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Aliases for PA2G4 Gene

Aliases for PA2G4 Gene

  • Proliferation-Associated 2G4, 38kDa 2 3
  • Proliferation-Associated 2G4, 38kD 2 3
  • Cell Cycle Protein P38-2G4 Homolog 3 4
  • ErbB3-Binding Protein 1 3 4
  • HG4-1 3 4
  • EBP1 3 4
  • Proliferation-Associated Protein 2G4 3
  • ErbB3-Binding Protein Ebp1 3
  • ErbB-3 Binding Protein 1 3
  • P38-2G4 3

External Ids for PA2G4 Gene

Previous GeneCards Identifiers for PA2G4 Gene

  • GC12M056378
  • GC12M056832
  • GC12P056215
  • GC12P054784
  • GC12P056498
  • GC12P053543

Summaries for PA2G4 Gene

Entrez Gene Summary for PA2G4 Gene

  • This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PA2G4 Gene

PA2G4 (Proliferation-Associated 2G4, 38kDa) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot for PA2G4 Gene

  • May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Gene Wiki entry for PA2G4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PA2G4 Gene

Genomics for PA2G4 Gene

Regulatory Elements for PA2G4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PA2G4 Gene

Start:
56,104,319 bp from pter
End:
56,113,910 bp from pter
Size:
9,592 bases
Orientation:
Plus strand

Genomic View for PA2G4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PA2G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PA2G4 Gene

Proteins for PA2G4 Gene

  • Protein details for PA2G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ80-PA2G4_HUMAN
    Recommended name:
    Proliferation-associated protein 2G4
    Protein Accession:
    Q9UQ80
    Secondary Accessions:
    • O43846
    • Q9UM59

    Protein attributes for PA2G4 Gene

    Size:
    394 amino acids
    Molecular mass:
    43787 Da
    Quaternary structure:
    • Isoform 2 interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Interacts with AKT1 (By similarity). Isoform 1 and isoform 2 interact with RNF20. Isoform 2 interacts with HUWE1.

    Three dimensional structures from OCA and Proteopedia for PA2G4 Gene

    Alternative splice isoforms for PA2G4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PA2G4 Gene

Proteomics data for PA2G4 Gene at MOPED

Post-translational modifications for PA2G4 Gene

  • In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.
  • Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.
  • Ubiquitination at Lys20, Lys158, Lys172, Lys253, Lys344, and Lys376
  • Modification sites at PhosphoSitePlus

Other Protein References for PA2G4 Gene

Antibody Products

No data available for DME Specific Peptides for PA2G4 Gene

Domains for PA2G4 Gene

Protein Domains for PA2G4 Gene

Suggested Antigen Peptide Sequences for PA2G4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ80

UniProtKB/Swiss-Prot:

PA2G4_HUMAN :
  • Q9UQ80
Family:
  • Belongs to the peptidase M24 family.
genes like me logo Genes that share domains with PA2G4: view

No data available for Gene Families for PA2G4 Gene

Function for PA2G4 Gene

Molecular function for PA2G4 Gene

GENATLAS Biochemistry: murine cell-cycle P38-2G4 homolog,confined to the nucleus during interphase and cytoplasmic from metaphase through to telophase,widely expressed
UniProtKB/Swiss-Prot Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15073182
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 15073182
GO:0005515 protein binding IPI 11268000
GO:0016787 hydrolase activity --
GO:0031625 ubiquitin protein ligase binding IPI 19037095
genes like me logo Genes that share ontologies with PA2G4: view
genes like me logo Genes that share phenotypes with PA2G4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PA2G4 Gene

Localization for PA2G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PA2G4 Gene

Isoform 1: Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269 PubMed:16832058}.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PA2G4 Gene COMPARTMENTS Subcellular localization image for PA2G4 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 16832058
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PA2G4: view

Pathways for PA2G4 Gene

genes like me logo Genes that share pathways with PA2G4: view

Pathways by source for PA2G4 Gene

1 BioSystems pathway for PA2G4 Gene

Gene Ontology (GO) - Biological Process for PA2G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006364 rRNA processing IEA --
GO:0006417 regulation of translation IEA --
GO:0007050 cell cycle arrest TAS 7556453
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with PA2G4: view

Compounds for PA2G4 Gene

(1) Novoseek inferred chemical compound relationships for PA2G4 Gene

Compound -log(P) Hits PubMed IDs
testosterone 32.1 8
genes like me logo Genes that share compounds with PA2G4: view

