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Aliases for KCNK4 Gene

Aliases for KCNK4 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 4 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 4 2 3 5
  • TWIK-Related Arachidonic Acid-Stimulated Potassium Channel Protein 3 4
  • Potassium Channel, Subfamily K, Member 4 2 3
  • Two Pore Potassium Channel KT4.1 3 4
  • Two Pore K(+) Channel KT4.1 3 4
  • TRAAK 3 4
  • Two Pore K+ Channel KT4.1 3
  • K2P4.1 Potassium Channel 3
  • K2p4.1 3
  • TRAAK1 3

External Ids for KCNK4 Gene

Previous GeneCards Identifiers for KCNK4 Gene

  • GC11P066574
  • GC11P065740
  • GC11P064309
  • GC11P063834
  • GC11P063815
  • GC11P064058
  • GC11P060386

Summaries for KCNK4 Gene

Entrez Gene Summary for KCNK4 Gene

  • This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

GeneCards Summary for KCNK4 Gene

KCNK4 (Potassium Two Pore Domain Channel Subfamily K Member 4) is a Protein Coding gene. Diseases associated with KCNK4 include dentin sensitivity. Among its related pathways are Transmission across Chemical Synapses and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK4 Gene

  • Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Tocris Summary for KCNK4 Gene

Gene Wiki entry for KCNK4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK4 Gene

Genomics for KCNK4 Gene

Regulatory Elements for KCNK4 Gene

Genomic Location for KCNK4 Gene

Chromosome:
11
Start:
64,291,302 bp from pter
End:
64,300,031 bp from pter
Size:
8,730 bases
Orientation:
Plus strand

Genomic View for KCNK4 Gene

Genes around KCNK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK4 Gene

Proteins for KCNK4 Gene

  • Protein details for KCNK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG8-KCNK4_HUMAN
    Recommended name:
    Potassium channel subfamily K member 4
    Protein Accession:
    Q9NYG8
    Secondary Accessions:
    • B5TJL1
    • Q96T94

    Protein attributes for KCNK4 Gene

    Size:
    393 amino acids
    Molecular mass:
    42704 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for KCNK4 Gene

    Alternative splice isoforms for KCNK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK4 Gene

Proteomics data for KCNK4 Gene at MOPED

Post-translational modifications for KCNK4 Gene

Other Protein References for KCNK4 Gene

Antibody Products

No data available for DME Specific Peptides for KCNK4 Gene

Domains & Families for KCNK4 Gene

Gene Families for KCNK4 Gene

Suggested Antigen Peptide Sequences for KCNK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYG8

UniProtKB/Swiss-Prot:

KCNK4_HUMAN :
  • Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
Domain:
  • Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK4: view

Function for KCNK4 Gene

Molecular function for KCNK4 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by arachidonic acid.
UniProtKB/Swiss-Prot Function:
Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Gene Ontology (GO) - Molecular Function for KCNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IEA,IDA 22282805
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK4: view
genes like me logo Genes that share phenotypes with KCNK4: view

Animal Models for KCNK4 Gene

MGI Knock Outs for KCNK4:

Animal Model Products

miRNA for KCNK4 Gene

miRTarBase miRNAs that target KCNK4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK4 Gene

Localization for KCNK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK4 Gene COMPARTMENTS Subcellular localization image for KCNK4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for KCNK4 Gene

Pathways & Interactions for KCNK4 Gene

genes like me logo Genes that share pathways with KCNK4: view

Interacting Proteins for KCNK4 Gene

Gene Ontology (GO) - Biological Process for KCNK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 10767409
GO:0007613 memory IEA --
GO:0030322 stabilization of membrane potential IBA --
GO:0050976 detection of mechanical stimulus involved in sensory perception of touch IEA,ISS --
GO:0071260 cellular response to mechanical stimulus IDA 22282805
genes like me logo Genes that share ontologies with KCNK4: view

