Free for academic non-profit institutions. Other users need a Commercial license

OXTR Gene(Protein Coding)

Oxytocin Receptor

GCID:
GC03M008767
GIFtS:
57
Genes Participants
UDN Logo

Aliases for OXTR Gene

Aliases for OXTR Gene

  • Oxytocin Receptor 2 3 5
  • OT-R 3 4

External Ids for OXTR Gene

Previous GeneCards Identifiers for OXTR Gene

  • GC03M008721

Summaries for OXTR Gene

Entrez Gene Summary for OXTR Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

GeneCards Summary for OXTR Gene

OXTR (Oxytocin Receptor) is a Protein Coding gene. Diseases associated with OXTR include Prosopagnosia and Alexithymia. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for OXTR Gene

  • Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for OXTR Gene

  • Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland.

Gene Wiki entry for OXTR Gene

Additional gene information for OXTR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXTR Gene

Genomics for OXTR Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OXTR Gene

Promoters and enhancers for OXTR Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I008768 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558.2 +85.2 85188 2.1 RB1 ARID4B SIN3A BATF ZNF2 ZBTB7B ZNF48 RAD21 RFX5 ZNF335 OXTR SSUH2 CAV3
GH03I008855 Enhancer 0.2 ENCODE 564.3 -1.9 -1929 1.9 OXTR GC03P008932 RAD18
GH03I008961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.8 -109.9 -109892 5.1 SMAD1 FOXA2 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 RAD18 BRPF1 ENSG00000199815 SETD5 OXTR SRGAP3-AS1
GH03I008739 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10 +113.2 113190 3.6 FOXA2 ARID4B ZNF2 GLIS2 E2F8 FOS SP3 SP5 REST SMARCA4 SETD5 RAD18 THUMPD3-AS1 OXTR CAV3 SSUH2
GH03I008868 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.8 -15.3 -15294 2.8 JUN SIN3A ZKSCAN1 TEAD3 FOSL1 CTBP1 GATA3 POLR2A FOSL2 FOS OXTR ENSG00000199815 RAD18 GC03P008932
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OXTR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OXTR gene promoter:

Genomic Locations for OXTR Gene

Genomic Locations for OXTR Gene
chr3:8,750,408-8,854,549
(GRCh38/hg38)
Size:
104,142 bases
Orientation:
Minus strand
chr3:8,792,094-8,811,314
(GRCh37/hg19)

Genomic View for OXTR Gene

Genes around OXTR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXTR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXTR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OXTR Gene

Proteins for OXTR Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OXTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30559-OXYR_HUMAN
    Recommended name:
    Oxytocin receptor
    Protein Accession:
    P30559
    Secondary Accessions:
    • Q15071

    Protein attributes for OXTR Gene

    Size:
    389 amino acids
    Molecular mass:
    42772 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXTR Gene

Protein Expression for OXTR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OXTR Gene

  • Glycosylation at isoforms=8, Asn15, and isoforms=26

Other Protein References for OXTR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OXTR Gene

Domains & Families for OXTR Gene

Gene Families for OXTR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for OXTR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OXTR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30559

UniProtKB/Swiss-Prot:

OXYR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with OXTR: view

Function for OXTR Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OXTR Gene

GENATLAS Biochemistry:
oxytocin receptor ,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for OXTR Gene

Gene Ontology (GO) - Molecular Function for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004990 oxytocin receptor activity IBA,IEA --
GO:0005000 vasopressin receptor activity IBA,IEA --
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with OXTR: view
genes like me logo Genes that share phenotypes with OXTR: view

Animal Models for OXTR Gene

MGI Knock Outs for OXTR:

Animal Model Products

Clone Products

  • Addgene plasmids for OXTR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OXTR Gene

Localization for OXTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXTR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXTR gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10858434
GO:0005902 microvillus IEA --
GO:0005913 cell-cell adherens junction IEA --
genes like me logo Genes that share ontologies with OXTR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OXTR Gene

Pathways & Interactions for OXTR Gene

genes like me logo Genes that share pathways with OXTR: view

SIGNOR curated interactions for OXTR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0001975 response to amphetamine IEA --
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA --
GO:0006936 muscle contraction TAS 1313946
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with OXTR: view

Drugs & Compounds for OXTR Gene

Products:

  1. Drug

(84) Drugs for OXTR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxytocin Approved, Vet_approved Pharma Full agonist, Agonist, Target, agonist Involved in uterine contraction and lactation 474
Carbetocin Approved, Investigational Pharma Target, agonist Oxytocin analog 37
Vasopressin Approved Pharma Full agonist, Agonist, agonist 0
Desmopressin Approved Pharma Full agonist, Agonist, stimulator Hemostatic and anti-diuretic 0
calcium Approved Nutra 0

(29) Additional Compounds for OXTR Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]AVP
Full agonist, Agonist
AVT
Full agonist, Agonist

(5) Tocris Compounds for OXTR Gene

Compound Action Cas Number
Carbetocin Oxytocin analog 37025-55-1
L-371,257 Potent and selective oxytocin receptor antagonist 162042-44-6
Oxytocin Involved in uterine contraction and lactation 50-56-6
TC OT 39 Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist 479232-57-0
WAY 267464 dihydrochloride Potent non-peptide oxytocin receptor agonist 1432043-31-6

