Aliases for P2RX3 Gene
External Ids for P2RX3 Gene
Previous GeneCards Identifiers for P2RX3 Gene
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]
GeneCards Summary for P2RX3 Gene
P2RX3 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 3) is a Protein Coding gene. Diseases associated with P2RX3 include burning mouth syndrome. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include purinergic nucleotide receptor activity and extracellular ATP-gated cation channel activity. An important paralog of this gene is P2RX1.
UniProtKB/Swiss-Prot for P2RX3 Gene
Receptor for ATP that acts as a ligand-gated ion channel
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility and nociception.