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Aliases for P2RX3 Gene

Aliases for P2RX3 Gene

  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 3 2 3
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 3 2 3
  • ATP Receptor 3 4
  • P2X3 3 4
  • Purinergic Receptor P2X3 3
  • P2X Receptor, Subunit 3 3
  • Purinergic Receptor 4
  • Purinoceptor P2X3 3

External Ids for P2RX3 Gene

Previous GeneCards Identifiers for P2RX3 Gene

  • GC11P059499
  • GC11P058618
  • GC11P056881
  • GC11P056862
  • GC11P057105
  • GC11P053454

Summaries for P2RX3 Gene

Entrez Gene Summary for P2RX3 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RX3 Gene

P2RX3 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 3) is a Protein Coding gene. Diseases associated with P2RX3 include chronic interstitial cystitis and bladder disease. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include ion channel activity and extracellular ATP-gated cation channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX3 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel

Tocris Summary for P2RX3 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX3 Gene

Genomics for P2RX3 Gene

Regulatory Elements for P2RX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RX3 Gene

57,335,946 bp from pter
57,372,399 bp from pter
36,454 bases
Plus strand

Genomic View for P2RX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX3 Gene

Proteins for P2RX3 Gene

  • Protein details for P2RX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2X purinoceptor 3
    Protein Accession:
    Secondary Accessions:
    • Q6DK37
    • Q9UQB6

    Protein attributes for P2RX3 Gene

    397 amino acids
    Molecular mass:
    44289 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

neXtProt entry for P2RX3 Gene

Proteomics data for P2RX3 Gene at MOPED

Post-translational modifications for P2RX3 Gene

  • Glycosylation at Asn 139, Asn 170, Asn 194, and Asn 290
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for P2RX3 Gene

Domains & Families for P2RX3 Gene

Gene Families for P2RX3 Gene

Protein Domains for P2RX3 Gene

Suggested Antigen Peptide Sequences for P2RX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the P2X receptor family.
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX3: view

Function for P2RX3 Gene

Molecular function for P2RX3 Gene

GENATLAS Biochemistry:
purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory neurons,fibers,running into the spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel

Gene Ontology (GO) - Molecular Function for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity NAS 17895406
GO:0004931 extracellular ATP-gated cation channel activity NAS 17895406
GO:0005524 ATP binding NAS 17895406
genes like me logo Genes that share ontologies with P2RX3: view
genes like me logo Genes that share phenotypes with P2RX3: view

Animal Models for P2RX3 Gene

MGI Knock Outs for P2RX3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for P2RX3 Gene

Localization for P2RX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for P2RX3 Gene COMPARTMENTS Subcellular localization image for P2RX3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with P2RX3: view

Pathways & Interactions for P2RX3 Gene

genes like me logo Genes that share pathways with P2RX3: view

Pathways by source for P2RX3 Gene

1 Qiagen pathway for P2RX3 Gene

Interacting Proteins for P2RX3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000263314 P56373-P2RX3_HUMAN for P2RX3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006810 transport TAS 9221902
GO:0006811 ion transport --
GO:0006812 cation transport IBA --
GO:0007165 signal transduction TAS 9221902
genes like me logo Genes that share ontologies with P2RX3: view

No data available for SIGNOR curated interactions for P2RX3 Gene

Drugs & Compounds for P2RX3 Gene

(19) Drugs for P2RX3 Gene - From: NovoSeek, IUPHAR, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ivermectin Approved Pharma NAChR/purinergic P2X4 receptor modulator, Allosteric modulator of alpha7 nicotinic receptors 45
Ethanol Approved Pharma 1708
Nitric Oxide Approved Pharma 540
Suramin Approved Pharma Activator 18
Zinc Approved Pharma 1404

(8) Additional Compounds for P2RX3 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
BzATP triethylammonium salt
NF 023
NF 449
Suramin hexasodium salt
genes like me logo Genes that share compounds with P2RX3: view

Transcripts for P2RX3 Gene

mRNA/cDNA for P2RX3 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RX3 Gene

Purinergic receptor P2X, ligand-gated ion channel, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -

Relevant External Links for P2RX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RX3 Gene

mRNA expression in normal human tissues for P2RX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RX3 Gene

This gene is overexpressed in Testis (x27.7) and Heart - Left Ventricle (x13.0).

