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Aliases for P2RX4 Gene

Aliases for P2RX4 Gene

  • Purinergic Receptor P2X 4 2 3
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 2 3
  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 4 3 5
  • ATP Receptor 3 4
  • P2X4 3 4
  • ATP-Gated Cation Channel Protein 3
  • Purinergic Receptor P2X4 3
  • P2X Receptor, Subunit 4 3
  • Purinergic Receptor 4
  • Purinoceptor P2X4 3
  • P2X4R 3

External Ids for P2RX4 Gene

Previous GeneCards Identifiers for P2RX4 Gene

  • GC12P120510
  • GC12P121227
  • GC12P121430
  • GC12P120059
  • GC12P120110
  • GC12P121647
  • GC12P118657
  • GC12P121229
  • GC12P121281

Summaries for P2RX4 Gene

Entrez Gene Summary for P2RX4 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for P2RX4 Gene

P2RX4 (Purinergic Receptor P2X 4) is a Protein Coding gene. Diseases associated with P2RX4 include chronic pain. Among its related pathways are Platelet activation, signaling and aggregation and CREB Pathway. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX4 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Tocris Summary for P2RX4 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX4 Gene

Genomics for P2RX4 Gene

Regulatory Elements for P2RX4 Gene

Promoters for P2RX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RX4 Gene

Chromosome:
12
Start:
121,209,857 bp from pter
End:
121,234,106 bp from pter
Size:
24,250 bases
Orientation:
Plus strand

Genomic View for P2RX4 Gene

Genes around P2RX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX4 Gene

Proteins for P2RX4 Gene

  • Protein details for P2RX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99571-P2RX4_HUMAN
    Recommended name:
    P2X purinoceptor 4
    Protein Accession:
    Q99571
    Secondary Accessions:
    • E7EPF7
    • F6RU17
    • O00450
    • O14722
    • Q5U089
    • Q5U090
    • Q8N4N1
    • Q9UBG9

    Protein attributes for P2RX4 Gene

    Size:
    388 amino acids
    Molecular mass:
    43369 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

    Alternative splice isoforms for P2RX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for P2RX4 Gene

Proteomics data for P2RX4 Gene at MOPED

Post-translational modifications for P2RX4 Gene

  • Glycosylation at Asn 75, Asn 110, Asn 153, Asn 184, Asn 199, and Asn 208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for P2RX4 (P2X4)

No data available for DME Specific Peptides for P2RX4 Gene

Domains & Families for P2RX4 Gene

Gene Families for P2RX4 Gene

Protein Domains for P2RX4 Gene

Graphical View of Domain Structure for InterPro Entry

Q99571

UniProtKB/Swiss-Prot:

P2RX4_HUMAN :
  • Belongs to the P2X receptor family.
Family:
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX4: view

Function for P2RX4 Gene

Molecular function for P2RX4 Gene

GENATLAS Biochemistry:
purinoceptor,P2X4,ionotropic class,expressed in heart and spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Gene Ontology (GO) - Molecular Function for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with P2RX4: view
genes like me logo Genes that share phenotypes with P2RX4: view

Animal Models for P2RX4 Gene

MGI Knock Outs for P2RX4:

Animal Model Products

CRISPR Products

miRNA for P2RX4 Gene

miRTarBase miRNAs that target P2RX4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX4 Gene

Localization for P2RX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RX4 Gene COMPARTMENTS Subcellular localization image for P2RX4 gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005886 plasma membrane ISS,TAS --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IDA 17785580
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with P2RX4: view

Pathways & Interactions for P2RX4 Gene

genes like me logo Genes that share pathways with P2RX4: view

Pathways by source for P2RX4 Gene

Gene Ontology (GO) - Biological Process for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis NAS 17264311
GO:0002028 regulation of sodium ion transport ISS 17785580
GO:0007165 signal transduction IDA 9016352
GO:0007596 blood coagulation TAS --
GO:0008217 regulation of blood pressure IMP 11606481
genes like me logo Genes that share ontologies with P2RX4: view

No data available for SIGNOR curated interactions for P2RX4 Gene

Drugs & Compounds for P2RX4 Gene

(7) Drugs for P2RX4 Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ivermectin Approved Pharma NAChR/purinergic P2X4 receptor modulator 47
KN-93 Pharma CaMKII inhibitor,selective and cometitive 0

