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Aliases for P2RY6 Gene

Aliases for P2RY6 Gene

  • Pyrimidinergic Receptor P2Y6 2 3
  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 2 3 5
  • P2Y6 3 4
  • G-Coupled Nucleotide Receptor 3
  • P2 Purinoceptor 3
  • P2Y6 Receptor 3

External Ids for P2RY6 Gene

Previous GeneCards Identifiers for P2RY6 Gene

  • GC11P075241
  • GC11P074515
  • GC11P073198
  • GC11P072701
  • GC11P072653
  • GC11P072975
  • GC11P069270

Summaries for P2RY6 Gene

Entrez Gene Summary for P2RY6 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY6 Gene

P2RY6 (Pyrimidinergic Receptor P2Y6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for P2RY6 Gene

  • Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for P2RY6 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY6 Gene

Genomics for P2RY6 Gene

Regulatory Elements for P2RY6 Gene

Promoters for P2RY6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RY6 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY6 Gene

Chromosome:
11
Start:
73,264,496 bp from pter
End:
73,298,625 bp from pter
Size:
34,130 bases
Orientation:
Plus strand

Genomic View for P2RY6 Gene

Genes around P2RY6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY6 Gene

Proteins for P2RY6 Gene

  • Protein details for P2RY6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15077-P2RY6_HUMAN
    Recommended name:
    P2Y purinoceptor 6
    Protein Accession:
    Q15077
    Secondary Accessions:
    • Q15754

    Protein attributes for P2RY6 Gene

    Size:
    328 amino acids
    Molecular mass:
    36429 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY6 Gene

neXtProt entry for P2RY6 Gene

Proteomics data for P2RY6 Gene at MOPED

Post-translational modifications for P2RY6 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for P2RY6 Gene

Domains & Families for P2RY6 Gene

Gene Families for P2RY6 Gene

Protein Domains for P2RY6 Gene

Suggested Antigen Peptide Sequences for P2RY6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15077

UniProtKB/Swiss-Prot:

P2RY6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY6: view

Function for P2RY6 Gene

Molecular function for P2RY6 Gene

GENATLAS Biochemistry:
purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell lines,predominantly responding to ATP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045029 UDP-activated nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY6: view
genes like me logo Genes that share phenotypes with P2RY6: view

Animal Models for P2RY6 Gene

MGI Knock Outs for P2RY6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY6 Gene

Localization for P2RY6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY6 Gene COMPARTMENTS Subcellular localization image for P2RY6 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY6: view

Pathways & Interactions for P2RY6 Gene

genes like me logo Genes that share pathways with P2RY6: view

Pathways by source for P2RY6 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY6 Gene
1 Qiagen pathway for P2RY6 Gene

Gene Ontology (GO) - Biological Process for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8670200
GO:0014911 positive regulation of smooth muscle cell migration IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY6: view

No data available for SIGNOR curated interactions for P2RY6 Gene

Drugs & Compounds for P2RY6 Gene

(26) Drugs for P2RY6 Gene - From: Novoseek, IUPHAR, DGIdb, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine triphosphate Experimental Pharma 0
MC-1 Investigational Pharma 0
2MeSATP Pharma Antagonist 0
3-phenacyl-UDP Pharma Full agonist, Agonist 0
5BrUTP Pharma Full agonist, Agonist 0

(19) Additional Compounds for P2RY6 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
5-iodoUDP
Full agonist, Agonist
UDP
Agonist
UDP-beta-S
Full agonist, Agonist
UTP
Full agonist, Agonist

(5) Tocris Compounds for P2RY6 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3

(1) ApexBio Compounds for P2RY6 Gene

Compound Action Cas Number
MRS 2578 P2Y6 receptor antagonist,potent and selective 711019-86-2
genes like me logo Genes that share compounds with P2RY6: view

Transcripts for P2RY6 Gene

Unigene Clusters for P2RY6 Gene

Pyrimidinergic receptor P2Y, G-protein coupled, 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: -

Relevant External Links for P2RY6 Gene

GeneLoc Exon Structure for
P2RY6
ECgene alternative splicing isoforms for
P2RY6

Expression for P2RY6 Gene

mRNA expression in normal human tissues for P2RY6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY6 Gene

This gene is overexpressed in Spleen (x15.7).

SOURCE GeneReport for Unigene cluster for P2RY6 Gene Hs.16362

genes like me logo Genes that share expression patterns with P2RY6: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for P2RY6 Gene

Orthologs for P2RY6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RY6 35
  • 89.53 (n)
  • 92.68 (a)
P2RY6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY6 35
  • 88.62 (n)
  • 94.15 (a)
P2RY6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry6 35
  • 84.15 (n)
  • 87.12 (a)
P2ry6 16
P2ry6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia P2RY6 35
  • 99.09 (n)
  • 99.39 (a)
P2RY6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry6 35
  • 84.56 (n)
  • 88.04 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY6 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY6 35
  • 70.2 (n)
  • 63.67 (a)
P2RY3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY6 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC566099 35
  • 60.85 (n)
  • 61.59 (a)
P2RY6 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7925 35
Species with no ortholog for P2RY6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY6 Gene

ENSEMBL:
Gene Tree for P2RY6 (if available)
TreeFam:
Gene Tree for P2RY6 (if available)

Paralogs for P2RY6 Gene

genes like me logo Genes that share paralogs with P2RY6: view

Variants for P2RY6 Gene

Sequence variations from dbSNP and Humsavar for P2RY6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs623194 -- 73,293,932(-) AGAGG(G/T)TTGTG intron-variant
rs623627 -- 73,293,838(-) GACAG(C/T)CCTCT intron-variant
rs868175 -- 73,288,041(+) TCTTC(A/G)TTCAC intron-variant
rs882904 -- 73,286,865(-) CATGA(A/C/T)ACCCT intron-variant
rs1045124 -- 73,297,661(+) TATTT(C/T)TTCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for P2RY6 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv387 CNV Insertion 18451855
nsv520665 CNV Loss 19592680

Variation tolerance for P2RY6 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY6 Gene

HapMap Linkage Disequilibrium report
P2RY6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY6 Gene

Disorders for P2RY6 Gene

Relevant External Links for P2RY6

Genetic Association Database (GAD)
P2RY6
Human Genome Epidemiology (HuGE) Navigator
P2RY6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY6

No disorders were found for P2RY6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY6 Gene

Publications for P2RY6 Gene

  1. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PMID: 8670200) Communi D. … Boeynaems J.-M. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PMID: 19124756) Jiang Y. … Boyce J.A. (J. Immunol. 2009) 3 23
  3. Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. (PMID: 18250478) Grbic D.M. … Gendron F.P. (J. Immunol. 2008) 3 23
  4. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. (PMID: 19008857) Nishida M. … Kurose H. (EMBO J. 2008) 3 23
  5. Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. (PMID: 16543499) Wihlborg A.K. … Erlinge D. (Circ. Res. 2006) 3 23

Products for P2RY6 Gene

Sources for P2RY6 Gene

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