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Aliases for NEUROG3 Gene

Aliases for NEUROG3 Gene

  • Neurogenin 3 2 3
  • Class A Basic Helix-Loop-Helix Protein 7 3 4
  • Protein Atonal Homolog 5 3 4
  • BHLHa7 3 4
  • Atoh5 3 4
  • NGN-3 3 4
  • Ngn3 3 4
  • Math4B 3

External Ids for NEUROG3 Gene

Previous GeneCards Identifiers for NEUROG3 Gene

  • GC10M070143
  • GC10M070418
  • GC10M071224
  • GC10M070676
  • GC10M071001
  • GC10M071331
  • GC10M065321

Summaries for NEUROG3 Gene

Entrez Gene Summary for NEUROG3 Gene

  • The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

GeneCards Summary for NEUROG3 Gene

NEUROG3 (Neurogenin 3) is a Protein Coding gene. Diseases associated with NEUROG3 include congenital malabsorptive diarrhea due to paucity of enteroendocrine cells and diarrhea 4, malabsorptive, congenital. Among its related pathways are Developmental Biology and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROG3 Gene

  • Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

Gene Wiki entry for NEUROG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG3 Gene

Genomics for NEUROG3 Gene

Regulatory Elements for NEUROG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEUROG3 Gene

Chromosome:
10
Start:
69,571,698 bp from pter
End:
69,573,454 bp from pter
Size:
1,757 bases
Orientation:
Minus strand

Genomic View for NEUROG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NEUROG3 Gene

Proteins for NEUROG3 Gene

  • Protein details for NEUROG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4Z2-NGN3_HUMAN
    Recommended name:
    Neurogenin-3
    Protein Accession:
    Q9Y4Z2
    Secondary Accessions:
    • Q5VVI0
    • Q6DJX6
    • Q9BY24

    Protein attributes for NEUROG3 Gene

    Size:
    214 amino acids
    Molecular mass:
    23077 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8.

neXtProt entry for NEUROG3 Gene

Proteomics data for NEUROG3 Gene at MOPED

Post-translational modifications for NEUROG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NEUROG3 (Neurogenin-3)
  • Cloud-Clone Corp. Antibodies for NEUROG3

No data available for DME Specific Peptides for NEUROG3 Gene

Domains & Families for NEUROG3 Gene

Gene Families for NEUROG3 Gene

Protein Domains for NEUROG3 Gene

Suggested Antigen Peptide Sequences for NEUROG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4Z2

UniProtKB/Swiss-Prot:

NGN3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROG3: view

Function for NEUROG3 Gene

Molecular function for NEUROG3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14576336
GO:0001047 core promoter binding ISS --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 14576336
GO:0003690 double-stranded DNA binding --
genes like me logo Genes that share ontologies with NEUROG3: view
genes like me logo Genes that share phenotypes with NEUROG3: view

Animal Models for NEUROG3 Gene

MGI Knock Outs for NEUROG3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEUROG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NEUROG3 Gene

Localization for NEUROG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROG3 Gene COMPARTMENTS Subcellular localization image for NEUROG3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 20807725
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NEUROG3: view

Pathways & Interactions for NEUROG3 Gene

genes like me logo Genes that share pathways with NEUROG3: view

Gene Ontology (GO) - Biological Process for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14576336
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organismal development --
GO:0007399 nervous system development TAS 9000438
genes like me logo Genes that share ontologies with NEUROG3: view

No data available for SIGNOR curated interactions for NEUROG3 Gene

Drugs & Compounds for NEUROG3 Gene

(1) Additional Compounds for NEUROG3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glucose
genes like me logo Genes that share compounds with NEUROG3: view

Transcripts for NEUROG3 Gene

mRNA/cDNA for NEUROG3 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG3 Gene

Neurogenin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEUROG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG3 Gene

No ASD Table

Relevant External Links for NEUROG3 Gene

GeneLoc Exon Structure for
NEUROG3
ECgene alternative splicing isoforms for
NEUROG3

Expression for NEUROG3 Gene

mRNA expression in normal human tissues for NEUROG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROG3 Gene

This gene is overexpressed in Brain - Hippocampus (x20.4), Small Intestine - Terminal Ileum (x8.4), and Colon - Transverse (x6.8).

