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Aliases for ORC2 Gene

Aliases for ORC2 Gene

  • Origin Recognition Complex, Subunit 2 2 3
  • ORC2L 3 4 6
  • Origin Recognition Complex, Subunit 2 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 2 Homolog (Yeast) 2
  • Origin Recognition Complex, Subunit 2-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 2 Homolog 3
  • Origin Recognition Complex Protein 2 Homolog 3
  • Origin Recognition Complex Subunit 2 3

External Ids for ORC2 Gene

Previous Symbols for ORC2 Gene

  • ORC2L

Summaries for ORC2 Gene

Entrez Gene Summary for ORC2 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC2 Gene

ORC2 (Origin Recognition Complex, Subunit 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC2 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Gene Wiki entry for ORC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC2 Gene

Genomics for ORC2 Gene

Genomic Location for ORC2 Gene

Start:
200,908,973 bp from pter
End:
200,963,701 bp from pter
Size:
54,729 bases
Orientation:
Minus strand

Genomic View for ORC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC2 Gene

No data available for Regulatory Elements for ORC2 Gene

Proteins for ORC2 Gene

  • Protein details for ORC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13416-ORC2_HUMAN
    Recommended name:
    Origin recognition complex subunit 2
    Protein Accession:
    Q13416
    Secondary Accessions:
    • Q13204
    • Q53TX5

    Protein attributes for ORC2 Gene

    Size:
    577 amino acids
    Molecular mass:
    65972 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with MCM10 (PubMed:11095689). Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein (PubMed:22645314). Interacts with POLQ (PubMed:24989122).

neXtProt entry for ORC2 Gene

Proteomics data for ORC2 Gene at MOPED

Post-translational modifications for ORC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ORC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ORC2 Gene

Domains for ORC2 Gene

Protein Domains for ORC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ORC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13416

UniProtKB/Swiss-Prot:

ORC2_HUMAN
Family:
  • Belongs to the ORC2 family.:
    • Q13416
genes like me logo Genes that share domains with ORC2: view

No data available for Gene Families for ORC2 Gene

Function for ORC2 Gene

Molecular function for ORC2 Gene

UniProtKB/Swiss-Prot Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Gene Ontology (GO) - Molecular Function for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IEA --
GO:0005515 protein binding IPI 11095689
genes like me logo Genes that share ontologies with ORC2: view
genes like me logo Genes that share phenotypes with ORC2: view

miRNA for ORC2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORC2 Gene

Localization for ORC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC2 Gene

Gene Ontology (GO) - Cellular Components for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin --
GO:0000792 heterochromatin IDA 15215892
GO:0000808 origin recognition complex IDA 17716973
GO:0000939 condensed chromosome inner kinetochore IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ORC2: view

No data available for Subcellular locations from COMPARTMENTS for ORC2 Gene

Pathways for ORC2 Gene

genes like me logo Genes that share pathways with ORC2: view

Pathways by source for ORC2 Gene

1 GeneGo (Thomson Reuters) pathway for ORC2 Gene
1 Qiagen pathway for ORC2 Gene
1 Cell Signaling Technology pathway for ORC2 Gene

Gene Ontology (GO) - Biological Process for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8808289
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation TAS 8808289
genes like me logo Genes that share ontologies with ORC2: view

Compounds for ORC2 Gene

(1) Novoseek inferred chemical compound relationships for ORC2 Gene

Compound -log(P) Hits PubMed IDs
lysine 18.5 1
genes like me logo Genes that share compounds with ORC2: view

Transcripts for ORC2 Gene

Unigene Clusters for ORC2 Gene

Origin recognition complex, subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - -
SP2:
SP3: - -
SP4:

Relevant External Links for ORC2 Gene

GeneLoc Exon Structure for
ORC2
ECgene alternative splicing isoforms for
ORC2

Expression for ORC2 Gene

mRNA expression in normal human tissues for ORC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC2 Gene

SOURCE GeneReport for Unigene cluster for ORC2 Gene Hs.444870

genes like me logo Genes that share expressions with ORC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ORC2 Gene

Orthologs for ORC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC2 35
  • 99.54 (n)
  • 99.13 (a)
ORC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORC2 35
  • 91.15 (n)
  • 89.91 (a)
ORC2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORC2 35
  • 91.9 (n)
  • 91.84 (a)
ORC2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc2 35
  • 84.55 (n)
  • 78.99 (a)
Orc2 16
Orc2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ORC2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Orc2 35
  • 84.03 (n)
  • 79.09 (a)
chicken
(Gallus gallus)
Aves ORC2 35
  • 68.84 (n)
  • 67.78 (a)
ORC2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC2 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia orc2-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia orc2 35
  • 64.53 (n)
  • 63.62 (a)
Str.20373 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12649 35
ORC2 36
  • 61 (a)
OneToOne
zgc:153041 35
  • 59.8 (n)
  • 58.64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000474 35
  • 45.49 (n)
  • 40.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Orc2 35
  • 47 (n)
  • 41.19 (a)
Orc2 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea orc-2 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC2 36
  • 19 (a)
OneToOne
ORC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC2 35
  • 47.03 (n)
  • 37.9 (a)
rice
(Oryza sativa)
Liliopsida Os03g0184700 35
  • 47.94 (n)
  • 38.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for ORC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORC2 Gene

ENSEMBL:
Gene Tree for ORC2 (if available)
TreeFam:
Gene Tree for ORC2 (if available)

Paralogs for ORC2 Gene

No data available for Paralogs for ORC2 Gene

Variants for ORC2 Gene

Sequence variations from dbSNP and Humsavar for ORC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11048 -- 200,910,242(-) TACCC(C/T)CTGAA utr-variant-3-prime, nc-transcript-variant
rs714362 -- 200,965,455(-) GTCTC(A/G)ATGTG upstream-variant-2KB
rs874358 -- 200,964,879(-) CAGGG(C/G)TTTCA upstream-variant-2KB
rs1182843 -- 200,929,000(-) ctggg(C/T)gacag intron-variant
rs1184514 -- 200,916,265(-) cctca(A/T)gtgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORC2 Gene

Variant ID Type Subtype PubMed ID
nsv3109 CNV Loss 18451855

Relevant External Links for ORC2 Gene

HapMap Linkage Disequilibrium report
ORC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC2 Gene

Disorders for ORC2 Gene

(1) Novoseek inferred disease relationships for ORC2 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1
genes like me logo Genes that share disorders with ORC2: view

No data available for UniProtKB/Swiss-Prot for ORC2 Gene

Publications for ORC2 Gene

  1. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. (PMID: 8808289) Takahara K. … Greenspan D.S. (Genomics 1996) 2 3 4 23
  2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PMID: 11095689) Izumi M. … Hanaoka F. (Nucleic Acids Res. 2000) 3 4 23
  3. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. (PMID: 11509178) Dhar S.K. … Dutta A. (Cell 2001) 3 23
  4. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. (PMID: 11602595) Izumi M. … Hanaoka F. (J. Biol. Chem. 2001) 3 23
  5. Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. (PMID: 9733749) Ritzi M. … Knippers R. (J. Biol. Chem. 1998) 3 23

Products for ORC2 Gene

Sources for ORC2 Gene

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