(9) Additional Compounds for P2RX4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methylthioadenosine triphosphate tetrasodium salt
100020-57-3
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt
1343364-54-4
ATP disodium salt
987-65-5
ATPgammaS tetralithium salt
93839-89-5
BzATP triethylammonium salt
112898-15-4
genes like me logo Genes that share compounds with P2RX4: view

Transcripts for P2RX4 Gene

Unigene Clusters for P2RX4 Gene

Purinergic receptor P2X, ligand-gated ion channel, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: -
SP9:

Relevant External Links for P2RX4 Gene

GeneLoc Exon Structure for
P2RX4
ECgene alternative splicing isoforms for
P2RX4

Expression for P2RX4 Gene

mRNA expression in normal human tissues for P2RX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for P2RX4 Gene

This gene is overexpressed in Liver (22.4), Islet of Langerhans (10.6), and Placenta (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for P2RX4 Gene



SOURCE GeneReport for Unigene cluster for P2RX4 Gene Hs.321709

genes like me logo Genes that share expression patterns with P2RX4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for P2RX4 Gene

Orthologs for P2RX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RX4 35
  • 87.71 (n)
  • 87.37 (a)
P2RX4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RX4 35
  • 89 (n)
  • 89.95 (a)
P2X4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2rx4 35
  • 85.4 (n)
  • 87.37 (a)
P2rx4 16
P2rx4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia P2RX4 35
  • 99.48 (n)
  • 100 (a)
P2RX4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2rx4 35
  • 86 (n)
  • 87.11 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RX4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RX4 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RX4 35
  • 74.67 (n)
  • 76.76 (a)
P2RX4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RX4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2rx4 35
  • 68.5 (n)
  • 69.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398206 35
zebrafish
(Danio rerio)
Actinopterygii p2rx4a 35
  • 61.28 (n)
  • 59.37 (a)
p2rx4a 36
  • 57 (a)
OneToMany
p2rx4b 36
  • 50 (a)
OneToMany
Species with no ortholog for P2RX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX4 Gene

ENSEMBL:
Gene Tree for P2RX4 (if available)
TreeFam:
Gene Tree for P2RX4 (if available)

Paralogs for P2RX4 Gene

Paralogs for P2RX4 Gene

(7) SIMAP similar genes for P2RX4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with P2RX4: view

Variants for P2RX4 Gene

Sequence variations from dbSNP and Humsavar for P2RX4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs25644 - 121,228,843(+) GACAC(A/G)GTTTC nc-transcript-variant, downstream-variant-500B, reference, missense
VAR_028307 -
rs25642 -- 121,222,114(+) ACTGT(A/G)TGTAA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs25643 -- 121,222,984(+) GGGTC(A/C/G/T)GTCAA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs725135 -- 121,224,474(-) CAGAC(A/G)AGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RX4 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899564 CNV Loss 21882294
nsv899565 CNV Gain+Loss 21882294
nsv455731 CNV Loss 19166990

Variation tolerance for P2RX4 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.90; 83.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RX4 Gene

HapMap Linkage Disequilibrium report
P2RX4
Human Gene Mutation Database (HGMD)
P2RX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX4 Gene

Disorders for P2RX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RX4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic pain
  • pain - chronic
- elite association - COSMIC cancer census association via MalaCards
Search P2RX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RX4

Genetic Association Database (GAD)
P2RX4
Human Genome Epidemiology (HuGE) Navigator
P2RX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RX4
genes like me logo Genes that share disorders with P2RX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX4 Gene

Publications for P2RX4 Gene

  1. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M. … Stuhmer W. (Mol. Pharmacol. 1997) 2 3 4 67
  2. Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation. (PMID: 19283779) Stokes L. … Surprenant A. (Eur. J. Immunol. 2009) 3 23
  3. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. (PMID: 19552691) Wareham K. … Seward E.P. (Br. J. Pharmacol. 2009) 3 23
  4. Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity. (PMID: 19562525) Varma R. … Haughey N.J. (Neuromolecular Med. 2009) 3 23
  5. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PMID: 18852390) Palomino-Doza J. … Keavney B. (Hypertension 2008) 3 23

Products for P2RX4 Gene

Sources for P2RX4 Gene

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