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Aliases for P2RX3 Gene

Aliases for P2RX3 Gene

  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 3 2 3
  • P2X3 3 4 6
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 3 2 3
  • ATP Receptor 3 4
  • Purinergic Receptor P2X3 3
  • P2X Receptor, Subunit 3 3
  • Purinergic Receptor 4
  • P2X Purinoceptor 3 3
  • Purinoceptor P2X3 3

External Ids for P2RX3 Gene

Previous GeneCards Identifiers for P2RX3 Gene

  • GC11P059499
  • GC11P058618
  • GC11P056881
  • GC11P056862
  • GC11P057105
  • GC11P053454

Summaries for P2RX3 Gene

Entrez Gene Summary for P2RX3 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RX3 Gene

P2RX3 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 3) is a Protein Coding gene. Diseases associated with P2RX3 include burning mouth syndrome. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include purinergic nucleotide receptor activity and extracellular ATP-gated cation channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX3 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel

Tocris Summary for P2RX3 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility and nociception.

Gene Wiki entry for P2RX3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX3 Gene

Genomics for P2RX3 Gene

Regulatory Elements for P2RX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RX3 Gene

57,338,367 bp from pter
57,370,600 bp from pter
32,234 bases
Plus strand

Genomic View for P2RX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX3 Gene

Proteins for P2RX3 Gene

  • Protein details for P2RX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2X purinoceptor 3
    Protein Accession:
    Secondary Accessions:
    • Q6DK37
    • Q9UQB6

    Protein attributes for P2RX3 Gene

    397 amino acids
    Molecular mass:
    44289 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

neXtProt entry for P2RX3 Gene

Proteomics data for P2RX3 Gene at MOPED

Post-translational modifications for P2RX3 Gene

  • Glycosylation at Asn139, Asn170, Asn194, and Asn290
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for P2RX3 Gene

Domains for P2RX3 Gene

Gene Families for P2RX3 Gene

Protein Domains for P2RX3 Gene

Suggested Antigen Peptide Sequences for P2RX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the P2X receptor family.
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX3: view

Function for P2RX3 Gene

Molecular function for P2RX3 Gene

GENATLAS Biochemistry:
purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory neurons,fibers,running into the spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel

Gene Ontology (GO) - Molecular Function for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity NAS 17895406
GO:0004931 extracellular ATP-gated cation channel activity NAS 17895406
GO:0005216 ion channel activity --
GO:0005524 ATP binding NAS 17895406
genes like me logo Genes that share ontologies with P2RX3: view
genes like me logo Genes that share phenotypes with P2RX3: view

Animal Models for P2RX3 Gene

MGI Knock Outs for P2RX3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RX3 Gene

Localization for P2RX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for P2RX3 Gene COMPARTMENTS Subcellular localization image for P2RX3 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with P2RX3: view

Pathways for P2RX3 Gene

genes like me logo Genes that share pathways with P2RX3: view

Pathways by source for P2RX3 Gene

1 Qiagen pathway for P2RX3 Gene

Interacting Proteins for P2RX3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000263314 P56373-P2RX3_HUMAN for P2RX3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006810 transport TAS 9221902
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007165 signal transduction TAS 9221902
genes like me logo Genes that share ontologies with P2RX3: view

Compounds for P2RX3 Gene

(5) Tocris Compounds for P2RX3 Gene

Compound Action Cas Number
A 438079 hydrochloride Competitive P2X7 antagonist [899431-18-6]
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog [93839-89-5]
NF 449 Highly selective P2X1 antagonist [627034-85-9]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]
TNP-ATP triethylammonium salt Potent, selective P2X antagonist [61368-63-6]

(1) ApexBio Compounds for P2RX3 Gene

Compound Action Cas Number
KN-93 "CaMKII inhibitor,selective and cometitive" [139298-40-1]

(6) IUPHAR Ligand for P2RX3 Gene

Ligand Type Action Affinity Pubmed IDs
TNP-ATP Antagonist Antagonist 8.9
AF353 Antagonist Antagonist 8
A317491 Antagonist Antagonist 7.5
RO3 Antagonist Antagonist 7.5
BzATP Agonist Full agonist 5.1
alphabeta-meATP Agonist Full agonist

