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Aliases for FURIN Gene

Aliases for FURIN Gene

  • Furin (Paired Basic Amino Acid Cleaving Enzyme) 2 3
  • PCSK3 3 4 6
  • PACE 3 4 6
  • FUR 3 4 6
  • Paired Basic Amino Acid Residue-Cleaving Enzyme 3 4
  • EC 4 63
  • Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein) 2
  • Proprotein Convertase Subtilisin/Kexin Type 3 3
  • Furin, Membrane Associated Receptor Protein 3
  • Dibasic Processing Enzyme 3
  • Dibasic-Processing Enzyme 4
  • FES Upstream Region 3
  • EC 3.4.21 63
  • Furin 3
  • SPC1 3

External Ids for FURIN Gene

Previous HGNC Symbols for FURIN Gene

  • PCSK3
  • FUR
  • PACE

Previous GeneCards Identifiers for FURIN Gene

  • GC15P084851
  • GC15P088999
  • GC15P089141
  • GC15P089212
  • GC15P091411
  • GC15P067523

Summaries for FURIN Gene

Entrez Gene Summary for FURIN Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for FURIN Gene

FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)) is a Protein Coding gene. Diseases associated with FURIN include dementia, familial british and plague. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is PCSK1.

UniProtKB/Swiss-Prot for FURIN Gene

  • Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Gene Wiki entry for FURIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FURIN Gene

Genomics for FURIN Gene

Regulatory Elements for FURIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FURIN Gene

90,868,592 bp from pter
90,883,458 bp from pter
14,867 bases
Plus strand

Genomic View for FURIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FURIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FURIN Gene

Proteins for FURIN Gene

  • Protein details for FURIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q14336
    • Q6LBS3
    • Q9UCZ5

    Protein attributes for FURIN Gene

    794 amino acids
    Molecular mass:
    86678 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters.

    Three dimensional structures from OCA and Proteopedia for FURIN Gene

neXtProt entry for FURIN Gene

Proteomics data for FURIN Gene at MOPED

Post-translational modifications for FURIN Gene

  • Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.
  • The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
  • Ubiquitination at Lys748
  • Glycosylation at Asn387, Asn440, and Asn553
  • Modification sites at PhosphoSitePlus

Other Protein References for FURIN Gene

Antibody Products

Domains for FURIN Gene

Gene Families for FURIN Gene

Suggested Antigen Peptide Sequences for FURIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface
  • Belongs to the peptidase S8 family. Furin subfamily.
  • Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface
  • Contains 1 peptidase S8 domain.
  • Belongs to the peptidase S8 family. Furin subfamily.
genes like me logo Genes that share domains with FURIN: view

Function for FURIN Gene

Molecular function for FURIN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg- -Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors
UniProtKB/Swiss-Prot EnzymeRegulation:
Could be inhibited by the not secondly cleaved propeptide
UniProtKB/Swiss-Prot Function:
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Enzyme Numbers (IUBMB) for FURIN Gene

Gene Ontology (GO) - Molecular Function for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 14744861
GO:0004175 endopeptidase activity IDA 17010968
GO:0004252 serine-type endopeptidase activity IDA 10567353
GO:0004867 serine-type endopeptidase inhibitor activity IDA 10567353
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FURIN: view
genes like me logo Genes that share phenotypes with FURIN: view

Animal Models for FURIN Gene

MGI Knock Outs for FURIN:

Animal Model Products

miRNA for FURIN Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FURIN

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for FURIN Gene

Localization for FURIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FURIN Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.

Subcellular locations from

Jensen Localization Image for FURIN Gene COMPARTMENTS Subcellular localization image for FURIN gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
chloroplast 1
cytoskeleton 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 NOT extracellular space IDA 10567353
GO:0005796 Golgi lumen TAS --
GO:0005802 trans-Golgi network IDA 14744861
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FURIN: view

Pathways for FURIN Gene

genes like me logo Genes that share pathways with FURIN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IDA 16912035
GO:0006508 proteolysis TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0008283 cell proliferation IMP 15899807
genes like me logo Genes that share ontologies with FURIN: view

Drugs for FURIN Gene

(2) Drugbank Compounds for FURIN Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Decanoic Acid
  • Capric acid
334-48-5 2969 Target experimental
53179-13-8 40632 Target investigational

(2) HMDB Compounds for FURIN Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Capric acid
  • 1-Nonanecarboxylate

(47) Novoseek inferred chemical compound relationships for FURIN Gene

Compound -log(P) Hits PubMed IDs
dfurin2 84.5 2
arg-arg 69.6 1
exotoxin-a 67.4 8
serine 67.3 47
prosomatostatin 59.1 3
genes like me logo Genes that share compounds with FURIN: view

Transcripts for FURIN Gene

Unigene Clusters for FURIN Gene

Furin (paired basic amino acid cleaving enzyme):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FURIN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FURIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15

Relevant External Links for FURIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FURIN Gene

mRNA expression in normal human tissues for FURIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FURIN Gene

This gene is overexpressed in Liver (7.4) and Whole Blood (5.2).

