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OR3A1 Gene(Protein Coding)

Olfactory Receptor Family 3 Subfamily A Member 1

GCID:
GC17M003292
GIFtS:
47
Genes Participants
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Aliases for OR3A1 Gene

Aliases for OR3A1 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 1 2 3 5
  • Olfactory Receptor, Family 3, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR17-15 3 4
  • Olfactory Receptor 17-40 3 4
  • OLFRA03 3 4
  • OR17-40 3 4
  • OR17-82 3
  • OR40 3

External Ids for OR3A1 Gene

Previous GeneCards Identifiers for OR3A1 Gene

  • GC17M003509
  • GC17M003536
  • GC17M003145
  • GC17M003401
  • GC17M003141
  • GC17M003194

Summaries for OR3A1 Gene

Entrez Gene Summary for OR3A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A1 Gene

OR3A1 (Olfactory Receptor Family 3 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A2.

UniProtKB/Swiss-Prot for OR3A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A1 Gene

Genomics for OR3A1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for OR3A1 Gene

Enhancers for OR3A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR3A1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OR3A1 gene promoter:

Genomic Location for OR3A1 Gene

Chromosome:
17
Start:
3,288,318 bp from pter
End:
3,386,209 bp from pter
Size:
97,892 bases
Orientation:
Minus strand

Genomic View for OR3A1 Gene

Genes around OR3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR3A1 Gene

Proteins for OR3A1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47881-OR3A1_HUMAN
    Recommended name:
    Olfactory receptor 3A1
    Protein Accession:
    P47881
    Secondary Accessions:
    • Q4VB06
    • Q6IFM4

    Protein attributes for OR3A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A1 Gene

Proteomics data for OR3A1 Gene at MOPED

Post-translational modifications for OR3A1 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A1 Gene

Domains & Families for OR3A1 Gene

Gene Families for OR3A1 Gene

HGNC:

Protein Domains for OR3A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OR3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47881

UniProtKB/Swiss-Prot:

OR3A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A1: view

Function for OR3A1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for OR3A1 Gene

GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 1,G protein coupled receptor superfamily,with odorant ligand
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR3A1 Gene

GenomeRNAi human phenotypes for OR3A1:
genes like me logo Genes that share phenotypes with OR3A1: view

Animal Model Products

CRISPR Products

miRNA for OR3A1 Gene

miRTarBase miRNAs that target OR3A1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A1 Gene

Localization for OR3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR3A1 Gene COMPARTMENTS Subcellular localization image for OR3A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR3A1: view

Pathways & Interactions for OR3A1 Gene

genes like me logo Genes that share pathways with OR3A1: view

Pathways by source for OR3A1 Gene

2 BioSystems pathways for OR3A1 Gene
1 KEGG pathway for OR3A1 Gene

Gene Ontology (GO) - Biological Process for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA,TAS 8647456
genes like me logo Genes that share ontologies with OR3A1: view

No data available for SIGNOR curated interactions for OR3A1 Gene

Drugs & Compounds for OR3A1 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR3A1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for OR3A1 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A1 Gene

No ASD Table

Relevant External Links for OR3A1 Gene

GeneLoc Exon Structure for
OR3A1
ECgene alternative splicing isoforms for
OR3A1

Expression for OR3A1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for OR3A1 Gene

mRNA expression in normal human tissues for OR3A1 Gene
mRNA expression by BioGPS for OR3A1 GenemRNA expression by GTEx for OR3A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A1 Gene

This gene is overexpressed in Testis (x14.3).

SOURCE GeneReport for Unigene cluster for OR3A1 Gene Hs.647410

genes like me logo Genes that share expression patterns with OR3A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR3A1 Gene

Orthologs for OR3A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia OR3A1 35
  • 89.07 (n)
  • 86.94 (a)
OR3A1 36
  • 84 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC491212 35
  • 87.62 (n)
  • 86.35 (a)
OR3A1 36
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Olfr402 35
  • 83.28 (n)
  • 82.86 (a)
Olfr402 16
Olfr401 36
  • 81 (a)
 OneToMany
Olfr402 36
  • 83 (a)
 OneToMany
Olfr410 36
  • 85 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia LOC468152 35
  • 98.52 (n)
  • 97.78 (a)
OR3A1 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Olr1517 35
  • 84.87 (n)
  • 84.76 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 66 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 46 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 36
  • 37 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 39 (a)
 ManyToMany
Species with no ortholog for OR3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A1 Gene

ENSEMBL:
Gene Tree for OR3A1 (if available)
TreeFam:
Gene Tree for OR3A1 (if available)

Paralogs for OR3A1 Gene

Paralogs for OR3A1 Gene

(456) SIMAP similar genes for OR3A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR3A1: view

Variants for OR3A1 Gene

Sequence variations from dbSNP and Humsavar for OR3A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs703903 - 3,292,209(+) GGAAT(A/C/T)GGTCA reference, missense
rs16952828 - 3,292,351(+) GACGC(C/T)GATGC reference, missense
rs151131 -- 3,347,525(+) ttact(A/G)agaat intron-variant
rs151132 -- 3,368,654(+) agtta(G/T)aagtt intron-variant
rs151133 -- 3,371,031(+) agaca(C/T)ggcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR3A1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv907553 CNV Loss 21882294
nsv907555 CNV Loss 21882294
nsv907557 CNV Loss 21882294
dgv3041n71 CNV Gain 21882294
nsv457638 CNV Gain 19166990
nsv470570 CNV Gain 18288195
nsv457639 CNV Gain 19166990
nsv827859 CNV Gain 20364138
nsv907560 CNV Gain 21882294
nsv907561 CNV Gain 21882294
nsv907562 CNV Gain 21882294

Variation tolerance for OR3A1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR3A1 Gene

Disorders for OR3A1 Gene

Relevant External Links for OR3A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR3A1

No disorders were found for OR3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A1 Gene

Publications for OR3A1 Gene

  1. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G. … Lancet D. (Genomics 1996) 2 3 4 67
  2. Olfactory receptor-encoding genes and pseudogenes are expressed in humans. (PMID: 8647456) Crowe M.L. … Connerton I.F. (Gene 1996) 2 3
  3. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (PMID: 23958962) Gelernter J. … Farrer L. (Mol. Psychiatry 2013) 3
  4. Stimulation of human olfactory receptor 17-40 with odorants probed by surface plasmon resonance. (PMID: 18247023) Benilova I. … Jaffrezic-Renault N. (Eur. Biophys. J. 2008) 23
  5. A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40. (PMID: 17579849) Marrakchi M. … Pajot-Augy E. (Eur. Biophys. J. 2007) 3

Products for OR3A1 Gene

Sources for OR3A1 Gene

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