Protein differential expression in normal tissues from HIPED for P2RX3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RX3 Gene

SOURCE GeneReport for Unigene cluster for P2RX3 Gene Hs.146738

genes like me logo Genes that share expression patterns with P2RX3: view

Protein tissue co-expression partners for P2RX3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for P2RX3 Gene

Orthologs for P2RX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia P2RX3 35
  • 87.99 (n)
  • 91.44 (a)
P2RX3 36
  • 90 (a)
(Canis familiaris)
Mammalia P2RX3 35
  • 90.26 (n)
  • 94.71 (a)
P2X3 36
  • 95 (a)
(Mus musculus)
Mammalia P2rx3 35
  • 89 (n)
  • 93.7 (a)
P2rx3 16
P2rx3 36
  • 94 (a)
(Pan troglodytes)
Mammalia P2RX3 35
  • 99.58 (n)
  • 99.75 (a)
P2RX3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia P2rx3 35
  • 88.33 (n)
  • 93.95 (a)
(Monodelphis domestica)
Mammalia P2RX3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia P2RX3 36
  • 80 (a)
(Gallus gallus)
Aves LOC423134 35
  • 71.57 (n)
  • 71.07 (a)
P2RX3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia P2RX3 36
  • 76 (a)
(Danio rerio)
Actinopterygii p2rx3b 35
  • 66.58 (n)
  • 69.47 (a)
p2rx3b 36
  • 66 (a)
Species with no ortholog for P2RX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX3 Gene

Gene Tree for P2RX3 (if available)
Gene Tree for P2RX3 (if available)

Paralogs for P2RX3 Gene

Paralogs for P2RX3 Gene

(6) SIMAP similar genes for P2RX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with P2RX3: view

Variants for P2RX3 Gene

Sequence variations from dbSNP and Humsavar for P2RX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs181564340 -- 57,352,202(+) TATAA(C/G)TTAAA intron-variant
rs181305112 -- 57,338,708(+) TGGGC(C/T)GCCTG intron-variant
rs181304217 -- 57,372,089(+) CATTA(C/T)GGTTT utr-variant-3-prime, nc-transcript-variant
rs181246519 -- 57,361,346(+) GTTAC(A/G)TAGGT intron-variant
rs183158611 -- 57,368,694(+) ATAGA(G/T)TTCCC intron-variant, nc-transcript-variant

Variation tolerance for P2RX3 Gene

Residual Variation Intolerance Score: 61.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RX3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RX3 Gene

Disorders for P2RX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for P2RX3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic interstitial cystitis
  • chronic interstitial cystitis [ambiguous]
bladder disease
  • urinary bladder disease
- elite association
Search P2RX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with P2RX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX3 Gene

Publications for P2RX3 Gene

  1. Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord. (PMID: 20335487) Kaan T.K. … McMahon S.B. (J. Neurosci. 2010) 23 67
  2. Changing P2X receptor localization on maturing sperm in the epididymides of mice, hamsters, rats, and humans: a preliminary study. (PMID: 19338992) Banks F.C. … Burnstock G. (Fertil. Steril. 2010) 23 67
  3. Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells. (PMID: 20071692) BelleannAce C. … Breton S. (Am. J. Physiol., Cell Physiol. 2010) 23 67
  4. Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. (PMID: 20437566) Grishin E.V. … Krishtal O.O. (Ann. Neurol. 2010) 23 67
  5. The neural-glial purinergic receptor ensemble in chronic pain states. (PMID: 19914722) Jarvis M.F. (Trends Neurosci. 2010) 23 67

Products for P2RX3 Gene

Sources for P2RX3 Gene

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