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Aliases for PEBP1 Gene

Aliases for PEBP1 Gene

  • Phosphatidylethanolamine Binding Protein 1 2 3
  • RKIP 3 4 6
  • PBP 3 4 6
  • Hippocampal Cholinergic Neurostimulating Peptide 2 3
  • Raf Kinase Inhibitory Protein 2 3
  • Raf Kinase Inhibitor Protein 3 4
  • Prostatic Binding Protein 2 3
  • Prostatic-Binding Protein 3 4
  • Neuropolypeptide H3 3 4
  • HCNPpp 3 4
  • PEBP-1 3 4
  • PEBP 3 4
  • Phosphatidylethanolamine-Binding Protein 1 3
  • Epididymis Secretory Protein Li 34 3
  • Epididymis Luminal Protein 210 3
  • HEL-S-34 3
  • HEL-210 3
  • HCNP 3

External Ids for PEBP1 Gene

Previous HGNC Symbols for PEBP1 Gene

  • PBP

Previous GeneCards Identifiers for PEBP1 Gene

  • GC12P117058
  • GC12P118573
  • GC12P115583

Summaries for PEBP1 Gene

GeneCards Summary for PEBP1 Gene

PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and ErbB1 downstream signaling. GO annotations related to this gene include protein kinase binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PEBP4.

UniProtKB/Swiss-Prot for PEBP1 Gene

  • Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.

  • HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Wiki entry for PEBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEBP1 Gene

Genomics for PEBP1 Gene

Regulatory Elements for PEBP1 Gene

Genomic Location for PEBP1 Gene

Start:
118,135,858 bp from pter
End:
118,145,585 bp from pter
Size:
9,728 bases
Orientation:
Plus strand

Genomic View for PEBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PEBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEBP1 Gene

Proteins for PEBP1 Gene

  • Protein details for PEBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30086-PEBP1_HUMAN
    Recommended name:
    Phosphatidylethanolamine-binding protein 1
    Protein Accession:
    P30086
    Secondary Accessions:
    • B2R4S1

    Protein attributes for PEBP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21057 Da
    Quaternary structure:
    • Has a tendency to form dimers by disulfide cross-linking (By similarity). Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues Ser-338, Ser-339, Tyr-340 and Tyr-341. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for PEBP1 Gene

neXtProt entry for PEBP1 Gene

Proteomics data for PEBP1 Gene at MOPED

Post-translational modifications for PEBP1 Gene

  • Ubiquitination at Lys7, Lys47, Lys113, and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for PEBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PEBP1 Gene

Domains for PEBP1 Gene

Protein Domains for PEBP1 Gene

Suggested Antigen Peptide Sequences for PEBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P30086

UniProtKB/Swiss-Prot:

PEBP1_HUMAN :
  • P30086
Family:
  • Belongs to the phosphatidylethanolamine-binding protein family.
genes like me logo Genes that share domains with PEBP1: view

No data available for Gene Families for PEBP1 Gene

Function for PEBP1 Gene

Molecular function for PEBP1 Gene

UniProtKB/Swiss-Prot Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
UniProtKB/Swiss-Prot Function: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).

Gene Ontology (GO) - Molecular Function for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 17097642
GO:0005524 ATP binding IEA --
GO:0008429 phosphatidylethanolamine binding TAS 7637590
GO:0019899 enzyme binding IPI 21831839
genes like me logo Genes that share ontologies with PEBP1: view

Phenotypes for PEBP1 Gene

MGI mutant phenotypes for PEBP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PEBP1: view

miRNA for PEBP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PEBP1 Gene

Localization for PEBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEBP1 Gene COMPARTMENTS Subcellular localization image for PEBP1 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PEBP1: view

Pathways for PEBP1 Gene

genes like me logo Genes that share pathways with PEBP1: view

Pathways by source for PEBP1 Gene

1 Qiagen pathway for PEBP1 Gene
1 Cell Signaling Technology pathway for PEBP1 Gene

Gene Ontology (GO) - Biological Process for PEBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PEBP1: view

Compounds for PEBP1 Gene

(2150) HMDB Compounds for PEBP1 Gene

Compound Synonyms Cas Number PubMed IDs
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available
PC(14:0/16:1(9Z))
  • 1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine
Not Available

(12) Novoseek inferred chemical compound relationships for PEBP1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylethanolamine 69 21
glyceraldehyde 3-phosphate 58 6
manganese superoxide 40.1 1
flutamide 31.9 1
malate 18.2 2
genes like me logo Genes that share compounds with PEBP1: view

