Aliases for NEUROG3 Gene
External Ids for NEUROG3 Gene
Previous GeneCards Identifiers for NEUROG3 Gene
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
GeneCards Summary for NEUROG3 Gene
NEUROG3 (Neurogenin 3) is a Protein Coding gene. Diseases associated with NEUROG3 include diarrhea 4, malabsorptive, congenital and congenital malabsorptive diarrhea due to paucity of enteroendocrine cells. Among its related pathways are Developmental Biology and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NEUROG1.
UniProtKB/Swiss-Prot for NEUROG3 Gene
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).