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Aliases for OR1F1 Gene

Aliases for OR1F1 Gene

  • Olfactory Receptor Family 1 Subfamily F Member 1 2 3 5
  • OR1F10 3 4
  • OR1F4 3 4
  • OR1F5 3 4
  • OR1F6 3 4
  • OR1F7 3 4
  • OR1F8 3 4
  • OR1F9 3 4
  • OLFMF 3 4
  • Olfactory Receptor, Family 1, Subfamily F, Member 13 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 10 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 6 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 7 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 9 3
  • Olfactory Receptor OR16-4 4
  • Olfactory Receptor 16-35 4
  • Olfactory Receptor 1F10 4
  • Olfactory Receptor 1F1 3
  • Olfactory Receptor 1F4 4
  • Olfactory Receptor 1F5 4
  • Olfactory Receptor 1F6 4
  • Olfactory Receptor 1F7 4
  • Olfactory Receptor 1F8 4
  • Olfactory Receptor 1F9 4
  • OR16-36 3
  • OR16-37 3
  • OR16-88 3
  • OR16-89 3
  • OR16-90 3
  • OR3-145 3
  • ORL1023 3
  • OR1F13P 3
  • OR16-35 4

External Ids for OR1F1 Gene

Previous HGNC Symbols for OR1F1 Gene

  • OR1F4
  • OR1F6
  • OR1F7
  • OR1F8
  • OR1F9
  • OR1F5
  • OR1F10
  • OR1F13P

Previous GeneCards Identifiers for OR1F1 Gene

  • GC16P003274
  • GC16P003255
  • GC16P003256
  • GC16P003195
  • GC16P003257
  • GC16P003260
  • GC16P003269
  • GC16P003218
  • GC16P003249
  • GC16P003288
  • GC16P003326
  • GC16P003352

Summaries for OR1F1 Gene

Entrez Gene Summary for OR1F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1F1 Gene

OR1F1 (Olfactory Receptor Family 1 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1C1.

UniProtKB/Swiss-Prot for OR1F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1F1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1F1 Gene

Genomics for OR1F1 Gene

Regulatory Elements for OR1F1 Gene

Enhancers for OR1F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003105 1.8 FANTOM5 ENCODE dbSUPER 2.4 -84.7 -84729 2.2 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF205 ZNF213-AS1 CLUAP1 TIGD7 MTCO1P28 ZNF174 MTRNR2L4 MTND1P8 SNHG19 ENSG00000260447
GH16G003296 0.5 FANTOM5 7 +104.4 104443 0.2 ZNF366 POLR2A RBFOX2 OR2C1 ZNF263 ZNF200 MEFV ZNF174 ZSCAN32 C16orf90 OR1F1 SLX4 CLUAP1
GH16G003097 2 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -91.0 -90995 6.2 CREB3L1 MLX ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 ZNF263 SNHG19 SNORD60 ZNF213-AS1 THOC6 ZNF597 ERVK13-1 LOC105371055 CREBBP
GH16G003462 0.3 FANTOM5 9.3 +271.1 271128 0.3 OR1F1 OR2C1 CLUAP1 TIGD7 ENSG00000263212 GC16M003477
GH16G002795 1.5 FANTOM5 Ensembl ENCODE 1.1 -395.0 -395012 1.5 PKNOX1 KLF7 FOS ZNF518A SMARCA4 GLIS1 WT1 KLF1 ZBTB21 FOSL1 MEFV PDPK1 SRRM2 ATP6V0C ZNF200 OR1F1 ENSG00000221719 GC16M002796 PRSS33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1F1 on UCSC Golden Path with GeneCards custom track

Promoters for OR1F1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279477 -1495 401 ARNT ARID4B SIN3A FEZF1 ZNF2 FOS KLF13 ZNF263 SP3 ZHX2

Genomic Location for OR1F1 Gene

3,191,095 bp from pter
3,205,344 bp from pter
14,250 bases
Plus strand

Genomic View for OR1F1 Gene

Genes around OR1F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1F1 Gene

Proteins for OR1F1 Gene

  • Protein details for OR1F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1F1
    Protein Accession:
    Secondary Accessions:
    • O15246
    • Q6IFL5

