Aliases for PEBP1 Gene
External Ids for PEBP1 Gene
Previous HGNC Symbols for PEBP1 Gene
Previous GeneCards Identifiers for PEBP1 Gene
GeneCards Summary for PEBP1 Gene
PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and ErbB1 downstream signaling. GO annotations related to this gene include protein kinase binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PEBP4.
UniProtKB/Swiss-Prot for PEBP1 Gene
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).