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Aliases for P2RX4 Gene

Aliases for P2RX4 Gene

  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 4 2 3
  • P2X4 3 4 6
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 2 3
  • ATP Receptor 3 4
  • ATP-Gated Cation Channel Protein 3
  • Purinergic Receptor P2X4 3
  • P2X Receptor, Subunit 4 3
  • Purinergic Receptor 4
  • P2X Purinoceptor 4 3
  • Purinoceptor P2X4 3
  • P2X4R 3

External Ids for P2RX4 Gene

Previous GeneCards Identifiers for P2RX4 Gene

  • GC12P120510
  • GC12P121227
  • GC12P121430
  • GC12P120059
  • GC12P120110
  • GC12P121647
  • GC12P118657

Summaries for P2RX4 Gene

Entrez Gene Summary for P2RX4 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for P2RX4 Gene

P2RX4 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 4) is a Protein Coding gene. Diseases associated with P2RX4 include chronic pain. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX4 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Tocris Summary for P2RX4 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility and nociception.

Gene Wiki entry for P2RX4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX4 Gene

Genomics for P2RX4 Gene

Regulatory Elements for P2RX4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RX4 Gene

121,209,857 bp from pter
121,234,106 bp from pter
24,250 bases
Plus strand

Genomic View for P2RX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX4 Gene

Proteins for P2RX4 Gene

  • Protein details for P2RX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2X purinoceptor 4
    Protein Accession:
    Secondary Accessions:
    • E7EPF7
    • F6RU17
    • O00450
    • O14722
    • Q5U089
    • Q5U090
    • Q8N4N1
    • Q9UBG9

    Protein attributes for P2RX4 Gene

    388 amino acids
    Molecular mass:
    43369 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

    Alternative splice isoforms for P2RX4 Gene


neXtProt entry for P2RX4 Gene

Proteomics data for P2RX4 Gene at MOPED

Post-translational modifications for P2RX4 Gene

  • Glycosylation at Asn75, Asn110, Asn153, Asn184, Asn199, and Asn208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for P2RX4 (P2X4)

No data available for DME Specific Peptides for P2RX4 Gene

Domains for P2RX4 Gene

Gene Families for P2RX4 Gene

Protein Domains for P2RX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the P2X receptor family.
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX4: view

Function for P2RX4 Gene

Molecular function for P2RX4 Gene

GENATLAS Biochemistry:
purinoceptor,P2X4,ionotropic class,expressed in heart and spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Gene Ontology (GO) - Molecular Function for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity IMP 11606481
GO:0004931 extracellular ATP-gated cation channel activity IDA 10515189
GO:0005102 receptor binding ISS 17785580
GO:0005216 ion channel activity --
GO:0005507 copper ion binding ISS 12819199
genes like me logo Genes that share ontologies with P2RX4: view
genes like me logo Genes that share phenotypes with P2RX4: view

Animal Models for P2RX4 Gene

MGI Knock Outs for P2RX4:

Animal Model Products

CRISPR Products

miRNA for P2RX4 Gene

miRTarBase miRNAs that target P2RX4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for P2RX4 Gene

Localization for P2RX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for P2RX4 Gene COMPARTMENTS Subcellular localization image for P2RX4 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
extracellular 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane ISS 17785580
GO:0005887 integral component of plasma membrane IMP 10515189
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with P2RX4: view

Pathways for P2RX4 Gene

genes like me logo Genes that share pathways with P2RX4: view

Pathways by source for P2RX4 Gene

1 Qiagen pathway for P2RX4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis NAS 17264311
GO:0002028 regulation of sodium ion transport ISS 17785580
GO:0006809 nitric oxide biosynthetic process IEA --
GO:0006810 transport IDA 9016352
GO:0006811 ion transport --
genes like me logo Genes that share ontologies with P2RX4: view

Drugs for P2RX4 Gene

(5) Tocris Compounds for P2RX4 Gene

Compound Action Cas Number
A 438079 hydrochloride Competitive P2X7 antagonist [899431-18-6]
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog [93839-89-5]
NF 449 Highly selective P2X1 antagonist [627034-85-9]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]
TNP-ATP triethylammonium salt Potent, selective P2X antagonist [61368-63-6]

