Aliases for PAK3 Gene
External Ids for PAK3 Gene
Previous HGNC Symbols for PAK3 Gene
Previous GeneCards Identifiers for PAK3 Gene
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Apr 2016]
GeneCards Summary for PAK3 Gene
PAK3 (P21 Protein (Cdc42/Rac)-Activated Kinase 3) is a Protein Coding gene. Diseases associated with PAK3 include Mental Retardation, X-Linked 30/47 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Axon guidance and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PAK1.
UniProtKB/Swiss-Prot for PAK3 Gene
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.