Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK4 Gene

Aliases for KCNK4 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 4 2 3
  • TRAAK 3 4 6
  • TWIK-Related Arachidonic Acid-Stimulated Potassium Channel Protein 3 4
  • Potassium Channel, Subfamily K, Member 4 2 3
  • Two Pore Potassium Channel KT4.1 3 4
  • Two Pore K(+) Channel KT4.1 3 4
  • Potassium Channel Subfamily K Member 4 3
  • Two Pore K+ Channel KT4.1 3
  • K2P4.1 Potassium Channel 3
  • K2p4.1 3
  • TRAAK1 3

External Ids for KCNK4 Gene

Summaries for KCNK4 Gene

Entrez Gene Summary for KCNK4 Gene

  • Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK4 Gene

KCNK4 (Potassium Channel, Two Pore Domain Subfamily K, Member 4) is a Protein Coding gene. Diseases associated with KCNK4 include dentin sensitivity. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK4 Gene

  • Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Gene Wiki entry for KCNK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK4 Gene

Genomics for KCNK4 Gene

Genomic Location for KCNK4 Gene

Start:
64,291,302 bp from pter
End:
64,300,031 bp from pter
Size:
8,730 bases
Orientation:
Plus strand

Genomic View for KCNK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK4 Gene

Regulatory Elements for KCNK4 Gene

Proteins for KCNK4 Gene

  • Protein details for KCNK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG8-KCNK4_HUMAN
    Recommended name:
    Potassium channel subfamily K member 4
    Protein Accession:
    Q9NYG8
    Secondary Accessions:
    • B5TJL1
    • Q96T94

    Protein attributes for KCNK4 Gene

    Size:
    393 amino acids
    Molecular mass:
    42704 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for KCNK4 Gene

    Alternative splice isoforms for KCNK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK4 Gene

Proteomics data for KCNK4 Gene at MOPED

Post-translational modifications for KCNK4 Gene

Other Protein References for KCNK4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK4 Gene

Domains for KCNK4 Gene

Gene Families for KCNK4 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

UniProtKB/Swiss-Prot:

KCNK4_HUMAN
Domain:
  • Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.:
    • Q9NYG8
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.:
    • Q9NYG8
genes like me logo Genes that share domains with KCNK4: view

Function for KCNK4 Gene

Molecular function for KCNK4 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activated by arachidonic acid.
UniProtKB/Swiss-Prot Function: Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Gene Ontology (GO) - Molecular Function for KCNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA 22282805
GO:0022841 potassium ion leak channel activity IBA --
GO:0097604 temperature-gated cation channel activity ISS --
genes like me logo Genes that share ontologies with KCNK4: view

Phenotypes for KCNK4 Gene

genes like me logo Genes that share phenotypes with KCNK4: view

Animal Models for KCNK4 Gene

MGI Knock Outs for KCNK4:

miRNA for KCNK4 Gene

miRTarBase miRNAs that target KCNK4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNK4 Gene

Localization for KCNK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK4 Gene COMPARTMENTS Subcellular localization image for KCNK4 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0034705 potassium channel complex IDA 22282805
genes like me logo Genes that share ontologies with KCNK4: view

Pathways for KCNK4 Gene

genes like me logo Genes that share pathways with KCNK4: view

Interacting Proteins for KCNK4 Gene

Gene Ontology (GO) - Biological Process for KCNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 10767409
GO:0007268 synaptic transmission TAS --
GO:0019233 sensory perception of pain ISS --
GO:0030322 stabilization of membrane potential IBA --
genes like me logo Genes that share ontologies with KCNK4: view

Compounds for KCNK4 Gene

(5) Tocris Compounds for KCNK4 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
Tetraethylammonium chloride Non-selective K+ channel blocker [56-34-8]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [33978-72-2]

(2) IUPHAR Ligand for KCNK4 Gene

Ligand Type Action Affinity Pubmed IDs
arachidonic acid Activator Potentiation
riluzole Activator None

(2) Novoseek inferred chemical compound relationships for KCNK4 Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 66.8 7
potassium 29.8 1
genes like me logo Genes that share compounds with KCNK4: view

