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Aliases for SERPINB2 Gene

Aliases for SERPINB2 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • PLANH2 3 4 6
  • PAI2 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2 2 3
  • Placental Plasminogen Activator Inhibitor 3 4
  • Monocyte Arg-Serpin 3 4
  • Urokinase Inhibitor 3 4
  • Serpin B2 3 4
  • PAI-2 3 4
  • Plasminogen Activator Inhibitor, Type II (Arginine-Serpin) 3
  • Plasminogen Activator Inhibitor 2 3
  • HsT1201 3
  • PAI 3

External Ids for SERPINB2 Gene

Previous Symbols for SERPINB2 Gene

  • PLANH2
  • PAI2

Summaries for SERPINB2 Gene

GeneCards Summary for SERPINB2 Gene

SERPINB2 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 2) is a Protein Coding gene. Diseases associated with SERPINB2 include joint disorders and gingivitis. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB2 Gene

  • Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1

Gene Wiki entry for SERPINB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB2 Gene

Genomics for SERPINB2 Gene

Genomic Location for SERPINB2 Gene

Start:
63,871,692 bp from pter
End:
63,903,890 bp from pter
Size:
32,199 bases
Orientation:
Plus strand

Genomic View for SERPINB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB2 Gene

Regulatory Elements for SERPINB2 Gene

Proteins for SERPINB2 Gene

  • Protein details for SERPINB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05120-PAI2_HUMAN
    Recommended name:
    Plasminogen activator inhibitor 2
    Protein Accession:
    P05120
    Secondary Accessions:
    • Q96E96

    Protein attributes for SERPINB2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46596 Da
    Quaternary structure:
    • Interacts with PSMB1.

    Three dimensional structures from OCA and Proteopedia for SERPINB2 Gene

neXtProt entry for SERPINB2 Gene

Proteomics data for SERPINB2 Gene at MOPED

Post-translational modifications for SERPINB2 Gene

Other Protein References for SERPINB2 Gene

No data available for DME Specific Peptides for SERPINB2 Gene

Domains for SERPINB2 Gene

Gene Families for SERPINB2 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05120

UniProtKB/Swiss-Prot:

PAI2_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • P05120
genes like me logo Genes that share domains with SERPINB2: view

Function for SERPINB2 Gene

Molecular function for SERPINB2 Gene

UniProtKB/Swiss-Prot Function: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1

Gene Ontology (GO) - Molecular Function for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
genes like me logo Genes that share ontologies with SERPINB2: view
genes like me logo Genes that share phenotypes with SERPINB2: view

Animal Models for SERPINB2 Gene

MGI Knock Outs for SERPINB2:

miRNA for SERPINB2 Gene

miRTarBase miRNAs that target SERPINB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SERPINB2 Gene

Localization for SERPINB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB2 Gene

Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB2 Gene COMPARTMENTS Subcellular localization image for SERPINB2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

Pathways for SERPINB2 Gene

genes like me logo Genes that share pathways with SERPINB2: view

Pathways by source for SERPINB2 Gene

1 R&D Systems pathway for SERPINB2 Gene
1 GeneGo (Thomson Reuters) pathway for SERPINB2 Gene
2 BioSystems pathways for SERPINB2 Gene
2 Reactome pathways for SERPINB2 Gene
1 KEGG pathway for SERPINB2 Gene

Gene Ontology (GO) - Biological Process for SERPINB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
GO:0042060 wound healing --
GO:0042730 fibrinolysis TAS --
genes like me logo Genes that share ontologies with SERPINB2: view

Compounds for SERPINB2 Gene

(2) Drugbank Compounds for SERPINB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tenecteplase
  • t- PA
191588-94-0 target
Urokinase
  • U-plasminogen activator
9039-53-6 target

(44) Novoseek inferred chemical compound relationships for SERPINB2 Gene

Compound -log(P) Hits PubMed IDs
oxamflatin 69 3
scca1 62.7 2
serine 61.3 32
linomide 44.7 3
tcdd 44.6 23
genes like me logo Genes that share compounds with SERPINB2: view

Transcripts for SERPINB2 Gene

Unigene Clusters for SERPINB2 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for SERPINB2 Gene

GeneLoc Exon Structure for
SERPINB2
ECgene alternative splicing isoforms for
SERPINB2

Expression for SERPINB2 Gene

mRNA expression in normal human tissues for SERPINB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB2 Gene