    Protein attributes for OR1F1 Gene

    312 amino acids
    Molecular mass:
    34866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1F1 Gene

Post-translational modifications for OR1F1 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1F1 Gene

Domains & Families for OR1F1 Gene

Gene Families for OR1F1 Gene

Protein Domains for OR1F1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1F1: view

Function for OR1F1 Gene

Molecular function for OR1F1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1F1: view
genes like me logo Genes that share phenotypes with OR1F1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1F1 Gene

Localization for OR1F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1F1: view

Pathways & Interactions for OR1F1 Gene

genes like me logo Genes that share pathways with OR1F1: view

Pathways by source for OR1F1 Gene

1 KEGG pathway for OR1F1 Gene

Interacting Proteins for OR1F1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: O43749-OR1F1_HUMAN ENSP00000305424 for OR1F1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9500546
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1F1: view

No data available for SIGNOR curated interactions for OR1F1 Gene

Drugs & Compounds for OR1F1 Gene

No Compound Related Data Available

Transcripts for OR1F1 Gene

mRNA/cDNA for OR1F1 Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1F1 Gene

No ASD Table

Relevant External Links for OR1F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1F1 Gene

This gene is overexpressed in Brain - Cerebellum (x11.8) and Brain - Cerebellar Hemisphere (x10.1).

NURSA nuclear receptor signaling pathways regulating expression of OR1F1 Gene:


SOURCE GeneReport for Unigene cluster for OR1F1 Gene:

genes like me logo Genes that share expression patterns with OR1F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1F1 Gene

Orthologs for OR1F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC539468 34
  • 86.34 (n)
-- 35
  • 83 (a)
-- 35
  • 82 (a)
-- 35
  • 79 (a)
(Rattus norvegicus)
Mammalia Olr1378 34
  • 82.64 (n)
(Mus musculus)
Mammalia Or1f19 55 Olfr161 35
  • 73 (a)
Or1ad1 55 Olfr1377
  • chr11:50,984,703-50,985,623
Or1ad5-ps 55 Olfr1376-ps1
  • chr11:50,991,792-50,992,740
Or1ad6 55 Olfr1378
  • chr11:50,969,020-50,969,964
Or1f20-ps 55 Olfr162-ps1
  • chr16:3,601,922-3,602,862
Or1f21-ps 55 Olfr163-ps1
  • chr16:3,618,089-3,618,869
(Monodelphis domestica)
Mammalia OR1F1 35
  • 71 (a)
(Canis familiaris)
Mammalia OR10A11 35
  • 61 (a)
Species where no ortholog for OR1F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1F1 Gene

Gene Tree for OR1F1 (if available)
Gene Tree for OR1F1 (if available)

Paralogs for OR1F1 Gene

(455) SIMAP similar genes for OR1F1 Gene using alignment to 1 proteins: Pseudogenes for OR1F1 Gene

genes like me logo Genes that share paralogs with OR1F1: view

Variants for OR1F1 Gene

Sequence variations from dbSNP and Humsavar for OR1F1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000145116 -- 3,205,541(+) GTTGC(A/G)GGAAG downstream-variant-500B, utr-variant-3-prime
rs1000168001 -- 3,190,396(+) TTGGG(A/G)CGCTG intron-variant, upstream-variant-2KB
rs1000181587 -- 3,194,247(+) GTGGG(A/G)AAATG intron-variant
rs1000184328 -- 3,190,716(+) AGTGC(A/G)CTCCA intron-variant, upstream-variant-2KB
rs1000296663 -- 3,187,072(+) TGTTG(A/G)CCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1F1 Gene

Variant ID Type Subtype PubMed ID
esv3581941 CNV loss 25503493
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1713 CNV insertion 18451855
nsv457355 CNV gain 19166990
nsv471074 CNV gain 18288195
nsv524873 CNV loss 19592680
nsv571249 CNV gain 21841781
nsv833127 CNV gain+loss 17160897

Variation tolerance for OR1F1 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.99; 92.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1F1 Gene

Disorders for OR1F1 Gene

Relevant External Links for OR1F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1F1 Gene

Publications for OR1F1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4 64
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) Bernot A. … Grateau G. (Nat. Genet. 1997) 2 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR1F1 Gene

Sources for OR1F1 Gene

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