(9) ApexBio Compounds for OXTR Gene

Compound Action Cas Number
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin 73168-24-8
Atosiban mixed antagonist of oxytocin and vasopressin receptors 90779-69-4
d[Cha4]-AVP
d[Leu4,Lys8]-VP 42061-33-6
L-368,899 hydrochloride 160312-62-9
L-371,257 162042-44-6
PF-3274167 Oral oxytocin antagonist 900510-03-4
TC OT 39 479232-57-0
WAY 267464 dihydrochloride 1432043-31-6
genes like me logo Genes that share compounds with OXTR: view

Drug Products

Transcripts for OXTR Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OXTR Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXTR Gene

Oxytocin receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for OXTR

Alternative Splicing Database (ASD) splice patterns (SP) for OXTR Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for OXTR Gene

GeneLoc Exon Structure for
OXTR
ECgene alternative splicing isoforms for
OXTR

Expression for OXTR Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OXTR Gene

mRNA expression in normal human tissues for OXTR Gene
mRNA expression by GTEx for OXTR GenemRNA expression by BioGPS for OXTR Gene

mRNA differential expression in normal tissues according to GTEx for OXTR Gene

This gene is overexpressed in Breast - Mammary Tissue (x11.5).

Protein differential expression in normal tissues from HIPED for OXTR Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.3) and Platelet (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXTR Gene



Protein tissue co-expression partners for OXTR Gene

NURSA nuclear receptor signaling pathways regulating expression of OXTR Gene:

OXTR

SOURCE GeneReport for Unigene cluster for OXTR Gene:

Hs.2820

Evidence on tissue expression from TISSUES for OXTR Gene

  • Nervous system(3)
  • Muscle(2.3)
  • Skin(2.3)
  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with OXTR: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OXTR Gene

Orthologs for OXTR Gene

This gene was present in the common ancestor of animals.

Orthologs for OXTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OXTR 33 34
  • 99.23 (n)
dog
(Canis familiaris)
 Mammalia OXTR 33 34
  • 90.94 (n)
cow
(Bos Taurus)
 Mammalia OXTR 33 34
  • 88.32 (n)
rat
(Rattus norvegicus)
 Mammalia Oxtr 33
  • 87.37 (n)
mouse
(Mus musculus)
 Mammalia Oxtr 33 16 34
  • 87.01 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia OXTR 34
  • 79 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia OXTR 34
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves OXTR 33 34
  • 77.91 (n)
lizard
(Anolis carolinensis)
 Reptilia OXTR 34
  • 70 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493876 33
  • 70.22 (n)
zebrafish
(Danio rerio)
 Actinopterygii oxtrl 33 34
  • 68.1 (n)
oxtr 34
  • 63 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta GRHR 35
  • 31 (a)
CG6111 35
  • 29 (a)
Species where no ortholog for OXTR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXTR Gene

ENSEMBL:
Gene Tree for OXTR (if available)
TreeFam:
Gene Tree for OXTR (if available)

Paralogs for OXTR Gene

Paralogs for OXTR Gene

(5) SIMAP similar genes for OXTR Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OXTR: view

Variants for OXTR Gene

Sequence variations from dbSNP and Humsavar for OXTR Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000018443 -- 8,761,794(-) G/A intron_variant
rs1000136584 -- 8,767,555(-) C/A coding_sequence_variant, synonymous_variant
rs1000584092 -- 8,757,698(-) A/G intron_variant
rs1000858546 -- 8,766,317(-) C/A intron_variant
rs1000934937 -- 8,758,016(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OXTR Gene

Variant ID Type Subtype PubMed ID
nsv1011096 CNV loss 25217958
nsv516057 CNV loss 19592680
nsv589619 CNV loss 21841781
nsv819115 CNV gain 19587683

Variation tolerance for OXTR Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.51; 82.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OXTR Gene

Human Gene Mutation Database (HGMD)
OXTR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXTR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXTR Gene

Disorders for OXTR Gene

MalaCards: The human disease database

(18) MalaCards diseases for OXTR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prosopagnosia
alexithymia
postpartum depression
  • maternity blues
conduct disorder
asperger syndrome
  • asperger disorder
- elite association - COSMIC cancer census association via MalaCards
Search OXTR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OXTR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OXTR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OXTR Gene

Publications for OXTR Gene

  1. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. (PMID: 20094064) Liu X … Sasaki T (Journal of human genetics 2010) 3 22 44 58
  2. Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. (PMID: 20303388) Tansey KE … Anney RJ (Neuroscience letters 2010) 3 22 44 58
  3. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. (PMID: 19461999) Israel S … Ebstein RP (PloS one 2009) 3 22 44 58
  4. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (PMID: 17893705) Lerer E … Ebstein RP (Molecular psychiatry 2008) 3 22 44 58
  5. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. (PMID: 19015103) Bakermans-Kranenburg MJ … van Ijzendoorn MH (Social cognitive and affective neuroscience 2008) 3 22 44 58

Products for OXTR Gene

  • Addgene plasmids for OXTR

Sources for OXTR Gene

Content
Loading form....