This gene is overexpressed in Minor Salivary Gland (17.2) and Esophagus - Mucosa (17.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB2 Gene

SOURCE GeneReport for Unigene cluster for SERPINB2 Gene Hs.594481

genes like me logo Genes that share expressions with SERPINB2: view

No data available for mRNA Expression by UniProt/SwissProt for SERPINB2 Gene

Orthologs for SERPINB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB2 35
  • 98.71 (n)
  • 98.07 (a)
SERPINB2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SERPINB2 35
  • 82.25 (n)
  • 77.11 (a)
SERPINB2 36
  • 79 (a)
OneToMany
SERPINB2 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SERPINB2 35
  • 83.57 (n)
  • 78.26 (a)
SERPINB2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpinb2 35
  • 80.32 (n)
  • 75.9 (a)
Serpinb2 16
Serpinb2 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SERPINB2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERPINB2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpinb2 35
  • 77.99 (n)
  • 72.77 (a)
chicken
(Gallus gallus)
Aves SERPINB2 35
  • 58.48 (n)
  • 51.11 (a)
SERPINB2 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERPINB2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii serpinb1l1 36
  • 47 (a)
ManyToMany
serpinb1l3 36
  • 43 (a)
ManyToMany
serpinb1l4 36
  • 45 (a)
ManyToMany
si:ch73-303g23.4 36
  • 43 (a)
ManyToMany
zgc:173729 36
  • 43 (a)
ManyToMany
Species with no ortholog for SERPINB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINB2 Gene

ENSEMBL:
Gene Tree for SERPINB2 (if available)
TreeFam:
Gene Tree for SERPINB2 (if available)

Paralogs for SERPINB2 Gene

genes like me logo Genes that share paralogs with SERPINB2: view

Variants for SERPINB2 Gene

Sequence variations from dbSNP and Humsavar for SERPINB2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs6093 -- 63,891,644(+) TGGGC(C/T)GAGTA intron-variant
rs6094 -- 63,891,648(+) CCGAG(G/T)AGTTC intron-variant
rs6095 -- 63,891,422(+) TTCCT(C/G)TCTTT intron-variant
rs6096 -- 63,895,374(+) GATGC(A/C/G)ATTTT synonymous-codon, reference
rs6097 -- 63,903,317(+) GCGTG(C/T)TGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SERPINB2 Gene

Variant ID Type Subtype PubMed ID
esv21739 CNV Gain 19812545
nsv909693 CNV Gain 21882294
nsv525889 CNV Loss 19592680
dgv1034e1 CNV Complex 17122850
nsv833673 CNV Gain 17160897
essv7909 CNV CNV 17122850

Relevant External Links for SERPINB2 Gene

HapMap Linkage Disequilibrium report
SERPINB2
Human Gene Mutation Database (HGMD)
SERPINB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB2 Gene

Disorders for SERPINB2 Gene

(70) Novoseek inferred disease relationships for SERPINB2 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 53 15
metastasis 51.7 37
fibrosarcoma 46.2 6
tumors 45.1 62
stage ovarian cancer 44.1 1

Relevant External Links for SERPINB2

Genetic Association Database (GAD)
SERPINB2
Human Genome Epidemiology (HuGE) Navigator
SERPINB2
genes like me logo Genes that share disorders with SERPINB2: view

No data available for UniProtKB/Swiss-Prot for SERPINB2 Gene

Publications for SERPINB2 Gene

  1. Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin. (PMID: 2303256) Samia J.A. … Webb A.C. (Genomics 1990) 3 4 23
  2. Genetic polymorphisms and spontaneous preterm birth. (PMID: 17267840) Gibson C.S. … Nelson K.B. (Obstet Gynecol 2007) 3 23 48
  3. Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis. (PMID: 19117638) Di Bernardo M.C. … Houlston R.S. (Lung Cancer 2009) 3 23 48
  4. Up-regulation of plasminogen activator inhibitor-2 is associated with high-risk HPV and grade of cervical lesion at baseline but does not predict outcomes of high-risk HPV infections or incident CIN. (PMID: 19926580) SyrjAonen S. … SyrjAonen K. (Am. J. Clin. Pathol. 2009) 3 23
  5. cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. (PMID: 3029122) Ye R.D. … Sadler J.E. (J. Biol. Chem. 1987) 3 4

Products for SERPINB2 Gene

Sources for SERPINB2 Gene

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