Transcripts for PA2G4 Gene

Unigene Clusters for PA2G4 Gene

Proliferation-associated 2G4, 38kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PA2G4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PA2G4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for PA2G4 Gene

GeneLoc Exon Structure for
PA2G4
ECgene alternative splicing isoforms for
PA2G4

Expression for PA2G4 Gene

mRNA expression in normal human tissues for PA2G4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PA2G4 Gene

SOURCE GeneReport for Unigene cluster for PA2G4 Gene Hs.524498

mRNA Expression by UniProt/SwissProt for PA2G4 Gene

Q9UQ80-PA2G4_HUMAN
Tissue specificity: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
genes like me logo Genes that share expressions with PA2G4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PA2G4 Gene

Orthologs for PA2G4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PA2G4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PA2G4 35
  • 99.83 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PA2G4 35
  • 95.85 (n)
  • 99.75 (a)
PA2G4 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
PA2G4 35
  • 96.53 (n)
  • 99.75 (a)
mouse
(Mus musculus)
Mammalia Pa2g4 35
  • 92.13 (n)
  • 98.98 (a)
Pa2g4 16
Pa2g4 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pa2g4 35
  • 91.88 (n)
  • 98.98 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 94 (a)
OneToMany
PA2G4 35
  • 81.32 (n)
  • 92.31 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8907 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pa2g4 35
  • 78.95 (n)
  • 90.72 (a)
Str.671 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9574 35
zebrafish
(Danio rerio)
Actinopterygii pa2g4a 35
  • 76.96 (n)
  • 86.28 (a)
pa2g4a 36
  • 84 (a)
ManyToMany
pa2g4b 36
  • 83 (a)
ManyToMany
wufb37h04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005108 35
  • 58.76 (n)
  • 55.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10576 35
  • 58.26 (n)
  • 56.3 (a)
CG10576 36
  • 53 (a)
OneToMany
CG10576 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea W08E12.7 35
  • 54.22 (n)
  • 49.58 (a)
W08E12.7 36
  • 47 (a)
OneToMany
W08E12.7 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARX1 38
MAP2 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG2 35
  • 58.14 (n)
  • 52.59 (a)
rice
(Oryza sativa)
Liliopsida Os05g0350500 35
  • 57.9 (n)
  • 52.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00422 35
  • 46.33 (n)
  • 34.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdb4 35
  • 49.7 (n)
  • 43.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10766 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6876 36
  • 56 (a)
OneToMany
Species with no ortholog for PA2G4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PA2G4 Gene

ENSEMBL:
Gene Tree for PA2G4 (if available)
TreeFam:
Gene Tree for PA2G4 (if available)

Paralogs for PA2G4 Gene

Paralogs for PA2G4 Gene

Selected SIMAP similar genes for PA2G4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PA2G4: view

Variants for PA2G4 Gene

Sequence variations from dbSNP and Humsavar for PA2G4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs773120 -- 56,109,142(-) TGAGC(A/G)ttttt intron-variant
rs773121 -- 56,104,457(-) CGCTC(C/T)TAAGC utr-variant-5-prime
rs3759094 -- 56,104,119(+) TTCGC(C/T)AGCCG upstream-variant-2KB
rs3759095 -- 56,104,154(+) ACCCA(C/G)CCTCC upstream-variant-2KB
rs7976197 -- 56,110,284(+) ggacc(C/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PA2G4 Gene

Variant ID Type Subtype PubMed ID
nsv832427 CNV Loss 17160897

Relevant External Links for PA2G4 Gene

HapMap Linkage Disequilibrium report
PA2G4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PA2G4 Gene

Disorders for PA2G4 Gene

(4) Novoseek inferred disease relationships for PA2G4 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 41.3 10
retinoblastoma 34.7 1
breast cancer 24.9 15
tumors 0 3
genes like me logo Genes that share disorders with PA2G4: view

No data available for UniProtKB/Swiss-Prot for PA2G4 Gene

Publications for PA2G4 Gene

  1. Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4. (PMID: 9345902) Lamartine J. … Sylla B.S. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. (PMID: 10682683) Yoo J.Y. … Hamburger A.W. (Br. J. Cancer 2000) 3 4 23
  3. Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. (PMID: 11268000) Xia X. … Hamburger A.W. (J. Cell. Physiol. 2001) 3 4 23
  4. Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases. (PMID: 12682367) Zhang Y. … Hamburger A.W. (Nucleic Acids Res. 2003) 3 4 23
  5. Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling. (PMID: 15583694) Zhang Y. … Hamburger A.W. (Br. J. Cancer 2005) 3 4 23

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