Aliases for PAPPA Gene
- Pregnancy-Associated Plasma Protein A, Pappalysin 1 2 3
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease 2 3
- Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease 3 4
- Differentially Placenta 1 Expressed Protein 2 3
- Aspecific BCL2 ARE-Binding Protein 2 2 3
- IGF-Dependent IGFBP-4 Protease 3 4
- IGFBP-4ase 3 4
- PAPP-A 3 4
- Pregnancy-Associated Plasma Protein A 4
External Ids for PAPPA Gene
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
GeneCards Summary for PAPPA Gene
PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1) is a Protein Coding gene. Diseases associated with PAPPA include tricuspid valve insufficiency and edwards syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include metallopeptidase activity and endopeptidase activity. An important paralog of this gene is PAPPA2.
UniProtKB/Swiss-Prot for PAPPA Gene
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.