SOURCE GeneReport for Unigene cluster for NEUROG3 Gene Hs.532682

genes like me logo Genes that share expression patterns with NEUROG3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NEUROG3 Gene

Orthologs for NEUROG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEUROG3 35
  • 85.36 (n)
  • 82.71 (a)
NEUROG3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG3 35
  • 85.2 (n)
  • 85.05 (a)
NEUROG3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurog3 35
  • 78.72 (n)
  • 76.53 (a)
Neurog3 16
Neurog3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEUROG3 35
  • 99.17 (n)
  • 99.01 (a)
NEUROG3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog3 35
  • 79.97 (n)
  • 77.93 (a)
oppossum
(Monodelphis domestica)
Mammalia NEUROG3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurog3 35
  • 58.42 (n)
  • 55.91 (a)
zebrafish
(Danio rerio)
Actinopterygii neurog3 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tap 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NEUROG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEUROG3 Gene

ENSEMBL:
Gene Tree for NEUROG3 (if available)
TreeFam:
Gene Tree for NEUROG3 (if available)

Paralogs for NEUROG3 Gene

(4) SIMAP similar genes for NEUROG3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROG3: view

Variants for NEUROG3 Gene

Sequence variations from dbSNP and Humsavar for NEUROG3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_029003 Diarrhea 4, malabsorptive, congenital (DIAR4)
VAR_029004 Diarrhea 4, malabsorptive, congenital (DIAR4)
VAR_055316 -

Structural Variations from Database of Genomic Variants (DGV) for NEUROG3 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407

Variation tolerance for NEUROG3 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.95; 87.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROG3 Gene

HapMap Linkage Disequilibrium report
NEUROG3
Human Gene Mutation Database (HGMD)
NEUROG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEUROG3 Gene

Disorders for NEUROG3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NEUROG3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
congenital malabsorptive diarrhea due to paucity of enteroendocrine cells
  • diarrhea 4, malabsorptive, congenital
diarrhea 4, malabsorptive, congenital
  • enteric anendocrinosis
diarrhea
  • dysentery
non-functioning pancreatic endocrine tumor
  • non functioning pancreatic endocrine tumor
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association

UniProtKB/Swiss-Prot

NGN3_HUMAN
  • Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370]: A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. {ECO:0000269 PubMed:16855267}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NEUROG3

Genetic Association Database (GAD)
NEUROG3
Human Genome Epidemiology (HuGE) Navigator
NEUROG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROG3
genes like me logo Genes that share disorders with NEUROG3: view

No data available for Genatlas for NEUROG3 Gene

Publications for NEUROG3 Gene

  1. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. (PMID: 19882138) Vetere A. … Sharma A. (Diabetologia 2010) 23 67
  2. Using neurogenin to reprogram chick RPE to produce photoreceptor-like neurons. (PMID: 19628733) Li X. … Wang S.Z. (Invest. Ophthalmol. Vis. Sci. 2010) 23 67
  3. Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation. (PMID: 20215568) Zhang T. … Lan M.S. (Endocrinology 2010) 23 67
  4. 5'-AZA induces Ngn3 expression and endocrine differentiation in the PANC-1 human ductal cell line. (PMID: 19913512) Lefebvre B. … Kerr-Conte J. (Biochem. Biophys. Res. Commun. 2010) 23 67
  5. Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas. (PMID: 20033803) Al-Masri M. … Wang R. (Diabetologia 2010) 23 67

Products for NEUROG3 Gene

Sources for NEUROG3 Gene

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