(16) Novoseek inferred chemical compound relationships for P2RX3 Gene

Compound -log(P) Hits PubMed IDs
alpha,beta methylene atp 89.2 6
tnp-atp 75.8 2
bzatp 75.6 4
atp 75.5 36
ppads 68.8 1
genes like me logo Genes that share compounds with P2RX3: view

Transcripts for P2RX3 Gene

mRNA/cDNA for P2RX3 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RX3 Gene

Purinergic receptor P2X, ligand-gated ion channel, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -

Relevant External Links for P2RX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RX3 Gene

mRNA expression in normal human tissues for P2RX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RX3 Gene

This gene is overexpressed in Testis (27.7) and Heart - Left Ventricle (13.0).

Protein differential expression in normal tissues for P2RX3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for P2RX3 Gene

SOURCE GeneReport for Unigene cluster for P2RX3 Gene Hs.146738

genes like me logo Genes that share expressions with P2RX3: view

Expression partners for P2RX3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for P2RX3 Gene

Orthologs for P2RX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia P2RX3 35
  • 87.99 (n)
  • 91.44 (a)
P2RX3 36
  • 90 (a)
(Canis familiaris)
Mammalia P2RX3 35
  • 90.26 (n)
  • 94.71 (a)
P2X3 36
  • 95 (a)
(Mus musculus)
Mammalia P2rx3 35
  • 89 (n)
  • 93.7 (a)
P2rx3 16
P2rx3 36
  • 94 (a)
(Pan troglodytes)
Mammalia P2RX3 35
  • 99.58 (n)
  • 99.75 (a)
P2RX3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia P2rx3 35
  • 88.33 (n)
  • 93.95 (a)
(Monodelphis domestica)
Mammalia P2RX3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia P2RX3 36
  • 80 (a)
(Gallus gallus)
Aves LOC423134 35
  • 71.57 (n)
  • 71.07 (a)
P2RX3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia P2RX3 36
  • 76 (a)
(Danio rerio)
Actinopterygii p2rx3b 35
  • 66.58 (n)
  • 69.47 (a)
p2rx3b 36
  • 66 (a)
Species with no ortholog for P2RX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX3 Gene

Gene Tree for P2RX3 (if available)
Gene Tree for P2RX3 (if available)

Paralogs for P2RX3 Gene

Paralogs for P2RX3 Gene

(6) SIMAP similar genes for P2RX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with P2RX3: view

Variants for P2RX3 Gene

Sequence variations from dbSNP and Humsavar for P2RX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs879646 -- 57,356,722(+) ATATG(C/T)GTTAA intron-variant
rs894450 -- 57,365,897(+) GTTGT(A/G)CAGGT intron-variant
rs1815768 -- 57,348,269(-) TGGAG(C/G)CTTAC intron-variant
rs1815769 -- 57,364,985(-) CAGGG(C/G)AGCCT intron-variant
rs1837974 -- 57,355,471(-) CCCAG(C/G)TACTG intron-variant

Relevant External Links for P2RX3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RX3 Gene

Disorders for P2RX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for P2RX3 Gene in MalaCards »

(1) Disease for P2RX3 Gene

(2) University of Copenhagen DISEASES for P2RX3 Gene

(3) Novoseek inferred disease relationships for P2RX3 Gene

Disease -log(P) Hits PubMed IDs
overactive bladder 52.7 2
hyperalgesia 48.4 1
inflammation 0 1
genes like me logo Genes that share disorders with P2RX3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for P2RX3 Gene

Publications for P2RX3 Gene

  1. Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. (PMID: 12885270) Jarvis M.F. (Expert Opin. Ther. Targets 2003) 3 23
  2. Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. (PMID: 14520770) Renton T. … Anand P. (J Orofac Pain 2003) 3 23
  3. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M. … Stuhmer W. (Mol. Pharmacol. 1997) 3 4
  4. Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. (PMID: 9221902) Garcia-Guzman M. … Soto F. (Brain Res. Mol. Brain Res. 1997) 2 3
  5. Expression of P2X3 purinoceptors in suburothelial myofibroblasts of the normal human urinary bladder. (PMID: 19456993) Liu F. … Yamaguchi O. (Int. J. Urol. 2009) 3 23

Products for P2RX3 Gene

Sources for P2RX3 Gene

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