(2) ApexBio Compounds for P2RX4 Gene

Compound Action Cas Number
Ivermectin NAChR/purinergic P2X4 receptor modulator [70288-86-7]
KN-93 CaMKII inhibitor,selective and cometitive [139298-40-1]

(9) Novoseek inferred chemical compound relationships for P2RX4 Gene

Compound -log(P) Hits PubMed IDs
alpha,beta methylene atp 81.2 1
bzatp 77.4 1
atp 75.7 17
suramin 69.7 2
ppads 66.4 1
genes like me logo Genes that share compounds with P2RX4: view

Transcripts for P2RX4 Gene

Unigene Clusters for P2RX4 Gene

Purinergic receptor P2X, ligand-gated ion channel, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for P2RX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RX4 Gene

mRNA expression in normal human tissues for P2RX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for P2RX4 Gene

This gene is overexpressed in Liver (22.4), Islet of Langerhans (10.6), and Placenta (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for P2RX4 Gene

SOURCE GeneReport for Unigene cluster for P2RX4 Gene Hs.321709

genes like me logo Genes that share expressions with P2RX4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for P2RX4 Gene

Orthologs for P2RX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia P2RX4 35
  • 87.71 (n)
  • 87.37 (a)
P2RX4 36
  • 87 (a)
(Canis familiaris)
Mammalia P2RX4 35
  • 89 (n)
  • 89.95 (a)
P2X4 36
  • 90 (a)
(Mus musculus)
Mammalia P2rx4 35
  • 85.4 (n)
  • 87.37 (a)
P2rx4 16
P2rx4 36
  • 87 (a)
(Pan troglodytes)
Mammalia P2RX4 35
  • 99.48 (n)
  • 100 (a)
P2RX4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia P2rx4 35
  • 86 (n)
  • 87.11 (a)
(Monodelphis domestica)
Mammalia P2RX4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia P2RX4 36
  • 67 (a)
(Gallus gallus)
Aves P2RX4 35
  • 74.67 (n)
  • 76.76 (a)
P2RX4 36
  • 76 (a)
(Anolis carolinensis)
Reptilia P2RX4 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia p2rx4 35
  • 68.5 (n)
  • 69.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398206 35
(Danio rerio)
Actinopterygii p2rx4a 35
  • 61.28 (n)
  • 59.37 (a)
p2rx4a 36
  • 57 (a)
p2rx4b 36
  • 50 (a)
Species with no ortholog for P2RX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX4 Gene

Gene Tree for P2RX4 (if available)
Gene Tree for P2RX4 (if available)

Paralogs for P2RX4 Gene

Paralogs for P2RX4 Gene

(7) SIMAP similar genes for P2RX4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with P2RX4: view

Variants for P2RX4 Gene

Sequence variations from dbSNP and Humsavar for P2RX4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs111350288 -- 121,220,179(+) CCCAT(C/G)AGGCC intron-variant
rs111527450 -- 121,234,420(+) ATGCC(C/T)GGCTA downstream-variant-500B
rs111551828 -- 121,217,378(+) CTGAC(A/G)TCACC intron-variant
rs111249465 -- 121,231,828(+) GTGAA(A/G)CCCCG intron-variant
rs80336176 -- 121,231,550(+) TTTTG(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RX4 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899564 CNV Loss 21882294
nsv899565 CNV Gain+Loss 21882294
nsv455731 CNV Loss 19166990

Relevant External Links for P2RX4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX4 Gene

Disorders for P2RX4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for P2RX4 Gene in MalaCards »

(1) Disease for P2RX4 Gene

Relevant External Links for P2RX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with P2RX4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for P2RX4 Gene

Publications for P2RX4 Gene

  1. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PMID: 18852390) Palomino-Doza J. … Keavney B. (Hypertension 2008) 3 23 48
  2. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M. … Stuhmer W. (Mol. Pharmacol. 1997) 2 3 4
  3. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. (PMID: 19552691) Wareham K. … Seward E.P. (Br. J. Pharmacol. 2009) 3 23
  4. Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity. (PMID: 19562525) Varma R. … Haughey N.J. (Neuromolecular Med. 2009) 3 23
  5. Site-specific splice variation of the human P2X4 receptor. (PMID: 10515189) Carpenter D. … Sanger G.J. (Neurosci. Lett. 1999) 3 4

Products for P2RX4 Gene

Sources for P2RX4 Gene

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