Transcripts for PEBP1 Gene

mRNA/cDNA for PEBP1 Gene

Unigene Clusters for PEBP1 Gene

Phosphatidylethanolamine binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEBP1 Gene

No ASD Table

Relevant External Links for PEBP1 Gene

GeneLoc Exon Structure for
PEBP1
ECgene alternative splicing isoforms for
PEBP1

Expression for PEBP1 Gene

mRNA expression in normal human tissues for PEBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEBP1 Gene

This gene is overexpressed in Adrenal Gland (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEBP1 Gene

SOURCE GeneReport for Unigene cluster for PEBP1 Gene Hs.433863

genes like me logo Genes that share expressions with PEBP1: view

No data available for mRNA Expression by UniProt/SwissProt for PEBP1 Gene

Orthologs for PEBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEBP1 35
  • 99.47 (n)
  • 100 (a)
PEBP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEBP1 35
  • 89.84 (n)
  • 93.58 (a)
PEBP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PEBP1 35
  • 89.13 (n)
  • 91.98 (a)
PEBP1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pbp2 36
  • 84 (a)
OneToMany
Pebp1 35
  • 86.1 (n)
  • 86.1 (a)
Pebp1 16
Pebp1 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PEBP1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pebp1 35
  • 83.42 (n)
  • 83.42 (a)
chicken
(Gallus gallus)
Aves PEBP1 35
  • 75.76 (n)
  • 80.21 (a)
PEBP1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PEBP1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pebp1 35
  • 71.53 (n)
  • 76.76 (a)
zebrafish
(Danio rerio)
Actinopterygii pebp1 35
  • 68.98 (n)
  • 71.66 (a)
pebp1 36
  • 72 (a)
OneToOne
zgc56033 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012962 35
  • 58.49 (n)
  • 55.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10298 35
  • 59.8 (n)
  • 58.18 (a)
CG10298 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F40A3.3 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7271 36
  • 48 (a)
OneToOne
Species with no ortholog for PEBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEBP1 Gene

ENSEMBL:
Gene Tree for PEBP1 (if available)
TreeFam:
Gene Tree for PEBP1 (if available)

Paralogs for PEBP1 Gene

Paralogs for PEBP1 Gene

Selected SIMAP similar genes for PEBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PEBP1 Gene

genes like me logo Genes that share paralogs with PEBP1: view

Variants for PEBP1 Gene

Sequence variations from dbSNP and Humsavar for PEBP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13893 -- 118,144,837(+) TGGAG(C/G)CCCCA utr-variant-3-prime
rs904661 -- 118,144,055(-) CAAAA(C/T)TTACT intron-variant
rs904662 -- 118,144,028(-) GGACT(A/G)CTTCG intron-variant
rs1050547 -- 118,136,150(+) CGCCT(C/T)TGTCG utr-variant-5-prime
rs1050555 -- 118,136,285(+) CGCTG(A/C)ATGTC missense, reference

Relevant External Links for PEBP1 Gene

HapMap Linkage Disequilibrium report
PEBP1
Human Gene Mutation Database (HGMD)
PEBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PEBP1 Gene

Disorders for PEBP1 Gene

(10) Novoseek inferred disease relationships for PEBP1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 40.3 23
alzheimers disease 33.6 7
prostate cancer 32.3 11
primary tumor 21.2 1
melanoma 20.8 9

Relevant External Links for PEBP1

Genetic Association Database (GAD)
PEBP1
genes like me logo Genes that share disorders with PEBP1: view

No data available for UniProtKB/Swiss-Prot for PEBP1 Gene

Publications for PEBP1 Gene

  1. Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. (PMID: 7807553) Seddiqi N. … Schoentgen F. (J. Mol. Evol. 1994) 3 4 23
  2. A human cDNA sequence homologue of bovine phosphatidylethanolamine- binding protein. (PMID: 8144042) Hori N. … Matsubara K. (Gene 1994) 3 4 23
  3. Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction. (PMID: 9782050) Banfield M.J. … Brady R.L. (Structure 1998) 3 4 23
  4. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. (PMID: 7637590) Tohdoh N. … Ojika K. (Brain Res. Mol. Brain Res. 1995) 3 4 23
  5. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. (PMID: 11585904) Yeung K.C. … Sedivy J.M. (Mol. Cell. Biol. 2001) 3 23

Products for PEBP1 Gene

Sources for PEBP1 Gene

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