Protein differential expression in normal tissues for FURIN Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (37.9), Salivary gland (12.3), Skin (8.6), and Placenta (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FURIN Gene

SOURCE GeneReport for Unigene cluster for FURIN Gene Hs.513153

mRNA Expression by UniProt/SwissProt for FURIN Gene

Tissue specificity: Seems to be expressed ubiquitously
genes like me logo Genes that share expressions with FURIN: view

Primer Products

In Situ Assay Products

No data available for Expression partners for FURIN Gene

Orthologs for FURIN Gene

This gene was present in the common ancestor of animals.

Orthologs for FURIN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FURIN 35
  • 89.76 (n)
  • 93.83 (a)
  • 95 (a)
(Canis familiaris)
Mammalia FURIN 35
  • 90.79 (n)
  • 95.83 (a)
  • 96 (a)
(Mus musculus)
Mammalia Furin 35
  • 88.52 (n)
  • 93.95 (a)
Furin 16
Furin 36
  • 94 (a)
(Pan troglodytes)
Mammalia FURIN 35
  • 99.5 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Furin 35
  • 89.28 (n)
  • 93.82 (a)
(Monodelphis domestica)
Mammalia FURIN 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia FURIN 36
  • 58 (a)
(Gallus gallus)
Aves FURIN 35
  • 77.58 (n)
  • 80.82 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia FURIN 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia furin 35
  • 67.31 (n)
  • 70.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397747 35
(Danio rerio)
Actinopterygii furina 35
  • 66.19 (n)
  • 68.1 (a)
furina 36
  • 64 (a)
furinb 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001330 35
  • 60.01 (n)
  • 60.8 (a)
(Caenorhabditis elegans)
Secernentea kpc-1 35
  • 56.61 (n)
  • 61.06 (a)
Species with no ortholog for FURIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FURIN Gene

Gene Tree for FURIN (if available)
Gene Tree for FURIN (if available)

Paralogs for FURIN Gene

Paralogs for FURIN Gene

(6) SIMAP similar genes for FURIN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FURIN: view

Variants for FURIN Gene

Sequence variations from dbSNP and Humsavar for FURIN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs6224 -- 90,880,313(+) CCGCC(G/T)CCTCT intron-variant
rs6225 -- 90,880,109(+) AAACG(G/T)CTCGA reference, synonymous-codon
rs6226 -- 90,881,344(+) CCAGG(C/G/T)TTCGC synonymous-codon, reference
rs6227 -- 90,882,002(+) GACTG(C/T)TTCCC utr-variant-3-prime
rs6228 -- 90,882,265(+) TCCAG(A/G)CAGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FURIN Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
dgv2436n71 CNV Loss 21882294
esv22296 CNV Loss 19812545

Relevant External Links for FURIN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FURIN Gene

Disorders for FURIN Gene

(5) University of Copenhagen DISEASES for FURIN Gene

(38) Novoseek inferred disease relationships for FURIN Gene

Disease -log(P) Hits PubMed IDs
dementia, familial british 81.4 2
anthrax 71 20
amyloidosis familial 70.8 3
fowl plague 45.8 2
colon carcinoma 44.9 10

Relevant External Links for FURIN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FURIN: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for FURIN Gene

Publications for FURIN Gene

  1. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. (PMID: 7690548) Takahashi S. … Nakayama K. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. (PMID: 2251280) Wise R.J. … Kaufman R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  3. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PMID: 11331585) Crump C.M. … Thomas G. (EMBO J. 2001) 3 4 23
  4. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. (PMID: 8846780) Jones B.G. … Thomas G. (EMBO J. 1995) 3 4 23
  5. Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. (PMID: 1629222) Leduc R. … Thomas G. (J. Biol. Chem. 1992) 3 4 23

Products for FURIN Gene

Sources for FURIN Gene

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