4 Gene

This gene is overexpressed in Heart (45.5) and Peripheral blood mononuclear cells (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRX4 Gene

SOURCE GeneReport for Unigene cluster for IRX4 Gene Hs.196927

mRNA Expression by UniProt/SwissProt for IRX4 Gene

Tissue specificity: Predominantly expressed in cardiac ventricles.
genes like me logo Genes that share expression patterns with IRX4: view

Protein tissue co-expression partners for IRX4 Gene

- Elite partner

Primer Products

Orthologs for IRX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRX4 35
  • 87.66 (n)
  • 87.6 (a)
IRX4 36
  • 87 (a)
(Mus musculus)
Mammalia Irx4 35
  • 80.56 (n)
  • 82.19 (a)
Irx4 16
Irx4 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Irx4 35
  • 79.71 (n)
  • 80.82 (a)
(Canis familiaris)
Mammalia IRX4 36
  • 82 (a)
(Monodelphis domestica)
Mammalia IRX4 36
  • 70 (a)
(Pan troglodytes)
Mammalia IRX4 36
  • 78 (a)
(Gallus gallus)
Aves IRX4 35
  • 75.78 (n)
  • 73.31 (a)
IRX4 36
  • 71 (a)
(Anolis carolinensis)
Reptilia IRX4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irx4 35
  • 64.8 (n)
  • 66.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12086 35
(Danio rerio)
Actinopterygii Dr.25775 35
irx4a 35
  • 70.1 (n)
  • 67.92 (a)
irx4a 36
  • 66 (a)
irx4b 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta ara 37
  • 47 (a)
caup 37
  • 49 (a)
mirr 37
  • 48 (a)
ara 36
  • 22 (a)
caup 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
-- 36
  • 21 (a)
Species with no ortholog for IRX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX4 Gene

Gene Tree for IRX4 (if available)
Gene Tree for IRX4 (if available)

Paralogs for IRX4 Gene

Paralogs for IRX4 Gene

(3) SIMAP similar genes for IRX4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IRX4: view

Variants for IRX4 Gene

Sequence variations from dbSNP and Humsavar for IRX4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2232376 - 1,880,777(-) CAGCC(A/G)CTGCC reference, missense
rs901496 -- 1,885,310(-) TACTG(C/G)CTGCC intron-variant
rs901497 -- 1,885,287(-) GGCTG(C/T)TTCTC intron-variant
rs185463 -- 1,881,102(-) CACAT(A/C)CCCGC intron-variant
rs192323 -- 1,885,300(-) CCTGG(A/G)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX4 Gene

Variant ID Type Subtype PubMed ID
dgv5924n71 CNV Loss 21882294
nsv881557 CNV Loss 21882294
dgv5925n71 CNV Loss 21882294
nsv822961 CNV Loss 20364138
nsv822962 CNV Gain 20364138
esv25789 CNV Loss 19812545
dgv5926n71 CNV Loss 21882294

Variation tolerance for IRX4 Gene

Gene Damage Index Score: 5.59; 72.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRX4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX4 Gene

Disorders for IRX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRX4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search IRX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRX4 Gene

Publications for IRX4 Gene

  1. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. (PMID: 10625552) Bruneau B.G. … Seidman C.E. (Dev. Biol. 2000) 2 3 4 23 67
  2. Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. (PMID: 11382777) Wang G.F. … Stockdale F.E. (J. Biol. Chem. 2001) 3 23
  3. Variants at IRX4 as prostate cancer expression quantitative trait loci. (PMID: 24022300) Xu X. … Klein R.J. (Eur. J. Hum. Genet. 2014) 3
  4. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. (PMID: 22323358) Nguyen H.H. … Nakagawa H. (Hum. Mol. Genet. 2012) 3
  5. Two novel mutations of the IRX4 gene in patients with congenital heart disease. (PMID: 21544582) Cheng Z. … Ma X. (Hum. Genet. 2011) 3

Products for IRX4 Gene

Sources for IRX4 Gene