Transcripts for KCNK4 Gene

Unigene Clusters for KCNK4 Gene

Potassium channel, subfamily K, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - -
SP7: - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10:
SP11: - - - -

ExUns: 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KCNK4 Gene

GeneLoc Exon Structure for
KCNK4
ECgene alternative splicing isoforms for
KCNK4

Expression for KCNK4 Gene

mRNA expression in normal human tissues for KCNK4 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.4), Brain - Amygdala (6.1), Brain - Hippocampus (6.1), Brain - Cortex (6.0), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Caudate (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.8), and Brain - Putamen (basal ganglia) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK4 Gene

SOURCE GeneReport for Unigene cluster for KCNK4 Gene Hs.647233

genes like me logo Genes that share expressions with KCNK4: view

Orthologs for KCNK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK4 36
  • 99.58 (n)
  • 100 (a)
KCNK4 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK4 36
  • 88.35 (n)
  • 91.33 (a)
KCNK4 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK4 36
  • 88.83 (n)
  • 89.2 (a)
KCNK4 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk4 36
  • 81.51 (n)
  • 82.44 (a)
Kcnk4 16
Kcnk4 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK4 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk4 36
  • 80.7 (n)
  • 81.89 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk4 36
  • 60.14 (n)
  • 59.05 (a)
zebrafish
(Danio rerio)
Actinopterygii BX465841.1 37
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
ManyToMany
CSA.6929 37
  • 32 (a)
ManyToMany
Species with no ortholog for KCNK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK4 Gene

ENSEMBL:
Gene Tree for KCNK4 (if available)
TreeFam:
Gene Tree for KCNK4 (if available)

Paralogs for KCNK4 Gene

Selected SIMAP similar genes for KCNK4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNK4: view

Variants for KCNK4 Gene

Sequence variations from dbSNP and Humsavar for KCNK4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs676931 -- 64,296,248(-) TTATA(C/T)GCACA intron-variant
rs2232407 -- 64,290,853(+) AGTAG(C/T)GGGTG upstream-variant-2KB
rs2232408 -- 64,290,926(+) CAGAG(A/G)GTCTT upstream-variant-2KB
rs2232409 -- 64,290,973(+) GGCGG(A/G)GCAAG upstream-variant-2KB
rs2232410 -- 64,291,350(+) TGCGG(A/G)CCCTT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNK4 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897684 CNV Loss 21882294
nsv897685 CNV Loss 21882294
dgv1168n71 CNV Loss 21882294
nsv357 CNV Insertion 18451855

Relevant External Links for KCNK4 Gene

HapMap Linkage Disequilibrium report
KCNK4

Disorders for KCNK4 Gene

(1) MalaCards Diseases for KCNK4 Gene

Search for KCNK4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KCNK4 Gene

(1) Novoseek inferred disease relationships for KCNK4 Gene

Disease -log(P) Hits PubMed IDs
ischemia 10.3 1

Relevant External Links for KCNK4

Genetic Association Database (GAD)
KCNK4
Human Genome Epidemiology (HuGE) Navigator
KCNK4
genes like me logo Genes that share disorders with KCNK4: view

No data available for UniProtKB/Swiss-Prot for KCNK4 Gene

Publications for KCNK4 Gene

  1. Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two- pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. (PMID: 12191490) Ozaita A. … Vega-Saenz de Miera E. (Brain Res. Mol. Brain Res. 2002) 3 4 23
  2. Cloning and expression of human TRAAK, a polyunsaturated fatty acids- activated and mechano-sensitive K(+) channel. (PMID: 10767409) Lesage F. … Lazdunski M. (FEBS Lett. 2000) 2 3 4
  3. Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. (PMID: 11042359) Chapman C.G. … Gloger I.S. (Brain Res. Mol. Brain Res. 2000) 3 4
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  5. The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. (PMID: 11172753) Meadows H.J. … Randall A.D. (Brain Res. 2001) 3 23

Products for KCNK4 Gene

Sources for KCNK4 Gene

Back to Top

Content