No data available for SIGNOR curated interactions for KCNK4 Gene

Drugs & Compounds for KCNK4 Gene

(3) Drugs for KCNK4 Gene - From: Novoseek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riluzole Approved, Investigational Pharma Activator, blocker Sodium channel protein inhibitor 59
arachidonic acid Experimental Nutra Activator 27

(5) Additional Compounds for KCNK4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
PK-THPP
1332454-07-5

(5) Tocris Compounds for KCNK4 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
genes like me logo Genes that share compounds with KCNK4: view

Transcripts for KCNK4 Gene

Unigene Clusters for KCNK4 Gene

Potassium channel, subfamily K, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - -
SP7: - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10:
SP11: - - - -

ExUns: 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KCNK4 Gene

GeneLoc Exon Structure for
KCNK4
ECgene alternative splicing isoforms for
KCNK4

Expression for KCNK4 Gene

mRNA expression in normal human tissues for KCNK4 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Amygdala (x6.1), Brain - Hippocampus (x6.1), Brain - Cortex (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Caudate (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Putamen (basal ganglia) (x4.7).

Protein differential expression in normal tissues from HIPED for KCNK4 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK4 Gene



SOURCE GeneReport for Unigene cluster for KCNK4 Gene Hs.647233

genes like me logo Genes that share expression patterns with KCNK4: view

Protein tissue co-expression partners for KCNK4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNK4 Gene

Orthologs for KCNK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK4 35
  • 88.35 (n)
  • 91.33 (a)
KCNK4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK4 35
  • 88.83 (n)
  • 89.2 (a)
KCNK4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk4 35
  • 81.51 (n)
  • 82.44 (a)
Kcnk4 16
Kcnk4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK4 35
  • 99.58 (n)
  • 100 (a)
KCNK4 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk4 35
  • 80.7 (n)
  • 81.89 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK4 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk4 35
  • 60.14 (n)
  • 59.05 (a)
zebrafish
(Danio rerio)
Actinopterygii BX465841.1 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
CSA.6929 36
  • 32 (a)
ManyToMany
Species with no ortholog for KCNK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK4 Gene

ENSEMBL:
Gene Tree for KCNK4 (if available)
TreeFam:
Gene Tree for KCNK4 (if available)

Paralogs for KCNK4 Gene

(6) SIMAP similar genes for KCNK4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNK4: view

Variants for KCNK4 Gene

Sequence variations from dbSNP and Humsavar for KCNK4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_020206 -
rs676931 -- 64,296,248(-) TTATA(C/T)GCACA intron-variant
rs2232407 -- 64,290,853(+) AGTAG(C/T)GGGTG upstream-variant-2KB
rs2232408 -- 64,290,926(+) CAGAG(A/G)GTCTT upstream-variant-2KB
rs2232409 -- 64,290,973(+) GGCGG(A/G)GCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK4 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897684 CNV Loss 21882294
nsv897685 CNV Loss 21882294
dgv1168n71 CNV Loss 21882294
nsv357 CNV Insertion 18451855

Variation tolerance for KCNK4 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK4 Gene

HapMap Linkage Disequilibrium report
KCNK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK4 Gene

Disorders for KCNK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search KCNK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNK4

Genetic Association Database (GAD)
KCNK4
Human Genome Epidemiology (HuGE) Navigator
KCNK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK4
genes like me logo Genes that share disorders with KCNK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK4 Gene

Publications for KCNK4 Gene

  1. Cloning and expression of human TRAAK, a polyunsaturated fatty acids- activated and mechano-sensitive K(+) channel. (PMID: 10767409) Lesage F. … Lazdunski M. (FEBS Lett. 2000) 2 3 4 67
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  3. Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two- pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. (PMID: 12191490) Ozaita A. … Vega-Saenz de Miera E. (Brain Res. Mol. Brain Res. 2002) 3 23
  4. The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. (PMID: 11172753) Meadows H.J. … Randall A.D. (Brain Res. 2001) 3 23
  5. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. (PMID: 24550493) Brohawn S.G. … MacKinnon R. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for KCNK4 Gene

Sources for KCNK4 Gene

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